Sickle cell
Transcript: The only cure for sickle cell anemia is a bone marrow transplant, but these are very risky and it is difficult to find a donor. Most people only seek treatments for the symptoms and to avoid complecations. Some treatments may be Taking Folic Acid and other vitamin supplements Hydroxyurea Pain medications Blood Transfusions Antibiotics and immunizations Supplemental oxygen Bone marrow transplant Nitric oxide therapy Staying hydrated Reducing stress and avoiding extreme temperatures Planning ahead when flying or visiting high altitude areas Sickle cell anemia is a hereditary disease where red blood cells become an abnormal sickle shape as apposed to a healthy circle shape. These abnormal cells die much quicker than normal blood cells, leaving the body with anemia. (where the body doesn't have enough blood cells). It is usually detected by a blood test just after birth. Why is it harmful? The beta globin gene in the body takes the passed on mutation and causes abnormal hemoglobin (HbS) to be created. This abnormal hemoglobin clumps together inside the red blood cell to form long, inflexible strands that elongate the cell and give it the sickled shape. Cells can switch between sickle and regular shapes, but they eventually become permanently sickled. These sickled cells can't use oxygen like a normal blood cell because the abnormal HbS prevents the absorption of oxygen by the hemoglobin. The oxygen floating around can take in nearby stray electrons and become an O2 superoxide anion. These anions may then attack the membrane of the blood cell and form lesions that allow them into the cell. Once inside the cell the O2 anions can hit the HbS molecules. When the anions hit the HbS they combine and turns the HbS molecule into a meta HbS molecule that clumps with other mHbS molecules to form Heinz bodies (made of damaged hemoglobin). Heinz bodies attach to the inside of the cell membrane and cause the cell to die prematurely and be taken out from the blood by macrophages in the spleen. Because so many of these cells are taken out, the body doesn't have enough blood cells and becomes anemic. What are the symptoms? Sickle cell anemia can lead to strokes, acute chest syndrome (a lung infection or sickle cells blocking blood vessels in the lungs), pulminary hypertension, blindness, organ damage, sores, and gallstones Sickle cell anemia is caused by a mutation in the gene that makes the bodies hemoglobin. This mutated hemoglobin forms into long strands and causes the cells to become rigid and sickle-shaped. The mutation is passed down through a family and is recessive. People who carry the disease (have the gene from one parent) may create some sickle cells in their blood but not enough to interfere with the body and won't have symptoms. Having the trait and creating sickle cells does not mean you have the disease. The disease is caused by the trait. In the past, people who were a carrier of this sickle cell mutation had a greater resistance against malaria, and a greater chance of surviving to pass on their genes. Treatment Options Interesting Facts Normal bloodstream What causes the disease? Bibliography 1 in 400 African Americans has sickle cell anemia. It's not a disease, it's a trait. If both parents have this trait each offspring has a 25% chance of getting it. sickle cells live for 10 to 20 days while regular cells can live for 150 Sickle cells are most common in people from Africa, India, the Caribbean, the Middle East, and the Mediterranean Sickle cell disease is the most common inherited blood disorder What is it? Symptoms can appear when a person is as young as 4 months old and can include: Anemia (chronic shortage of red blood cells) Periodic episodes of pain Swollen hands and feet Frequent infections Delayed growth and/or delayed puberty Vision problems Pail skin & nail beds Yellow tint to the skin and eyes Strokes What is wrong with the blood cells? Sickle Cell Anemia Bloodstream with Sickle cells What does it look like? Mayo Clinic Staff, . "Sickle Cell Anemia -MayoClinic." Mayo Clinic. Mayo Foundation for Medical Education and Research , May 26, 2011. Web. 8 Mar 2012. <http://www.mayoclinic.com/health/sickle-cell-anemia/DS00324>. Miller, Robin E., MD. "Sickle Cell Anemia." Teens health. The Nemours Foundation, July 2009. Web. 8 Mar 2012. <http://kidshealth.org/teen/diseases_conditions/blood/sickle_cell_anemia.html Board, A.D.A.M. Editorial. "Causes, Incidence, and Risk Factors." Sickle Cell Anemia. U.S. National Library of Medicine, 18 Nov. 0000. Web. 08 Mar. 2012. <http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001554/>. Academiadeciencia. "Sickle Cell Disease." YouTube. YouTube, 25 Feb. 2011. Web. 08 Mar. 2012. <http://www.youtube.com/watch?v=R4-c3hUhhyc>. "Everything Majestique!: Interesting Facts about Sickle Cell Disease!" Everything Majestique! Web. 12 Mar. 2012. <http://majestiqueworld.blogspot.com/2008/07/interesting-facts-about-sickle-cell.html>.