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medicinal chemistry

Transcript: is located at: 601 S. Morgan St. Chicago, IL 60607 4-Bedroom Apartment for 4: $9,398 pharmaceutical chemistry Medical Biotechnology MS: $3,449 UIC's Campus 12 Credit Hours: $5,441 Commons North (CMN) aka: Single Room Style (3–4 Residents) : $11,536 Single Room Style (5–6 Residents) : $11,350 your Ph.D. two years of post-doctoral experience. Degree Requirements General Information: (312) 996-4350 2-Bedroom Apartment for 2: $9,572 University of Illinois at Chicago By: Jordan Nichols can also be associated with: virtual walking tour that introduces the modernist architecture Office of Admissions and Records (MC 018): University of Illinois at Chicago Box 5220 Chicago, Illinois 60680-5220 Required Core Courses: GCLS 501 •MDCH 561 •four hours of MDCH 592 •plus a minimum of 6 additional hours of required concentration and elective courses. GPA: at least 3.00 (A=4.00) for the final 60 semester (90 quarter) hours of baccalaureate study. biomedicinal chemistry To become a medicinal chemist you must recieve... 4. Assessment Single Room Style: $10,826 General Fee: $425 Service Fee: $314 Student-Student Fee: $3 Sustainability Fee: $4 Health Service Fee: $88 Estimated Health Insurance Fee: $401 Estimated CTA U Pass Fee: $109 Required Concentration Courses: •Analytical and Chemical Toxicology – MDCH 412, 562, 571 •Biomedicinal Chemistry – GCLS 502; MDCH 412 •Computational Medicinal Chemistry – MDCH 572 •Structural Biology – BCHE(PMPG) 513 •Synthetic Medicinal Chemistry – MDCH 560, 562, 571. 1. Graduate Tuition Size: about 240 acres; Tuition and Fees Room and Board: Tests Required: GRE general and have at least... Academic Facilities Maintenance Fund Assessment: $309 3. Graduate Fees College that offers this major is: Campus Attractions Medicinal Chemistry: 16,806 students enrolled Medicinal Chemistry Letters of Recommendation: Three required •Baccalaureate Field: Pharmacy, chemistry, or the biological sciences. Prior academic work should include a year each of biology or biochemistry and organic chemistry. Admission Requirements Administration/Operations: 312-996-7000 2. Graduate Tuition Differentials The Historic Netsch Campus organic chemistry TOTAL COST: $10,743 Contact us Commons South (CMS) toxicologists Library and Information Technology Assessment: $200 Thomas Beckham Hall (TBH) & Marie Robinson Hall (MRH) the application of chemical research techniques to the synthesis of pharmaceuticals to develop and create drugs for human usages Studio Apartment for 1: $11,318

Medicinal Chemistry

Transcript: Because of the economy and government health care reform regulations medicinal chemist in today's market is mixed.Theres allot of changes going on causing companies to decrease the size of their research labs.Even though some industries are downsizing some government agencies are looking for chemist to fill non laboratory chemistry positions. This profession fits me because I like coming up with new things and I like communicating with other to produce something that not only benefits us but benefits other people. This also fits my education because I actually would like to get majors in chemistry to either teach it or get a job that involves chemistry. Bachelor Degree at the very least. Most have earned a master's or doctoral degree. Bachelor of Science in chemistry or chemical engineering. Personal Characteristics Education They apply their chemistry training to new pharmaceutics and improve them.Most of the chemist work with other scientist such as biologist, toxicologist,pharmacologist, theoretical chemistry and many more. Together they come up with new techniques to apply and test in new drugs developing a effective environmentally means of production. Medicinal Chemistry Wages & Benefits Chemist must enjoy different activities and be determine in exploring new things or the unknown. Having a big imagination and persistence are two important qualities for this job. You must aldo be a social person and have good communication skills. Be a good writer and most important be a team player. Work Settings By:Karla Alfaro The benefits of this job is that you get to collaborate with different scientist and you gain more knowledge of the different drugs that are being produced. Also with the knowledge that you gain you can study to be another thing related to chemicals. Job Descriptions/Duties They offer many varieties of lab opportunities.Many chemist use this to research their skills to formulate,produce, and analyze new compounds. Each lab is unique not all study the same things. Some explore a compounds different mechanisms and some review drug applications. Employment Outlook Personal Assessment

