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Copy of Phytochemical Production of metal nanoparticles

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on 15 February 2013

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Transcript of Copy of Phytochemical Production of metal nanoparticles

Methodology - Screening Phytochemical Production of
Metal Oxide Nanoparticles Syed Shah Areeb Hussain - 0824507
Coordinator - Assoc. Prof. Dr. Ibrahim Ali Noorbatcha
Co. Coordinator - Assoc. Prof. Dr. Parveen Jamal Problem Statement Conventional synthesis methods are costly, complicated, toxic and not scalable
Heavy metals used raises environmental concerns
Cannot be used for biomedical applications (toxic impurities) Questions to be Answered? What plant extracts contain the necessary phytochemicals and ability to reduce metal salts to oxide nanoparticles?
What is the size and shape of the nanoparticles produced and conditions that effect size and shape
How can the synthesis process be optimized for large scale?
What are the possible applications of the nanoparticle produced? Scope Literature Review Nanoparticles ~Size : 1 – 100 nm
~Properties:
Small size
- High rate of diffusion
- Metals: Size quantization
- Optical properties
Large Surface Area/Volume ratio
- Stronger nanocomposites
- More interactions - form suspensions ZnO In2O3 Au/Ag Fe3O4 ALOE VERA NEEM Au/Ag Bimetallic
NP SOYA BEAN SPROUTS TiO2 NYCTANTHES ARBOR TRISTIS FALSE DAISY ZnO CHINESE LANTERN SEDUM ALFREDII What has been done What we have done Goethe Soya Bean
Sprouts Dill Aloe Vera ZnO ZnO Fe2O3 ZnO Fe2O3 Fe2O3 MnO MnO MnO MnO TiO2 TiO2 TiO2 TiO2 SiO2 SiO2 SiO2 SiO2 Preliminary
Detection UV-vis
Spectroscopy Color
Change Characterization Methodology Benefit of Study Titanium Dioxide, Zinc Oxide - Sunscreens
Magnetic Nanoparticles - MRI Contrast agents
Data storage
Immuno assays , Targetted drug delivery
Biosensors Titanium Dioxide Nanoparticles - photocatalysts

Generate electricity when exposed to sunlight Nokia - developed concept transparent phone Under influence of light - transparent and generates electricity

When subjected to electricity - nanoparticles blacken - general characteristics of LCD screen Can also be used to make solar cell paints Magnetic nanoparticles - New drug delivery system

Photodynamic drug encapsulated in nanocarriers with iron oxide nanoparticles

Efficient uptake of nanocarriers by cells in area exposed to magnetic field

Reduce drug accumilation in normal tissue - less side effects Transmission Electron
Microscopy Feild Emission Scanning Electron Microscope Scanning Electron
Microscopy Physical
Methods Chemical
Methods Biological
Methods Micro-
organisms Enzymes Plant Extract Laser
Ablation Flame
Pyrolysis Inert-gas
Condensation Sol-Gel Solvothermal
Synthesis Chemical
Reduction Synthesis Chemical Methods - Toxic, Environmental Issues, expensive

Biological Method - Eco friendly, facile, cheap, simple Use suitable plant extract ans salt solution to produce nanoparticles and characterize them
Propose the methodology for producing the specified nanoparticle
Optimize the process
Explore potential applications
Limitation : Mechanism of production of np will not be studied THANK YOU!!!
Questions? Objectives Screening Optimization Charact-
erization 70 gm leaves - Washed
- Finely Cut Boiled at 100 C - 15 min Ground with mortar pestle Thick paste 200 ml Distilled Water + Filter Preparation of Plant Extract Addition of Salt 5 ml Plant Extract Observed every 1 hour for 24 hours Heated - 60 C 0.1 M Salt Solution - 5 ml Vigorous Stirring Sample removed from hot plate + + 5 minutes Methodology - Optimization Zinc oxide nanoparticle from Zinc Nitrate 2 Extracts Boiled- 30 minutes Grind to thin paste Filter Preparation of Plant Extract 50 g Aloe Vera Leaf
Cut and boil - 30 min Scoop gel from leaves Filter Blender - Thin Paste Addition of Salt Heat - 150 C
+
Vigorous Stirring Oven Dry - 60 C Cool at room Temperature 50 ml extract + 30 g Zinc Nitrate Wash with distilled water
+
Centrifuge - 4500 rpm, 15 min Constant Stirring 2 hours Results Screening Kalanchoe Pinnata (Goethe Plant) No result No result No result No result No result No result No result Color Change Uv- vis Spectroscopy No nanoparticles - Sample has same peak as extract No result No result No result No result No result No result With zinc Acetate With Tetraethyl orthosilicate With Manganese Acetate With Iron Acetyl Acetonate With Manganese Acetate With Tetraethyl Orhtsilicate With Zinc Nitrate With Zinc Acetate Dill Soya Bean Sprouts With Zinc Acetate With Zinc Nitrate With Tetraethyl Orthosilicate With Manganese Acetate With Manganese Acetate With tetraethyl Orthosilicate Optimization Leaf Extract Characterization (a) 10% (b) 20 % (c) 30 % (d) 40 % (e) 50% concentration Characterization (a) 10% (b) 20 % (c) 30 % (d) 40 % (e) 50% concentration Optimization Gel Extract Conclusion No nanoparticles obtained in the screening processes - possible cause - extract preparation process

Zinc oxide nanoparticle synthesis using from previous study shows increased yield at lower concentrations.

Agglomeration observed possibly due to inadequate stirring

Possibility of zinc oxide nanorods being formed. Observed peak - 300 nm
Actual peak - 540 nm UV- vis results Observed Peak - 360 nm Aloe Vera THANK YOU!!!
Questions? Obtained From
Mainsiri et al.,(2008) Obtained From
Sangeetha & Sivaraj (2001) (Smijs & Pavel, 2011) (Weinstein et al., 2011) (Dobson, 2006) References Dobson, J. (2006). Magnetic nanoparticles for drug Delivery. Drug Development Research, 55-60.

Mainsiri, P. L., Klinkaewnarong, S. P., Promarak, V., & Seraphin, S. (2008). Indium oxide (In 2 O 3 ) nanoparticles using Aloe vera plant extract: Synthesis and optical properties. Journal of Optoelectronics and advanced materials , 161-165.

Sangeetha, G., & Sivaraj, R. (2011). Green synthesis of zinc oxide nanoparticles by aloebarbadensis miller leaf extract. Materials Research Bulletib, 46 (12):2560-2566

Smijs, T., & Pavel, S. (2011). Titanium dioxide and Zinc oxide nanoparticles in sunscreens: focus on their safety and effectiveness. Nanotechnology, Science and Applications, 95

Weinstein, J., Vaallyay, C., Dosa, E., Gahramanov, S., Hamilton, B., Rooney, W., Neuwelt.(2010). Superparamagnetic iron oxide nanoparticles: diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and central nervous ystem inflammatory pathologies. Journal of Cerebral Blood flow Metabolism, 15-35
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