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Synthetic neurobiology

CCST9001 final poster
by

Wenqi Pan

on 25 April 2012

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Transcript of Synthetic neurobiology

Synthetic Neurobiology
Eva, Shannon, Michael
Apr. 25, 2012

Before

the

story starts
Synthetic Biology
NEURO ?
Reference&Image Source
What happens ?
Ed Boyden
What did they do ?
Non-invasive
control device
Optogenetics
Aim:
Apply light to activate or repress specific neurons in order to study the brain neural circuits.
Method:
Synthetic Biology
Principles:
Eyespot
Green algea
Channelrhodopsin
Dark condition
Exposed to
blue
light
Light induced charged ions cross-membrane transportation
Light electricity
Extracts the channelrhodopsin gene
transplant the gene into the neural cells
channelrhodopsins embeded in the membrane of specific neurons
Conclusion
Merits
Improvement in:
Neuroscience
Brain Understanding
Mental Health
Population Quality
Philosophy
Demerits
Public Concerns on:
Biosafety
Mind Control
Demonstration
Fear for
Mind Control
Religious Problems
Enhance Brain Functions
Treat Insomnia
Ease Anxiety
Improve Memory
Increase IQ
Talking Tom Cat
Reversal Analysis on the Brain
Developed a protein sending signals out according to the brain activities
Decoded thoughts in brain by analyzing the signals
Talking Tom Cat in Real Life
Able to know others’ thoughts
2060...
Personality Improvement
Memory Control
Stabilize/treat
Brain Disorders
Alzheimer's disease
2013
2020
2008
2030
2037
2045
Parkinson's disease
Huntington's disease
Multiple sclerosis
Cerebral palsy
这里再帮着加点内容啦。。。唔该 Mind Control
More
CRAZY
ideas...
Dream Invasion
.
.
.
Turn nueron
on
as you wish!
Optical fibres
Time Travel Starts !
Control device
Precise light control device
2012
Protein Hunting
halorhopsin

archaerhodopsin

...
2018
Identify functions of different neurons
Sensations
Feelings
Decisions
Actions
Cure Blindness
The
blind
mice can see !
retinitis pigmentosa
macular degeneration
Photoreceptor cells
Channelrhodopsins
ARCHAEA
Magnetotactic Bacteria
magnetite tight-binding
protein
Wireless Control
To be countinued...
Synthetic neurobiology
Q&A
epilepsy
2060
(Remember Inception?)
2020
Can we fix the circuit computations that have gone wrong?
Start-up Company
novel treatments for blindness
serious neurological conditions optogenetic and gene therapy approaches.
genetically targeted neurotherapeutics
Disorders
High throughput screen
Epilepsy
Parkinson
Schizophrenia
Depression
Addction
...
1. TED Talk. Ed Boyden: A light switch for neurons http://www.ted.com/talks/ed_boyden.html

2. The Birth of Optogenetics. An account of the path to realizing tools for controlling brain circuits with light. By Edward S. Boyden | July 1, 2011 http://the-scientist.com/2011/07/01/the-birth-of-optogenetics/

3. Synthetic neurobiology group. Ed Boyden, Ph.D., Principal Investigator http://syntheticneurobiology.org/

4. iGEM Toolkits: Magnetosomes http://2011.igem.org/Team:Washington/Magnetosomes/Magnet_Toolkit

5. Optomagnetic Design. NYMU TaiWan. University of Washington http://2011.igem.org/Team:NYMU-Taipei
Full transcript