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Transcript: SSSRIs Fluoxetine & Fluvoxamine inhibit CYP-1A2, leading to failure to fully metabolize caffeine. Thus those people taking these antidepressants may experience toxicity, intolerance to caffeine, and ‘caffeinism.’ In cigarette smokers, caffeine’s half life is shortened; however, during smoking cessation caffeine’s half-life is extended. This mechanism may exacerbate cigarette withdrawal symptoms by inducing agitation. Energy Drinks Coffee Pills Also Tea and Chocolate (not pictured) Caffeine: the active ingredient By Tracy Markowitz Psychopharmacology Class November 12, 2012 Caffeine and You Caffeine As a vasoconstrictor, can constrict blood vessels thereby decreasing blood flow to the brain by 30% which can produce relief from headaches especially migraines. Caffeine can also produce an antiasthmatic effect or bronchial relaxation Caffeine has been associated with improved glucose tolerance and lower risk of type 2 diabetes Contains antioxidants Also produces alertness & can aid cognitive functioning by delaying fatigue Potential for Abuse The Many and Varied Forms of Caffeine Caffeine is primarily metabolized by the liver. Specifically, the CYP-1A2 enzyme metabolizes caffeine. as caffeine is broken down, metabolizes into theophylline & paraxanthine which behave similarly to caffeine. The third metabolite, theobromide does not produce caffeine like effects. Caffeine’s half-life can be from 2 ½ - 10 hours. Some are predisposed to longer caffeine half-life- taking longer to metabolize caffeine. “Slow metabolizers” may be more susceptible to negative effects of caffeine consumption Negative Pharmacokinetics Positive and Negative Effects of Caffeine Decaffeinated Teas and coffees still contain trace amounts of caffeine (5-15mg) An average cup of coffee contains 100 mg of caffeine Some energy drinks may contain as much as 300 mg of caffeine Treatment of Abuse (?) Caffeine is most often absorbed orally. As caffeine is water soluble, it equally disperses across all parts of the body. Maximum blood levels of caffeine are reached 30-45 minutes after imbibing Half life of caffeine is variable. Adenosine is a neuromodulator While there are not discrete and direct CNS pathways, gradual increase of Adenosine over the course of the day produces sedation by stimulation GABAergic neurons which act as an inhibitor to dopaminergic system Thus, when caffeine BLOCKS adenosine receptors, we see the effects that we all have come to know and love: wakefulness and increased mental acuity. Caffeinism How much is too much? Pharmacokinetics cont’d Adenosine Youtube clip: As previously discussed, caffeine only indirectly stimulates the dopaminergic ‘reward’ system; thus it does not possess the hallmarks of an addictive drug: interaction with nucleus accumbens and involvement in reward motivation and addition While caffeine does not possess the true potential for addiction, consumption of moderate to high levels of caffeine( more than 5 cups of 500 mg/day) will result in tolerance and withdrawal symptoms. Withdrawal symptoms include headache, drowsiness, and fatigue Only mildly behaviorally reinforcing: p. 52 As caffeine is not a true drug of abuse and dependence, there are no formalized treatments specifically designated for caffeine. Over the Counter Medication: Medications such as NoDox contain as much as 200 mg of caffeine per tablet Excedrin contains 75 mg Chewing Gum:Jolt Gum or ThinkGum typically contain 10mg of caffeine per piece Delicious: Chocolate: up to 25 mg per ounce Positive Adenosine’s Job: *Yawn* When intoxicated, caffeine does increases alertness Drinks like Vodka-Redbull or other alcohol & caffeine combinations create the feeling of being wide-awake- drunk As a behavioral stimulant, caffeine increases activity while the motoric and cognitive distortions produced by alcohol remain intact. The End Psychological Agitation Panic Can induce or intensify anxiety disorders Physical Nigh time Wakefulness Tremors Insomnia Gastrointestinal Upset Tachycardia Drug interactions On a molecular level, caffeine looks remarkably similar to the endogenous adenosine. Thus it binds to the adenosine receptors and becomes an adenosine antagonist by blocking these recepetors. Symptoms of CNS: Anxiety Agitation Insomnia Symptoms of PNS: Tachycardia Hypertension Cardiac Arrhythmias Gastrointestinal Disturbances Brought on by 500 - 1000mg or roughly 5-10 cups of coffee Most doctors suggest imbibing no more that 3-5 cups per day: For those of you that have forgotten, a cup is 8 ounces… A Grande at Starbucks is 16 ounces 2x 16= 32= some hit this point before doc sem Adds up quickly! Caffeine and Alcohol TWINS How does it work? Ellen is Fabulous Other Caffeine Sources

