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wound healing & repair

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by

mohammed rasmi

on 4 February 2014

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Transcript of wound healing & repair

Objectives
1. Classify the cells of the body in relation to their ability to replicate with examples.

2. Define terms like healing, regeneration, repair, scarring .

3. Explain the importance of an intact connective tissue framework in the process of regeneration and in determining whether there will be scarring or not.

4. Define granulation tissue and mention the gross and microscopic appearance of granulation tissue.

Cellular Proliferation
Cells of the body are divided into three groups:

• Labile cells
•Stable cells
•Permanent cells
•Cells are continuously proliferating
•Can easily regenerate after injury
•Contain a pool of
stem cells
•Examples:
bone marrow, skin, GIT epithelium
Stable Cells
•Examples:
liver, kidney, pancreas
Cell of theses tissues is quiescent and have poorly replicate activity in their normal state.However, these cells are capable to proliferating in response to injury or loss of tissue mass.
Cells have
limited ability
to proliferate
Limited ability
to regenerate (except liver!)

Permanent Cells
•Examples:

neurons, cardiac muscle
•Cells
can’t
proliferate

Can’t
regenerate (so injury always leads to scar)
Labile cells
Pancreas , Classified into which types of cells
Stable cell
Definition of terms
Healing & Repair :

the process of returning to health; the restoration of structure and function of injured or diseased tissues. The healing processes include
blood clotting
, tissue mending "
regeneration
" ,
scarring
, and
bone healing
.
Regeneration :

the process of complete repair, reproduction, or replacement of lost or injured cells, tissues, or organs
(
without scar formation
)
Scarring ( fibrosis ) :
It is mass of collagen that replaces the necrotic cells when there is failure of resolution or regeneration.

granulation tissues > fibrous tissue > scars
Keloid

is result of
excessive
accumulation of collagen

Healing & Repair
Regeneration
Scarring
Labile cells
Permanent cells
Stable cells
if the cardiac muscles are injured , in which process they can repaired
by fibrosis ( formation of scar )
*The Importance Of An Intact Connective Tissue Framework
In The Process Of Regeneration And Determining
Whether There Will Be Scarring Or Not.

intact tissue framework like in :
Superficial wounds
&
Some inflammatory processes
.
- they lead to regeneration (Restitution of normal structure)
- Examples :-
A) liver regeneration after partial hepatectomy B) resorption of exudate in labour C) pneumonia
Damaged tissue framework like in :
Deep wounds
or if
non-dividing cell are injured

Its lead to healing by Scar formation

Examples :-
A) Deep lacerated wounds B) Myocardium infarction
In which process the superficial skin wound , will be repaired
By regeneration
Definition granulation tissue
* Granulation tissues
is highly vascular, newly formed connective tissues consisting of capillaries and fibroblast; it fills defects created by liquefaction of cellular debris.
It consists of
fibroblasts
surrounded by
abundant extracellular matrix (collagen )
, newly formed
blood vessels ( capillaries )
, and
scattered macrophages ( leukocytes )
and some other
inflammatory cells.
Gross ( clinical )

appearance of granulation tissue
The term granulation tissue derives from its pink, soft, granular appearance on the surface of wounds
numerous blood vessels , inflammatory cells , fibroblast , collagen and loose tissue
microscopic
appearance of granulation tissue
List the composition of granulation tissue
Fibroblast , collagen , new blood vessels , macrophages and some inflammatory cells
Summary
* Types of cells according on the ability to dividing :
1-Labile cells
2-Stable cells
3-Permanent Cells
* Two processes of healing ( repair ) :
1- Regeneration
2- Scarring
* Granulation tissues
is highly vascular, newly formed connective tissues consisting of capillaries and fibroblast; it fills defects created by liquefaction of cellular debris.

The term granulation tissue derives from its pink, soft, granular appearance on the surface of wounds. Also , Proliferation of new small blood vessels and fibroblasts are its histological features.

References :
Done By : Mohammed Rasmi
WWW.MEDSCAPE.COM
Principle of Diseases Block
2nd Seminar

Wound Healing and Repair
Name : Mohammed Rasmi Almutairi
ID : 331100222

My Adviser : Dr.Mostafa Khodeir
Full transcript