Capnography
Transcript: Emergency Medical Services Capnography Airway Anatomy & Physiology Airway, Ventilation and Oxygenation Anatomy is reviewed to refresh on the structures involved with airway management Ventilation will review the mechanical process of ventilation Oxygenation will review the physiology of external respiration, oxygen transport, cellular metabolism, the blood buffer system, and carbon dioxide expulsion Subtopic Anatomy Review Title Ventilation Medina B. Brenda's A&P eportfolio: objective 48 & 49: inhalation and exhalation [Online]. 2011 [accessed 2012 Dec 11]. Available from URL: http://blm1128.blogspot.co.uk/2011/04/objective-49-contrast-inspiration-and.html. Oxygenation Oxygenation https://www.thinglink.com/scene/701078083121184768 Inhalation & Exhalation External Respiration External Respiration Diatomic molecule Essential to life Effects on the body Permits cellular respiration to occur Vasoconstrictor Can cause the development of free radicals Air: 20.9% O2 Oxygen Diffusion of O2 across the alveolar membrane and binding of O2 to RBCs Caused by a pressure gradient Possible causes for impairment (V/Q mismatch) Obstruction Pulmonary edema Pneumonia Atelectasis COPD External Respiration Partial Pressure: The pressure exerted by a gas, at a given temperature and volume, on its environment. Dalton's Law: The total pressure of a gas mixture is the sum of the partial pressures of that mixture. Henry’s Law: The amount of a gas that dissolves in a liquid is directly proportional to the pressure of the gas above it. Partial Pressure & Gas Laws V = Ventilation, Q = Perfusion Expressed in a ratio 1L of blood can carry ~200mL O2 ; 1L atmospheric air ~200mL O2 V/Q mismatch occurs which the volumes do not appropriately correlate Problem with the synchronization of gas exchange Low V/Q: pathology that is preventing the proper amount of O2 from entering into the lungs for diffusion High V/Q: pathology that is blocking complete blood flow to alveoli V/Q Mismatch Oxygenation Defines how O2 hemoglobin saturation levels are maintained or increased Four binding sites per hemoglobin, each RBC has multiple hemoglobin proteins 5-6L of blood in an adult (24,860,000,000,000 RBCs) SPO2 values determined by calculating percentage of fully bound hemoglobin that pass by SPO2 sensor area Uses red and infrared light and sensor Does not detect unbound oxygen (oxygen dissolved in the plasma) A simple SPO2 sensor will also read bound CO as O2 Not affected by volume of blood Does not provide any information to perfusion status or metabolic status. Only that O2 is (or is not) bound to hemoglobin. Oxygenation SPO2 Pleth https://www.amperordirect.com/mm5/website_v3/products/medchoice/plethgraph.jpg Oxyhemoglobin Disassociation Curve Oxygen less readily binds to hemoglobin, but more readily releases O2 in a rightward shift. Oxygen more readily binds to hemoglobin, but less readily releases O2 in a leftward shift. Factors that drive the curve to the right: lowered pH (including higher CO2), increased temp, exercise. Factors that drive the curve to the left: increased pH (including decreased temp), decreased temp. Oxyhemoglobin Disassociation Curve Oxygenation Requires good blood flow and adequate perfusion pressures throughout the body Pathologies that inhibit oxygen binding, blood flow, or adequate perfusion pressures Hemorrhage All types of Shock Reduced CO PE / DVT Blood agents Acidosis Can be affected by other diseases Sickle cell anemia Hypoxemia: Low concentration of Oxygen in the blood Hypoxia: Deficiency in the amount of oxygen reaching the tissues Hypoxic Hypoxia Caused by a problem with ventilation or external respiration Hypemic Hypoxia Caused by a problem with the carrying capacity of hemoglobin Stagnant Hypoxia Caused by a pathophysiology that causes relative stagnation of blood Histotoxic Hypoxia Caused by interference with internal respiration Hypoxia Internal Respiration Once RBCs make it to capillaries, it is unbound from hemoglobin and becomes dissolved in the blood, eventually making its way to the tissues Krebs Cycle O2 + Other Inputs -> Outputs + Energy + CO2 CO2 is ALWAYS produced by cells that are undergoing metabolism Aerobic Metabolism Anaerobic Metabolism The CO2 moves from the cell back into the blood stream Internal Respiration By Narayanese, WikiUserPedia, YassineMrabet, TotoBaggins - http://biocyc.org/META/NEW-IMAGE?type=PATHWAY&object=TCA. Image adapted from :Image:Citric acid cycle noi.svg (uploaded to Commons by wadester16), CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=6217701 Caused by an overabundance of oxygen molecules within the body, among other natural processes Can be produced by too many oxygen molecules within the electron transport chain and not enough antioxidants Produces an oxygen ion, and a free electron, both of which can cause cellular damage and damage DNA Free Radicals / Oxygen Toxicity Blood Buffer System pH: The measure of free hydrogen ions in a solution 1 7 14 Acidic [H+] Body