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Transcript: ADVANTAGES AUTOMATED WORKFLOWS COMPLIANCE OUR STORY WOUND KITS The lessons learned on the journey to get where we are today helped us acquire the knowledge and perspective that shaped the foundation of our company: THE ACE UP OUR SLEEVE MARKET REACH CATALYST ANCILLARY SOLUTIONS STREAMLINED PROCESSES DESIGN ELEMENTS: 5 Hospital Systems Benefit Verification Pre-authorization Coding & Dictation Guidance Recoupment Protection & Denial Defense OFFICE APPLICATIONS ENTRY OPPORTUNITIES SUBTITLE PROGRESSIVE WOUND CARE PLATFORM "Be a yard stick of quality; some people aren't used to working in an environment where excellence is expected." PREPARATION & PROCESS 12 Surgery Centers ACCESS TO HMS WOUND CARE DATA STRATEGIC SALES STRATEGY 2 Wound Care Centers 1 Cancer Center We help medical practices thrive by improving continuity of care and growing practice revenue "Tact is the ability to tell someone to go to hell in such a way that they look forward to the trip" - Churchill INTEGRITY SUPPORT Easily integrated and adopted "If opprtunity doesn't knock, build a door" DIRECT ACCESS TO PHYSICIANS, ADMINISTRATORS, AND C-LEVEL EXECS THROUGHOUT THE REGION "Give me six hours to cut down a tree and I'll spend the first four sharpening the axe." WOUND KITS EXPERIENCE & CAPABILITY SURGICAL APPLICATIONS Using technology to ensure efficiency REIMBURSEMENT Personal Development & Constant Learning ESTABLISHED CREDIBILITY PATHOLOGY "Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum" COMBINED 14 YEARS OF EXPERIENCE IN MEDICAL SALES WHAT SETS US APART GROWTH & STABILITY THROUGH DIVIRSITY OUR VALUE "The illiterate of the 21st century will not be those who cannot read and write, but those who can't learn, unlearn, and relearn" - Alvin Toffle OUR SOLUTIONS HEADLINE 300+ Physician Contacts Finding the need behind the need OUR METHOD REIMBURSEMENT SUPPORT dme/ccm diagnostics ADD COLORS 500+ ICONS wound care biologics


Transcript: November, 30, 2017 How Biologic Medicines are Made What Are Biologics Biologics are proteins derived from living sources. They are not new medicines, because it has been used for years and extracted from our bodies cells which are living sources. What Are Biologics First 3 steps Step1: The process starts with the insertion of genetic material into “chinese hamster ovarian cells” or C.H.O. They keep them frozen in liquid nitrogen. Step2: Then in the seed lab, a technician thaws the cells in warm water. Then it is transferred to a glass flask that contains growth media.---It’s a recipe of nutrients and vitamins to help the cells multiply. Step3: The team injects the mixture into a five gallon capacity bioreactor. First 3 steps Step 4: Inside, a propeller agitates the mixture to stimulate growth. Over a 3 week period, the number of cells increase exponentially. After the cells are done growing, each new cell is programmed to produce the target protein. Step 5: Next, a technician measures salts and other dry ingredients. They preparing the recipe to purify the protein liquid once it’s been separated from the cells. The guy labels the bag and records the information separately. Step 6: He adds the ingredients to a purifying mixing tank. After separating the cellular materials from the protein mixture, The amp pumps it through steel and glass columns. There the purification solution works with resin beads to separate the protein from the impurities. Next 3 Steps The technician takes a sample and conducts a test to ensure the medicine is sterile and then it’s sent to hospitals. It’s sent from the factories that make the medicines and to the hospitals and they are given to the doctor and then given to patients. Where Does it Go? What is the consumer classification of this product - Convenience goods, shopping goods or specialty goods? I guess it’s specialty goods since it comes from cells and it’s not often that medicine is made from the cells in our bodies. How is this product used? It is used to “save People’s lives” and patients in need of this medicine. Where is this product sold? I don’t think there’s a specific place that it is sold since it is a medicine and it’s usually for patients in absolute need so maybe a business that is tied with hospitals are buying it and then it’s sent to hospitals. Six Steps of Production Six Steps of Production Planning- The scientist gather their tools tio prepare for the long process of making bilogical medicine Purchasing- They don't purchase anything because these are products used from human biology. Production Process- There is a process pof about six things to do to make the medicine. Schedule- They have to find places to ship the medicine at a certain amount of time to know how much to send. Dispatching- The medicine is then sent out to the hospitals that have purchased the product. Follow Up- They do the process all ovee again after the medicine is sent out. The six steps: The six steps:


Transcript: Genesis BIOLOGICS GENESIS Dayton Orthopaedic Surgery Sports Medicine Center Office Locations Far Hills North Dayton Springfield West Chester Troy Meet the Team MOVE TO END Jennifer Leibold, PA-C 250 years Jonathan Paley, M.D. over 25 Skippy, PA-C Education: GED Total joint Replacement Shoulder Reconstruction Sports Medicine Stem Cell Biologics and Joint Restoration Services Provided MOVE TO END Carpal Tunnel Foot and Ankle Neck and Back Workers Compensation BIOLOGICS Orthobiologics involves the field of stem cell research. This typically involves the harvest of stem cells from either adipose tissue, bone marrow cells and from the actual blood itself. These stem cells, are able to differentiate into tissue that resemble normal cartilage or tedon. Orthobiologics is used to excel the healing process of joint repair, broken bones or tendons and ligaments that have been injured. ORTHOBIOLOGICS A global medical device company and leader in new product development and medical education in orthopedics Over 11,000 innovative products and surgical procedures more than 90% of all products made within the US BIOLOGICS *ASK ABOUT VIDEO AT END OF PRESENTATION* What We Need What We Offer How does Dayton Orthopaedics utilize Biologics? PRP BMA Angel PRP Platelet Rich Plasma Two types of PRP Rich Leukocyte- Tendons 1 shot seires Results seen as quick as 3-5 days Poor Leukocyte- Joints 3 shot series Results seen as quick as 1-2 weeks The use of a portion of the patient's own blood having a platelet concentration to promote quicker healing of injured tendons, ligaments, muscles, and joints. *ASK ABOUT VIDEO AT END OF PRESENTATION* BMA Bone Marrow Aspirate One shot seires for BOTH joints and tendons Marrow taken from Pelvic bone Numb the Periosteum Extract Marrow Re-injected to the troubled area of the body Involves taking a sample from the soft tissue inside of the bone. Bone marrow is the spongy tissue found and contains cells that produce white blood cells, red blood cells, and platelets. Results as quick as 6 days Angel System The Angel System How it's Done The Angel System utilizes a proprietary platelet sensor and one button automation to prepare customized platelet-rich plasma formulations -Reduce invasive surgical procedures - Products are naturally found within the patient body -Reduces chance of infection or rejection -Outpatient procedure that is more rapid in recovery time than surgery -Minimizing impact of degenerative disease and more BENEFITS QUESTIONS? REMEMBER. IF IT'S NOT GREAT, WHY BOTHER? Arthrex Introduction


Transcript: Zoom out for more assets Asset library CRISPR Babies In November of 2018 a chinese scientist , He Jianku, used CRISPR to genetically engineer, a set of embryonic twins, to give them HIV resistance. Scientists sent to prison for 3 years, the twin girls are still alive and doing well today. Raised question if embryonic cells should be gentically modfied ONLY if it is for health purposes. Applications Clincal trial "cured" 39/49 ß thalassemia and 28/29 SCD patients U.K approved CRISPR treatment for these diseases in 2022 FDA approvved of same treatment for SCD in December of 2023 CRISPR/CAS 9 Gene Editing CRISPR is a genomic region and CAS 9 is a protien in many proaryotic cells Together they work as a immune response which can cut virus out. This process can be done to edit human genes Vaccines Recombinant DNA Discovered by Edward Jenner by infecting a boy with coxpox and then smallpox Traditional vaccines work by introduing a deactivated virus into your body for reconginition Mrna Vaccines ; COVID vaccine When a gene from one organism is put into a differnt type, to be expressed Discovered by Herbert Boyer and Stanley Cohen in 1972 Human Insulin is made by giving the human gene to the bacteria E. coli Antibodies A protein produced by B lympocytes, which will match with a pathogen's antigen Cancers and viruses like HIV have a ways to avoid the immune system CAR-T Cells and Monoclonol Antiboies Too expensive for most Biologics are medicines that are manufactredred in, dervied from, made from (ect.) from living organisms Embryonic Stem Cells All the United States embryonic stem cell lines come from left over IVF cell, with consent from donor Embryonic stem cells are pluripotent Nuclear Transfer Embryonic Stem Cells Induced Puripotent Stem Cells Antibiotics Immunotherapy Discovered in 1928 by Alexender Flemming by accident Without antibiotics we would have to take wounds and imjuries much more seriously Produced by bacteria and fungi Therapy and treatment using the person's own immune system to fight disease Biologics Seth Boone