Medicinal Chemistry

Transcript: Medicinal Chemistry Index Effects Kalkidan Bulbula There are five ways of administering a drug: 1. Injection a. Intravenous – veins b. Intramuscular – muscles c. Subcutaneous – under skin 2. Orally – mouth 3. Rectally – anus 4. By inhalation 5. Topically – on the skin (ointments, creams, …) Research 1. First the drug must be isolated or synthetized. 2. The drug is tested on animals. LD50 and ED50 are determined. 3. The drug moves to Clinical Trials a. Human Pharmacology – testing on small group of healthy volunteers for safety b. Therapeutic Exploratory – evaluates drug’s efficiency and side effects c. Confirmatory Stage – large-scale testing of drug 4. A local drug regulatory agency approves a medicine and decides whether it will be 5. OTC (over the counter) or on prescription only. Vocabulary Therapeutic window – the difference between the effective dose and lethal dose; also called therapeutic index Side effects – the undesired effects of drugs Ex: aspirin thins the blood (used as an anti-clotting agent to prevent a hearth attack) Morphium, the pain reliever, causes constipation. Tolerance – a person taking a drug often gets used to the active ingredient, so it takes larger and larger doses to obtain the drug’s desired effect. There is a danger that a body would create a physical addiction to a drug. For instance, an addiction to caffeine: if the addict does not get his/her coffee, he/she gets headaches. Another issue is that with increasing dose, the user is coming closer and closer to the lethal dose. Risk-to-benefit ratio – determines whether the side effects (risk) of the drug are acceptable in relation to its curing effects; for example, a drug curing baneful disease would be accepted despite high risks Methods of Administration LD50 is a lethal dose necessary to kill 50 percent of animal population. ED50 is an effective dose, one creating a noticeable effect in 50% of animal population. The ratio between LD50 and ED50 is called the Therapeutic Index. Therapeutic Index = LD50 / ED50 Therapeutic determines a safety of drug. If the therapeutic index of a drug is 10, a person would have to intake ten times more drug than the effective dose for the effects to be lethal. According to the therapeutic index, the researchers decide whether a dosage must be controlled. If TI is low, the dosage must be closely controlled. During testing, half of the patients receive a real drug and the other half similar-looking placebo. This determined whether the drug has a real effect or the pill only fooled body into healing. Drug or medicine is a substance that does one or more of the following: · Alters physiological state – consciousness, activity level, coordination · Alters incoming sensory experience · Alters mood or emotion The active ingredients in drugs and medicines can be isolated from a plants and animals or synthesized artificially. Drugs supposed to assist human body’s natural self-healing capabilities. Placebos are drugs containing no active ingredient, which “fool” the human body into healing.

