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Transcript: Marfan Syndrome Principles of Epidemiology / Bre Hunter 04/02/2020 Introduction Syndrome Introduction Marfan Syndrome is a genetic disorder that affects the body's connective tissue (CT) and causes excessive growth. (Marfan Foundation, 2014) Connective tissue (CT) is what holds cells, organs, and other body tissues together, making it important for proper growth and development (Marfan Foundation, 2014) Found throughout the body, this disorder can cause abnormalities in many parts including the heart, blood vessels, bones, joints, eyes, lungs, skin, and nervous system (Marfan Foundation, 2014) FBN1 Gene Causes Marfan syndrome is caused by a mutation in the FBN1 gene (National Library of Medicine, 2020) This gene provides instructions for making the protein fibrillin-1, which bind to form microfibrils that provide strength and flexibility to connective tissues (NLM, 2020) They also release and control growth and repair hormones for tissues and organs in the body (NLM, 2020) The mutation reduces the amount of fibrillin-1, which decreases microfibril formation (NLM, 2020) The lack of microfibrils leaves excess growth factors and decreased elasticity, which leads to overgrowth and instability of tissues (NLM, 2020 Inheritance Pattern Inheritance As stated, Marfan Sydrome is genetic. It is inherited in an autsomal dominant pattern, where one copy of the altered gene in each cell is enough to cause the disorder (National Library of Medicine, 2020) At least 25% of the cases result from a new mutation in the FBN1 gene (NLM, 2020) These cases occur in people with no family history of the disorder (NLM, 2020) Signs & Symptoms Signs & Symptoms Signs of Marfan Syndrome can appear at any age, starting as early as birth or later in life (Marfan Foundation, 2014) Some signs are progressive and can get worse over time/or without treatment (Marfan Foundation, 2014) Every person's experience can vary, some showing more features and some with different combinations of features (Marfan Foundation, 2014) These different factors make it important for ongoing monitoring (Marfan Foundation, 2014) Marfan Syndrome does not affect intelligence (Marfan Foundation, 2014) Easy-to-see Signs Easy Signs Long arms, legs and fingers Tall and thin body type Curved spin Chest sinks or sticks out Flexible joints Flat feet Crowded teeth Stretch marks unrelated to weight gain or loss (Marfan Foundation, 2014) *These features can be categorized as mild or severe, and may show up in different combinations (Marfan Foundation, 2014) Hard-to-see Signs Harder Signs Heart problems Aortic enlargement can cause aneurysm, tears in the layers of aorta (dissection), and "floppy" mitral valve Sudden lung collapse Eye problems severe nearsightedness, dislocated lens, detached retina, early glaucoma, and early cataracts (Marfan Foundation, 2014) *These features often need special tests to be detected.(Marfan Foundation, 2014) What it Looks Like Some examples of what Marfan Syndrome may look like in some individuals are provided here: What Marfan Syndrome Looks Like Transmission / At Risk Transmission / At Risk As stated earlier, this a genetic disorder so it cannot be transmitted any other way than through genetics (NLM, 2020) Marfan Syndrome affects men and women equally among all races and ethnic groups (Mayo Clinic, 2019). The greatest risk factor is having a parent with the disorder (Mayo Clinic, 2019). Risks within the Disorder Risks and Complications Heart Conditions Eye Conditions Skeletal Conditions Lens dislocation can occur, where the focusing can move out of place (if support is weakened) This disorder increases the risk of detachment or tear in retina, which lines the back of the eye Early on-set glaucoma, which is increased eye pressure that can damage the optic nerve, and cataracts that cause cloudy areas (Mayo Clinic, 2019). Marfan syndrome increases the risk for abnormal curves in the spine, such as scoliosis It can also cause the breast bone to protrude or sink in, raising the risk for collapsed lungs Foot and lower back pain are also common (Mayo Clinic, 2019). The most dangerous complication and risk within this disorder involves the heart and blood