Cognitive Neuroscience Presentation
Transcript: Thank You! High activation of DLS in fMRI studies in humans References Muskens et al., 2012 Future Studies & Improvements Diamler Vadlamuri We Know Ethanol disrupts cognitive processes of the Prefrontal Cortex (DePoy et al., 2013). Higher activations of the dorsal striatum in heavy drinkers compared to light drinkers via fMRI studies Long lasting change in DLS? DLS could be responsible for addictive behavior Chronic Intermittent ethanol increases DLS dendritic hypertrophy & synaptic plasticity Higher activations of the dorsal striatum in heavy drinkers compared to light drinkers via fMRI studies Dorsal Striatum (DLS): Regulates initiation & timing of movements Skilled motor behaviors Chronic Alcoholism causes DLS dendritic hypertrophy and altered DLS synaptic plasticity Chronic Alcohol Exposure Increases DLS Neuronal Activity observed through Neuronal dendritic expansion in rodents and higher activation of DLS in humans via fMRI studies. DePoy, L., Daut, R., Brigman, J. L., MacPherson, K., Crowley, N., Gunduz-Cinar, O., & Holmes, A. (2013). Chronic alcohol produces neuroadaptations to prime dorsal striatal learning. Proceedings of the National Academy of Sciences, 110(36), 14783-14788. Chicago Fanelli, R. R., Klein, J. T., Reese, R. M., & Robinson, D. L. (2013). Dorsomedial and dorsolateral striatum exhibit distinct phasic neuronal activity during alcohol self‐administration in rats. European Journal of Neuroscience,38(4), 2637-2648. Fanelli, R. R., & Robinson, D. L. (2014). Dopamine D1 receptor blockade impairs alcohol seeking without reducing dorsal striatal activation to cues of alcohol availability. Brain and Behavior. Muskens, J. B., Schellekens, A. F. A., de Leeuw, F. E., Tendolkar, I., & Hepark, S. (2012). Damage in the dorsal striatum alleviates addictive behavior. General hospital psychiatry, 34(6), 702-e9. Chicago Vollstädt-Klein, S., Wichert, S., Rabinstein, J., Bühler, M., Klein, O., Ende, G., ... & Mann, K. (2010). Initial, habitual and compulsive alcohol use is characterized by a shift of cue processing from ventral to dorsal striatum. Addiction, 105(10), 1741-1749. Zorumski, C. F., Mennerick, S., & Izumi, Y. (2014). Acute and chronic effects of ethanol on learning-related synaptic plasticity. Alcohol, Thesis DePoy et al., 2013 Effects of Chronic Alcoholism on the Dorsal Striatum (DLS) Vollstädt-Klein et al., 2010 Goals: Connection between DLS and addictive behavior Parallel changes in PFC and DLS with CIE? Magnetic resonance imaging (MRI) of the ischemic lesion in the caudate–putamen complex Summary Larger sample size, stronger link towards addiction CIE causes DLS dendritic hypertrophy and altered DLS synaptic plasticity Why do we care?