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Nursing management of patients taking Alkylating agents

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Jennifer Vinas

on 2 May 2014

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Transcript of Nursing management of patients taking Alkylating agents

Thank You!
Alkylating Agents
Case Study
Mrs. D., a 48-year-old married mother of two teenaged daughters, has been diagnosed with breast cancer. She has undergone lumpectomy to remove the tumor and is about to start adjuvant chemotherapy. She states that she has “faced the facts” about her disease and the threat to her life but says, “I know this is silly, but I hate the thought of losing my hair to this disease.”
1. What measures can be taken to help her deal with her hair loss?

Why and How It Hair Loss Happens
Chemotherapy destroys hair cells, resulting in hair loss
Timing, amount, and type of drug therapy affect hair loss
Chemotherapy Drugs:
Adriamycin: causes complete hair loss on the head
Methotrexate: thins hair in some patients
Ctyoxan and 5-fluorouracil: minimal hair loss in most women
Taxol: complete hair loss (head, brows, lashes, etc.)
Radiation and Hormonal Treatments can also affect hair loss
2. Ten days after the chemotherapy, her neutrophil count drops to 2000 cells/mm3. She has been hospitalized because she has developed a cough, and several of her friends have come in to visit her. What actions should be taken to protect her from infection?
-Neutrophils are fast acting(innate immunity); They are the first line of defense in fighting bacterial infection.
-limit visitation time
-Have vistors wash their hands before entering the room
-Patient will wear a mask
-Give patient some form of zinc; helps with the development of neutrophils and blocks receptors for viruses
3. During rounds, the nurse finds Mrs. D. curled up in the bed and sobbing. Mrs. D. says that she feels “so afraid” and is worried about who will care for her family if she dies. What should the nurse do?
Therapeutic communication
Clinical Psychiatrist
Support Groups
Religious/Spiritual beliefs
Advance Directive Discussion
Facing Chemotherapy
Jessica Lopez
Joynali Nguyen
Victor Pineyra
Nicole Santos
Allyson Uy
Jennifer Vinas

Nursing management of patients taking Alkylating agents
Function: changes shape of DNA double helix and prevents the nucleic acid from completing normal cell division
Induce cell death/ slow replication of tumor cells
# of erythrocytes, leukocytes, and platelets decline
GI problems: nausea, vomiting, and diarrhea
Alopecia may occur
Forming bonds or linkages with DNA
Cold caps
Rogaine (minoxidil)
Preparing family members for the change
Adams,M, Holland, Adams,M., Holland,N., & Urban, C. (2014) Pharmacology for
nurses: A pathophysiological approach (4th ed) New Jersey: Pearson Education.
IBSN: 13: 978-0-13-302618-4
Full transcript