Caffeine presentation

Transcript: Caffeine Other names for caffeine Other names for caffeine - joe -dirt -mud - joe -dirt -mud stimulant Drug Classification Drug Classification Caffeine can look like many different things. It can look like coffee, tea, choclate,etc. What it looks like What it looks like How it enters your system you can either eat it or drink it How it enters your system Short term effects of caffeine Short term effects of caffeine 1. Increased blood pressure 1. Increased blood pressure 2. improved performance in athletics 2. improved performance in athletics 3. flight or fight response is provoked 3. flight or fight response is provoked 4.alertness and energy levels go up 4.alertness and energy levels go up 5.adds muscular endurance 5.adds muscular endurance Long term effects of caffeine Long term effects of caffeine 1. Insomnia 1. Insomnia 2. Nervousness 2. Nervousness 3. Restlessness 3. Restlessness 4. stomach irritation 4. stomach irritation 5.respiration 5.respiration signs and symptoms of addiction signs and symptoms of addiction depressed mood, headaches, muscle pain, stiffness depressed mood, headaches, muscle pa... withdrawl effects of caffeine withdrawl effects of caffeine Nausea, vommiting, lethargy Nausea, vommiting, lethargy anyone can have caffeine in moderation laws about caffeine laws about caffeine ht tps:// 1-866-638-3916 Treatment Options and Hotlines Treatment Options and Hotlines 1. some people are highly sensitive to the effects of caffeine 2. Diet pepsi max has the most caffeine out of all soft drinks 3.400 mg of caffeine is a healthy amount per day 4.caffeine is found in more than 60 plants Other Facts Other Facts

Caffeine Presentation

Transcript: Is Caffeine a Drug? Is it addictive? The effects of caffeine does not fit the definition of an addiction as there is no strong and harmful need to regularly have caffeine in most consumers. Can you overdose or be abused by this drug? Yes you can overdose from consuming a lot of caffeine. A healthy adult should only consume up to 400 milligrams a day. *Although some of these benefits are attributable partially to other substances in coffee, most are attributable to caffeine. Usually: Black tea caffeine > black coffee caffeine Diet coke caffeine > regular coke caffeine Black Tea: 47 mg per 8 oz Black coffee: 95 mg per 8 oz Diet Coke: 45 mg per 12 oz Classic Coke: 34 mg per 12 oz Caffeine affects the Circulatory system if consumed a lot of caffeine you can die. The end! Caffeine Is it healthful? 80 percent less likely to develop Parkinson’s disease Reduced risk of colon cancer by 20 percent. 80 percent drop in the odds of developing cirrhosis. Cut the risk of developing gallstones in half. Helps treat asthma Helps prevent cavities. Helps prevent Alzheimers 53 percent lower risk of dying of heart disease than those who never took a sip Elevates mood Improves alertness Increases problem solving ability Caffeine is classified as a stimulant drug because it raises levels of physiological activity in the body In most people, the benefits outweigh the detriments. For all: Drug classification Coffee Red Bull Monster Rockstar 5 Hour Energy Nos Tea Pepsi Benefits Raises blood pressure if you have hypertension Increases risk of of gout flare up Women are 70% more likely to develop incontinence Can hurt fetus during pregnancy Withdrawal after excessive use: How does caffeine affect the body? Nausea Vomiting By: Joseph Valencia & Zach Miller Street names for Caffeine... Detriments Super Fun Facts: Dehydration* Increased chance of diabetes Indigestion Headaches Caffeine isn't classified as an illegal drug because it is by almost everyone in the United States. Result: What foods/drinks/products contain caffeine? What part of the body does Caffeine affect? Nerve cells confuse caffeine for adenosine and bind it to adenosine receptors. Instead of slowing down the cell, it speeds it up. Specific people: Pepsi Max Diet Pepsi Coca Cola Diet Coke Coke Zero Lime Coke Diet Lime Coke Mello Yello

Caffeine Presentation

Transcript: Cons A drug made of the same materials as caffeine... N The question many seem to pose is whether Caffeine is adicitive. So, to answer the question which raged on since 1820, the answer is yes. Why? While you may not be addicted right now, if you take too much Red Bull (5 cans), or a lot of Coca-Cola (unknown), you can get addicted, ergo, proving that over time, with many of its effects, you will be able, eventually causing death, due to overdose. So, while there are positives to caffeine, at the same time, there are a lot of negatives, so remember, be wise to your caffeine! Error 000: The requested information does not exist. Please try again. Helps energize humans Acts as a natural pesticide for insects Comes in various forms, like coffee, to Cola Wards off drowsiness, and is a stimulant Moderate consumption can actually increase alertness. Effects do not last forever. Really, they don't. Energy Drinks may reduce sleep times, meaning that those that are tired may not sleep, and be addicted to caffeine. It coulld kill animals, from dogs, to horses, and parrots If you overdose on caffeine, you could have a lot of medical problems, from frequrent urination, to liver disease, anxiety, ringing ears, and sensitivity to touch, or pain Extreme overdose could result in anyone ceasing to be, with the lethal dose in rats at 192 milligrams per kilogram. Some people may clench until they have caffeine into their system. Caffeine MAY be addictive. Coffee Cup of Joe Soda Red Bull Caffeine Tea Pros (not a real drink) Caffine is a substance that is bitter to the Human taste Scientists isolated Caffeine from Coffee in 1820, in France. One of the Scientists, Pelliter coined the term, caffeine. Found in varying quantities of food and seeds Acts as a natural pesticide for some insects It is a stimulant, meaning it energizes you What it is Pros and Cons Caffeine 101 Caffeine 101 Source CH3 By Odin Swidzinski Fairhaven's Kim Jong-il Expert CH3 Is Caffeine Adictive? H3C The main sources I got my news and report from is Wikipedia, from the article of caffine, as well as my own knowledge. Now, who wants to discuss about the topic of caffeine? O Coca-Cola Pepsi Cola Coke Cocoa Leaves Et cetera... O N Common Names N Caffine in Drinks Chemical Structure of Caffeine N Coffee Coca-Cola Pepsi Diet Coca-Cola Tea Doctor Pepper Red Bull Mixed Coffee (GDR) Cocoa Leaves Cocaine