vessels. Faulty connective tissue can weaken the aorta and cause rupture This condition can also be categorized as heart disease (Mayo Clinic, 2019). Disorder Incidence Incidence Marfan Syndrome is a rare disorder It happens in about 1 in 5,000 people worldwide One in four people with the disorder develops the condition for unknown reasons A person with Marfan Syndrome has a 1 in 2 chance of passing it on to their child (CDC, 2019) Statistics Statistics According to one study in 1999, 130 patients with Marfan Syndrome were evaluated. It was found that 5 and 10 year survival rate after diagnosis was 95% and 88%. The complication free survival rate was 78% and 66% Thirteen patients developed dissection, 30 underwent prophylactic repair, and 82 had an uncomplicated course (Groenink et al., 1999)
Transcript: and subtitle We have the conclusion. So make any final notes you can think of, within this box. Then make jokes. Tear off your break away pants. Party. Example Title Facebook Twitter LinkedIn Mustache Coalition And Finally, Mega Point #1 Social Media Because who doesn't? With Bullet Points Because People Love Bullet Points Also, Mustaches
Transcript: Sterilize Needles before Surgery Be careful of untested farm animals Large amounts of infected meat spread through store Not checking animals for MCD before selling meat of animals or milk of cows Contributing Factors Towards Outbreak Factors Towards Getting the Disease Symptoms There is no cure for this disease Recent Outbreaks Mad Cow Disease Tommy Henry Brandon Cox David Gentry Treatments Ways to Avoid Disease Anti-Social Trouble with walking Lose Weight Trouble with balance Fever Different kinds of MCD holes in brain Cool Fact Cause of Disease Wisconsin of 1947 Canada Finland Germany Former Republics of the Soviet Union Any General farm animal(Cows, sheep) Inheritance Mode of Transport Using unclean tools during surgery Eating infected meat Drinking infected cow milk Prion in the Brain The Prion in MCD make blockages in brain and explode, making holes in the brain
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Transcript: Wisdom does not flow like water Plato’s Critique of Pederasty Pederasty Background Symposium Pederasty My Project Pausanias' Speech Pausanias' Speech Two Aphrodites Uranian Heavenly Pandemos Common Text Text Pictures Pictures "Here, Socrates, lie down alongside me, so that by my touching you, I too may enjoy the piece of wisdom that just occurred to you while you were in the porch. It is plain that you found it and have it, for otherwise you would not have come away beforehand." Agathon and Socrates “It would be a good thing, Agathon, if wisdom were the sort of thing that flows from the fuller of us into the emptier, just by our touching one another, as the water in wine cups flows through a wool thread from the fuller to the emptier. For if wisdom too is like that, then I set a high price on my being placed alongside you, for I believe I shall be filled from you with much fair wisdom. My own may turn out to be a sorry sort of wisdom, or disputable like a dream; but your own is brilliant and capable of much development, since it has flashed out so intensely from you while you are young; and yesterday it became conspicuous among more than thirty thousand Greek witnesses." "You are outrageous, Socrates," Agathon said. "A little later you and I will go to court about our wisdom, with Dionysus as judge, but now first attend to dinner." how water flows Principle at play When they do engage in a contest about love Timeline YEAR Alcibiades' Speech Socrates, he claims, is like “those silenuses that sit in the shops of herm sculptors, the ones that craftsman make holding reed pipes or flutes; and if they are split in two and opened up they show they have images of gods within.” (215b) Alcibiades' Speech You, in my opinion,' I said, 'have proved to be the only deserving lover of mine; and it seems to me that you hesitate to mention it to me. Now I am in this state: I believe it is very foolish not to gratify you in this or anything else of mine—my wealth or my friends—that you need; for nothing is more important to d me than that I become the best possible; and I believe that, as far as I am concerned, there is no one more