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Epipedobates Tricolor

Transcript: The Poison Size: 2-3 cm Diet - small arthropods, including insects like fruit flies and ants. A high majority is of Pumiliotoxin-containing ants (1). Location - Forests of southwestern Ecuador and northwestern Peru (2). Life Cycle - Eggs hatch and the male frog brings the tadpoles to the water where they grow into adult frogs. Family Tree - Animalia Chordata Amphibians Anura (Frogs) Dendrobatidae (Poisonous Frogs) Epipedobates Tricolor Defensive Weapon - The phantasmal poison frog secretes an alkaloid from its skin. The frog accumulates the alkaloids from the many ants that it eats. It will only produce its poison if fed the right ants in captivity. Frogs that are captured maintain poison levels for years (1). The poison is called epibatidine, named in honor of the frog. If an organism brushes the frog, the poison will be absorbed in through the skin. The LD50 of epibatidine is .4 µg, which is 200x more potent than morphine 1. Saporito, R., Garraffo, H. M., Donnelly, M., Edwards, A., Longino, J., & Daly, J. (2004, May 5). Formicine ants: An arthropod source for the pumiliotoxin alkaloids of dendrobatid poison frogs. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC419554/ 2. Poison frogs: Dendrobatidae - phantasmal poison frog (epipedobates tricolor). (n.d.). Retrieved from http://animals.jrank.org/pages/152/Poison-Frogs-Dendrobatidae-PHANTASMAL-POISON-FROG-Epipedobates-tricolor-SPECIES-ACCOUNTS.html 1. Strong, S. (1998, May 1). Altering chemistry: Epibatidine a novel alkaloid. Retrieved from http://wwwchem.csustan.edu/chem4400/sjbr/strong98.htm This means that .4 µg is enough to kill 50% of a population (3). Natural History Histrionicotoxin is very similar to epibatidine Phantasmal Poison Frog 1. Daly, J., Secunda, S., Garraffo, H., Spande, T., Wisnieski, A., & Cover, J. (1994, June 6). An uptake system for dietary alkaloids in poison frogs (dendrobatidae). Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/7940573 2. Strong, S. (1998, May 1). Altering chemistry: Epibatidine a novel alkaloid. Retrieved from http://wwwchem.csustan.edu/chem4400/sjbr/strong98.htm 3. Louissaint, P. (2008, September 18). Epibatidine: Nature’s pain reliever. Retrieved from http://chemgroups.ucdavis.edu/~shaw/CHE_150_2008/DHC-Website/Epibatidine_LouissaintP.pdf Mode of Action (2) (1) Lets learn about this little fella. Epibatidine binds to a neuronal nicotinic receptors in the brain. This desensitizes the receptor from receiving any of the natural ligand, acetyl choline (1). This effectively shuts down the muscle control system and paralyzes the victim, leading to die of asphyxiation. Accidental poisonings of humans are treatable by putting them on a ventilator until the effects of the poison wear off. There is no medical uses of epibatidine, but a compound that was synthesized from it called ABT - 594 is being tested for a pain relieving medicine (1). Epipedobates Tricolor

TriColor Initiatives

Transcript: TriColor Initiatives TCI? Unique Edge?? What is it going to be? TCI Skills and knowledge: What do I know Comprehensive knowledge of both the Salesforce and Mulesoft platforms Deep understanding of how mule cost structures Insight into the mismatch between the services offered and needed Skills and knowledge Clearest Problems Inefficient Use of Resources Service mismatch. Fascinations and passions What am I doing when I am at my happiest? Spending quality time with family, particularly the kids, and going on trips provide a great source of happiness. Fascinations and passions What do my friends and colleagues complain about that I find effortless? Finding solutions to complex problems seems What do other people say I am great at, or comes naturally to me? Ability to make things work, particularly in a technical context. Reputation for being a go-to person when something needs to be done right. Additional passions and interests: Deep passion for the middle class and farmers. Strong aversion to poor service in any context Why now? Rapid Digital Transformation: According to a 2021 report, 88% of IT leaders accelerated their digital transformation initiatives in the wake of the COVID-19 pandemic, And Digital Transformations on an average goes for 5+ years Increasing Demand for Client-centric IT Services: Report from Microsoft found that 96% of customers say customer service is an important factor in their loyalty to a brand. This reinforces the market need for a more client-focused approach in the IT services industry Why now? Regulatory Changes and Business Adaptability: Report from Gartner found that by 2023, 65% of the world’s population will have its personal information covered under modern privacy regulations, up from 10% in 2020. This indicates an increasing need for businesses to comply with complex data privacy regulations Customer Discovery Jobs to be Done Top Problems Solutions Value Proposition Customer Discovery Problems Problems Solutions Solutions Value Proposition TCI addresses the pain-points of complex IT challenges and upskilling, providing efficiency, peace of mind, and increased team competency, Value Proposition by delivering tailored Mulesoft solutions, 24/7 support and on-demand training that differentiate us from traditional IT service providers. Risky Assumptions Delivery Side Client Acquisition Side Current State Risky Assumptions Delivery Side Delivery Client Side Clients Current State Client Acquisition and Retention: I can effectively attract new clients, satisfy their needs with my services, and retain them over the long term. Sales Rep Relationships and Referral Consistency: I can establish strong relationships with Mulesoft sales reps who will consistently refer clients to me. Current State Reputation Building and Competitive Differentiation: I can build a strong reputation among other Mulesoft partners and differentiate my services in a meaningful way. Lean Canvas Lean Canvas First Iteration Stuff Current State V 0.1 V 0.1 Stuff Stuff Talking to people - MOM Tests Reading reports. Talking to Experts OneDay Teachings SF PAMs and AEs The Lean Canvas V 1.0 Overstatement and underperformance of Mulesoft tasks by service providers. Difficulty for service providers in adhering to client procedures and standards. Unexpected rise in the costs of Mulesoft licenses. Heads of Mulesoft verticals within non-IT companies. Senior IT Project Managers overseeing Mulesoft projects. IT leaders in companies undergoing digital transformation. A team committed to fulfilling client requirements while minimizing license costs. My way of working on Mulesoft, the way in which we can deliver what matters keeping the reduced license cost. Thinking in terms of Mulesoft, Not JAVA or SF. Mulesoft license cost optimization strategies provided. Highly competent team aligned with client needs and desires. Unique focus on Mulesoft, unlike other providers who integrate it with Salesforce or JAVA. Client API traffic/license usage. Duration of client retention. Number of clients experimenting with other vendors but returning to our services. Ratio of successfully delivered projects to total projects undertaken. Mulesoft/SF Partner Account Manager and Account Executives. Events Cold Emails + LinkedIn Provision of services. Consultancy offerings. Support through Catalyst. Training programs. Employee remuneration costs. Expenditure on training and certification programs. Costs associated with internal projects. Expenses related to employee welfare and satisfaction Great IT services The best IT Services Provider Initiatives Ton of Great Executions Enhanced Farmer Income Enhanced Middle Class standards . . . . . A better and a more sustainable world

