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Transcript of Regenerative Medicine
5th Hour History of Regenerative medicine 3 Categories of Regenerative Medicine 1 2 3 direct injection of bolus cells implantation of a 3-d cell grown tissue organ stucture Induction of regeneration using growth factors Cell Therapy Tissue Engineering Growth Factor Delivery Based Tissue Engineering Nose Transplants 1000 b.c Tooth Transplants Mid-1770's Skin Grafts 1800's Rose Granville Harrison grew frog neural tissue in a dish 1907 Kidney Transplants 1950's First Human Lung Transplant 1963 First Human-to-Human Heart Transplant 1967 First genetically engineered cells introduced to patients late 1980's 3 Categories Applications Until it was found to cause syphyllis and tuberculosis Winston Churchill donated skin to a soldier in 1898 a cadaver kidney was successfully transplanted into a human in 1962 Bone Marrow Transplants 1960's Stem Cells : cells with extensive renewal capacity and the ability to generate daughter cells that undergo further differntiation. Adult
Embryonic Cell Therapy is the introdution of new cells into damaged tissue in order to treat disease or injury Stem cells can differentiate across all three germ layers Cells are used as building blocks, and scaffolds made with biomaterials serve as blueprints Requirements for scaffolds high porosity
adequate pore size
Most commonly used synthetic material is polylactic acid however many scaffolds incorporate ECM derivatives cancer
lab grown meat
spinal cord injury