Medicinal Chemistry

Transcript: Description Medicinal chemistry is using chemical research techniques to the synthesis of pharmaceuticals. Scientists were more concerned with the osolation of medicinal agents found in plants. Now a days scientists in medicinal chemistry are also concerned with the creation of synthetic drug compounds. This field is connected to ward drug discovery and development. Medicinal chemistry can lead to treatment of diseases wich I find very interesting. Training Most of the training required is a post doctoral fellowship which is taken in 2 years or more after recieving a PH.D in chemistry. The training for medicinal chemistry would be at a university level such as the university of Toronto Post Secondary In university the courses core subjects are biochemistry, anatomy and immunology which provides you with a understanding of the pharmacetical field. The main subject is organic chemistry where you work with organnic compounds. High School Required Courses Biology-as many biology courses as possible Chemistry- at least 4 semesters of chemistry at academic level Math- at least three years "In early 1975, the peroxide structure of yingzhaosu(2)27 inspired researchers that qinghaosu might also be a peroxide compound.The hypothesis was confirmed by simple qualitative analysis" Medicinal chemistry of bioactive natural products by- Xiaotain Liang, Wei-Shuo Fang pg 187 Bibliography http://portal.acs.org/portal/acs/corg/content?_nfpb=true&_pageLabel=PP_ARTICLEMAIN&node_id=1188&content_id=CTP_003395&use_sec=true&sec_url_var=region1&__uuid=6e6b911c-7348-4e9a-936e-d91a238a068e http://www.microbiotix.com/medicinalchemistry.htm the big picture http://medchem.rutgers.edu/mc501/pdfs/mc501_syll.pdf some techniques http://books.google.ca/books?id=yUGL1pdHfRcC&pg=PA187&dq=Medicinal+Chemistry+qualitative+analysis&hl=en&ei=K9i2TqTdE8nt0gGys4HJDQ&sa=X&oi=book_result&ct=result&resnum=6&ved=0CFAQ6AEwBQ#v=onepage&q=%20qualitative%20analysis&f=false book http://www.ehow.com/facts_4925339_courses-high-school-become-pharmacist.html courses in highschool http://portal.acs.org/portal/acs/corg/content?_nfpb=true&_pageLabel=PP_ARTICLEMAIN&node_id=1188&content_id=CTP_003395&use_sec=true&sec_url_var=region1&__uuid=f0e242bf-46f6-437a-beb9-eebb4af27429 training and what you would study http://joannekimkim.glogster.com/mc-description/ second picture Medicinal Chemistry http://www.microbiotix.com/medicinalchemistry.htm Some specific techniques include: thermodynamics, kinetics, isotope effects acids and bases substituent effects literature searching laboratory safety record keeping reaction mechanisms -additions -elimination -substitution -rearrangements -pericyclic reactions http://portal.acs.org/portal/acs/corg/content?_nfpb=true&_pageLabel=PP_ARTICLEMAIN&node_id=1188&content_id=CTP_003395&use_sec=true&sec_url_var=region1&__uuid=f0e242bf-46f6-437a-beb9-eebb4af27429 http://portal.acs.org/portal/acs/corg/content?_nfpb=true&_pageLabel=PP_ARTICLEMAIN&node_id=1188&content_id=CTP_003395&use_sec=true&sec_url_var=region1&__uuid=6e6b911c-7348-4e9a-936e-d91a238a068e http://medchem.rutgers.edu/mc501/pdfs/mc501_syll.pdf http://www.ehow.com/facts_4925339_courses-high-school-become-pharmacist.html

Medicinal Chemistry

Transcript: -There is no particular product that every medicinal chemist makes because they all work together with other fields of expertise to make small steps towards some kind of cure for different diseases, viruses etc. 2. What would be the titles (s) given to individuals working in you field? -Individuals working in this field of chemistry are called Medicinal Chemists. Magnesium sulfate is highly toxic and has polluted a lot of freshwater areas. People working at water treatment plants have has to pay closer attention. This means... In medicinal chemistry, 5-Fluorouracil is a chemotherapy drug. This chemical is classified as an anti metabolite, which means that it stops cells from dividing thus stopping any spreading of cancer. Calcium carbonate is an antacid. It treats heartburn, upset stomachs and indigestion by lowering the amount of acid in the stomach. Magnesium sulfate can be used as an anti inflammatory. It's found in Epsom salts and works to relieve tension in muscles. Also used to treat low levels of magnesium and to treat seizures in pregnant women. - Pharmaceutical companies prefer to hire people with advanced degrees. - Required to have either a Bachelor Degree of Science in Chemistry or a Bachelor of Chemical Engineering Medicinal chemists with a PHD receive a salary of $60,000-$90,000 a year There actually aren't many jobs in this industry. The End!!! By Madi Bowman & Angela Chimienti - Pharmaceutical companies have started downsizing and combining research labs because of our changing government and economy. 1. What products are created by those working in your career/ field? 3. Name at least two of the important chemicals used in this field. - Masters and Doctorate Degrees are highly recommended. - There are also undergraduate courses as well as graduate courses which include hands on training. 7. Interesting Notes/ Facts about Medicinal Chemistry Medicinal Chemistry Calcium Carbonate does not cause negative effects on the environment. It creates caves when mixed with water. Majority of working medicinal chemists have a degree in organic chemistry rather than medicinal chemistry. 5. What are the environmental impacts of these chemicals and what is done to help reduce any damage to the environment? 4. Why are the above chemicals used in your field? Medicinal chemistry uses the majority of the elements and compounds known to man. Some examples are: -5-fluorouracil -Calcium Carbonate -Magnesium Sulfate Thank you! 5-FU has been found in the waste water of hospitals. To help reduce damage, doctors have been left over product in separate waste bins. 6. What level of education is needed for an individual to work in your career/ field?

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