Caffeine Presentation

Transcript: Whats In Our Cup? Dental Caries Caffeine As a Professional: Rank from highest amount of caffeine (mg) to lowest: 8oz of: Instant Coffee Starbucks Chai Tea latte AMP Coke Diet Coke Pepsi Starbucks Grande Coffee Full Throttle Sunkist Orange Soda Rockstar Energy drink High Caffeine Consumption TRIVIA 1. Starbucks Grande Coffee 160mg/8oz 2. Rockstar Energy Drink 80mg/8oz 3. Full Throtle Energy Drink 72mg/8oz 4. AMP Energy Drink 71.5mg/8oz 5. Instant Coffee 62 mg/8oz 6. Starbucks Chai Tea Latte 50mg/8oz 7. Diet Coke 31.33mg/8oz 8. Sunkist Orange Soda 27.3mg/8oz 9. Pepsi 25.33mg/8oz 10. Coke 23.33mg/8oz 1. Trivia 2. The Caffeine Kick 3. What Are You Drinking? 4. Caffeine Fix 5. The BIG Picture 6. As an RD Average consumption 70mg/day Main sources: Soda and energy drinks. Stronger Negative effect Peer Pressure Cynthia L. Ogden, Brian K. Kit, Margaret D. Carroll, Sohyun Park. Consumption of sugar drinks in the United States, 2005-2008. NCHS Data Brief. 2011.Accessed July 18, 2013. Rhonda S. Sbasatian, Joseph D. Goldman, Cecilia Wilkinson, Randy P LaComb. Fluid milk consumption in the United States. NHANES Food Surveys Research Group Dietary Info Brief. No. 3. 2010. Accessed July 18, 2013. Jennifer L. Temple. Caffeine use in children: what we know, what we have to learn, and why we should worry. Neurosci Biobehav Rev. 2009; 793-806. Available at NIH Public Access. Accessed July 19, 2013. Michael Moss. Salt Sugar Fat. New York, NY: Random House; 2013. Caffeine consumption - sources, time of day, association with foods Replacing nutritious choices Taste preference and reason for consumption Ethnicity or income contributes to diet The Caffeine Fix Sleep & Development Disruption Children/ Teens Obesity What Are You Drinking? 1. What is the average adult intake (mg) of caffeine per day? 2. What is the average children/teen intake (mg) of caffeine per day? 3. What is the concern of consuming caffeine? 4. Why do people consume caffeine? Adults 90% consume caffeine regularly Main sources: coffee, soda, and tea Less negative side effects The BIG Picture Consume 70mg/day; used to be 38mg/day. There is no known safe amount of caffeine for kids. Stronger effect of caffeine on function, and more likely to experience the negative effects. i.e. nervous, jitters, headache, nausea. More likely to consume soda and energy drinks because they are advertised to this age group. Can be peer pressured into consuming these beverages . The Caffeine Kick There are three main concerns References

Caffeine Presentation

Transcript: Psychological Dependence: People believe that they need caffeine to get going in the morning and can't function without it. Description Immediate Effects of Caffeine Long Term Effects You can't buy happiness but you can buy coffee and that's pretty close Medical term: 1,3,7 trimethylxanthine Slang terms: java, joe, mud, go, caffeine fix, go juice Works Cited Physical Effects: Dehydration which saps energy, heart damage due to rapid beating, Insomnia, and higher blood pressure. Meredith Blackburn, Sage Daughton, Brett Farruggia Caffeine Dangers of Caffeine Mental Effects: Can lead to long term anxiety, and depression due to mood swings. More than 4 cups of coffee a day linked to early death May raise blood pressure Increased risk of heart attacks Caffeine linked to gout attacks Caffeine may cause insomnia Slang Terms Physical Dependence: Physical addiction to caffeine can lead to mild withdrawal such as headaches caffeine occurs naturally in over 60 plants, such as the kola nuts, tea leaves and coffee beans synthetic caffeine can be added to medicines, foods and drinks worldwide, 90% of people consume caffeine in some form the average adult intakes 200 mg of caffeine a day-equal to 4 sodas 70 tablets of Caffeine+L-Theanine costs $11.88 one K-cup costs $0.69 one Starbucks cup of coffee costs $1.45 Physical: Increased Blood pressure, mild diuretic effects, heart rate increases, blood vessels dilate Mental: Alertness Thoughts & Ideas

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