competent than you to be a fellow helper to me in this. So I should be far more ashamed before men of good sense for not gratifying a man like you than I should be before the many and senseless for gratifying you.' Seduction Scene 'Really, my dear Alcibiades, you're no sucker if what you say about me is really true and there is some power in me e through which you could become better. You must see, you know, an impossible beauty in me, a beauty very different from the fairness of form in yourself. So if, in observing my beauty, you are trying to get a share in it and to exchange beauty for beauty, you are intending to get far the better deal. For you are trying to acquire the truth of beautiful things in exchange for the seeming and opinion of beautiful things; and you really have in mind to exchange "gold for bronze." But blessed one do consider better: Without your being aware of it—I may be nothing. Thought, you know, begins to have keen eyesight when the sight of the eyes starts to decline from its peak; and you are still far from that.' Conclusion conclusion If Socrates were to have sex with Alcibiades, he would perpetuate: 1) the idea that people can make each other wise. impact: prevent Alcibiades from realizing his ignorance about wisdom 2) Alcibiades belief that his physical attractiveness is the most important thing about him impact: the belief could harm Alcibiades as he begins to decline from his physical peak, when “Thought begins to have keen eyesight.” (219a) 3) Socrates would be no better than the sophists who cannot acknowledge the ways in which they are ignorant, and thus, risk self-deception. Advantages Advantages to my account: -Fits with the well-known picture of a Socrates who: 1) proclaims his own ignorance. 2) critiques the Sophists for i. both not acknowledging what they do not know ii. exchanging money for wisdom -Makes explicit the way Plato critiques the customs of his time -Throws into question a vision of Socrates as someone who consistently denies bodily urges -Makes clear that the container model is supposed to function in opposition to the image of pregnancy and birth. Accounts of “Plato’s Appropriation of Reproduction” run these two images together.
Transcript: Assessment and management of stroke in the pre-hospital setting Sam, Sam, Shawn, Andy, Charlie & Owen WHAT There are three types of stroke: Transiant ischaemic attack (TIA) - Ischemic stroke and Hemorrhagic stroke (Stroke Association, 2017). The World Health Organisation,( 2017) deffines a stroke as, the interruption of the blood supply to the brain, usually because a blood vessel bursts or is blocked by a clot. This cuts off the supply of oxygen and nutrients, causing damage to the brain tissue. what is a stroke? Stroke classification what comorbidities or health risk factors lead to strokes or increase the risk of strokes? why do people experience strokes? why treatment how do we assess and treat stroke? FAST campaign and treatment pre-hospital / hospital epidemiology What are the UK and international statistics on stroke death and survival chart? bla bla bla! how can we as studet paramedics increase the quality of treatment for stroke patients? how References WHO. (2017). WHO | Stroke, Cerebrovascular accident. Available at: http://www.who.int/topics/cerebrovascular_accident/en/ [Accessed 2 Oct. 2017]. Stroke Association. (2017). Types of stroke. Available at: https://www.stroke.org.uk/what-stroke/types-stroke [Accessed 2 Oct. 2017]. Sibson, L. (2017). Stroke assessment and management in pre-hospital settings. Journal of Paramedic Practice, 9(8), pp.354-361. References
Transcript: IP Meeting with CDC Nigeria Dr. Christopher-Izere/ CIHP 27/11/yyyy Outline Outline Challenge 1 Update on Index Case Testing 1 Challenge 2 Linkage of positives from NAIIS lenge 2 Challenge 3 Update on Granular Site Management 3 ICT update ICT Update Trend 1 Trend 1 Trend 2 Trend 2 Trend 3 Trend 3 Solutions Solutions Solution 1 Solution 1 Solution 2 2 Solution Solution 3 3 Solution Solution 4 Solution 4 Working together Working Together Tiers of service Tiers of service Tier 1 Tier 1 Tier 2 Tier 2 Tier 3 Tier 3 Pricing Pricing Standard Standard Premium Premium FAQ FAQ
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