Transcript: Biologics or Immunizing biologicals - derivatives of animals (serums, antitoxins, globulins) or microorganisms (vaccines, toxins, toxoids, tuberculins) confer a state of protection against pathogenic microorganisms. Classification of Immunity I. Natural (Innate) Immunity - endowed at birth and is retained because of race and other factors. II. Acquired Immunity - developed or acquired during the lifetime. Subdivided into two classes. 1. Active Immunity a. Naturally acquired active b. Artificially acquired active 2. Passive Immunity a. Naturally acquired passive b. Artificially acquired passive A. Viral Vaccines 1. Measles (Attenuvax), Live, attenuated Rubeola virus, grown on avian or human cell tissue culture. 2. German Measles (Meruvax II) Live Rubella virus, grown on human diploid cell tissue culture. 3. Mumps (Mumpsvax) Live Mumps virus, Chicken embryo tissue. 4. Smallpox or Vaccinia (not available commercially) Live vaccinia-cowpox- virus, skin of bovine calf 5. Poliovirus (TOPV)- Trivalent oral polio vaccine live - Only under special conditions due to vaccine associated paralytic polio- Guillain-Barre Syndrome. 6. Poliomyelitis (IPV) Inactivated polio vaccine trivalent, Rhesus monkey kidney tissue culture 7. Rabies (Imovax, RabAvert) Inactived rabies virus, Imovax - human diploid cell (HDC) & RabAvert - chicken fibroblasts tissue culture. 8. Influenza (Fluzone, FluShield, Fluvirin) Inactivated Influenza virus, seasonally selected types 9. Yellow Fever (YF-Vax) Live, attenuated yellow fever virus, domestic fowl embryo. 10. Hepatitis A, Inactivated(Havrix, Vaqata) Inactivated surface antigen particles obtain from the plasma of healthy chronic hepatitis B antigen carrier by plasmapheresis. 11. Hepatitis B, Recombinant (Recombivax HB, Engerix-B) Recombinant HB surface antigen 12. Chickenpox or Varicella (Varivax) Live, attenuated varicella virus human diploid cell culture 13. Japanese Encephalitis (JE-Vax) Inactivated JE virus, prepared from infected mouse brain. B. Bacterial Vaccines 1. Typhoid (Typhim-inj, Vivotif Berna- oral) Salmonella typhi, killed bacelli 2. Cholera (CDC source) Vibrio cholera, killed bacteria 3. Plague (CDC source) Yersinia pestis, killed bacilli 4. Tuberculosis - BCG Vaccine (Tice BCG) Mycobacterium tuberculosis, living culture of bacillus Calmette-Guerin strain. 5. Pneumococcal polyvalent (Pneumovax 23, Pnu-Imune 23) Streptococcus pneumoniae, capsular polysaccharide from serotypes listed 6. Meningococcal Polysaccharide (Menomune A/C/Y/W-135) Niesseria meningitidis, capsular polysaccharide from different serotypes 7. Hemophilus b Polysaccharide (HibTITer, ActHIB) Heamophilus influenzae, capsular polysaccharide. 8. Pertussis (CDC source) Bordetella pertussis, killed bacteria, both fluid and adsorbed forms 9. Lyme Disease (CDC source) Borrelia burgdorferi, outer cell surface protein by recombinant technology C. Rickettsial vaccines These can only be obtained from CDC 1. Typhus - Rickettsia prowazeki - inactivated, chicken embryo origin 2. Rocky Mountain Spotted Fever - Rickettsia rickettsii, - Killed, chicken embryo origin 3. Rickettsial pox- Rickettsia akari - Killed, chicken embryo origin 4. Typhus- Scrub aka Tsutsugamushi Disease - Rickettsia Tsutsugamushi, Killed, chicken embryo origin 5. Q Fever - Coxiella burnette, whole cell culture 6. Trench Fever - Rickettsia quintana, whole cell culture A number of antigen-containing preparations are employed in diagnostic aids to determine whether an individual has developed hypersensitivity to certain types of organism Small quantity preparation usually injected intradermally developing reaction usually read at 48 hours Commonly available in : tubeculin,histoplasmin,coccidiodin,diptheria toxin, and mump skin test Preparation obtain from human and bovine strains of the tubercle strains It is applied as a diagnostic agent to determine whether the person animal is or has been infected with Mycobacterium Applied intracutaneous injection, by rubbing into the scarified skin, dropping into the eye is another method A sterile solution of concentrated, soluble products of growth of the tubercle bacillus (Mycobacterium tuberculosis) Used to test patient suspected with tuberculosis Usual dose 5 units ,administered intradermally The test is read after 48 to 72 hours after administration Sterile, standardized liquid concentrate of the soluble growth products by the fungus(Histoplasma capsulatum ) No value of treating disease Used in determining whether patient is harbouring fugal organism Stored between 2 to 8˚C The expiration is two years after date of manufacture or date issue 0.2 ml,intradermally into the flexor surface of the forearm Steril solution containing antigens from by products of the mycelial growth or form the spherules of the fungus (Cocciodis immitis) Used for detecring coccidomycosis Usual dose,intradermally is 0.1 ml of a 1:100 dilution Diptheria toxin Sterile solution of the diluted, standardzed products of growth of diptheria

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