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Transcript: Wisdom does not flow like water Plato’s Critique of Pederasty Pederasty Background Symposium Pederasty My Project Pausanias' Speech Pausanias' Speech Two Aphrodites Uranian Heavenly Pandemos Common Text Text Pictures Pictures "Here, Socrates, lie down alongside me, so that by my touching you, I too may enjoy the piece of wisdom that just occurred to you while you were in the porch. It is plain that you found it and have it, for otherwise you would not have come away beforehand." Agathon and Socrates “It would be a good thing, Agathon, if wisdom were the sort of thing that flows from the fuller of us into the emptier, just by our touching one another, as the water in wine cups flows through a wool thread from the fuller to the emptier. For if wisdom too is like that, then I set a high price on my being placed alongside you, for I believe I shall be filled from you with much fair wisdom. My own may turn out to be a sorry sort of wisdom, or disputable like a dream; but your own is brilliant and capable of much development, since it has flashed out so intensely from you while you are young; and yesterday it became conspicuous among more than thirty thousand Greek witnesses." "You are outrageous, Socrates," Agathon said. "A little later you and I will go to court about our wisdom, with Dionysus as judge, but now first attend to dinner." how water flows Principle at play When they do engage in a contest about love Timeline YEAR Alcibiades' Speech Socrates, he claims, is like “those silenuses that sit in the shops of herm sculptors, the ones that craftsman make holding reed pipes or flutes; and if they are split in two and opened up they show they have images of gods within.” (215b) Alcibiades' Speech You, in my opinion,' I said, 'have proved to be the only deserving lover of mine; and it seems to me that you hesitate to mention it to me. Now I am in this state: I believe it is very foolish not to gratify you in this or anything else of mine—my wealth or my friends—that you need; for nothing is more important to d me than that I become the best possible; and I believe that, as far as I am concerned, there is no one more competent than you to be a fellow helper to me in this. So I should be far more ashamed before men of good sense for not gratifying a man like you than I should be before the many and senseless for gratifying you.' Seduction Scene 'Really, my dear Alcibiades, you're no sucker if what you say about me is really true and there is some power in me e through which you could become better. You must see, you know, an impossible beauty in me, a beauty very different from the fairness of form in yourself. So if, in observing my beauty, you are trying to get a share in it and to exchange beauty for beauty, you are intending to get far the better deal. For you are trying to acquire the truth of beautiful things in exchange for the seeming and opinion of beautiful things; and you really have in mind to exchange "gold for bronze." But blessed one do consider better: Without your being aware of it—I may be nothing. Thought, you know, begins to have keen eyesight when the sight of the eyes starts to decline from its peak; and you are still far from that.' Conclusion conclusion If Socrates were to have sex with Alcibiades, he would perpetuate: 1) the idea that people can make each other wise. impact: prevent Alcibiades from realizing his ignorance about wisdom 2) Alcibiades belief that his physical attractiveness is the most important thing about him impact: the belief could harm Alcibiades as he begins to decline from his physical peak, when “Thought begins to have keen eyesight.” (219a) 3) Socrates would be no better than the sophists who cannot acknowledge the ways in which they are ignorant, and thus, risk self-deception. Advantages Advantages to my account: -Fits with the well-known picture of a Socrates who: 1) proclaims his own ignorance. 2) critiques the Sophists for i. both not acknowledging what they do not know ii. exchanging money for wisdom -Makes explicit the way Plato critiques the customs of his time -Throws into question a vision of Socrates as someone who consistently denies bodily urges -Makes clear that the container model is supposed to function in opposition to the image of pregnancy and birth. Accounts of “Plato’s Appropriation of Reproduction” run these two images together.

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