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DNA

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by

Danilo Corleone

on 24 April 2015

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Transcript of DNA

DNA DISCOVERY
LIKE A PUZZLE


1950
Revolution in molecular biology
CRICK - WATSON - WILKINS - FRANKLIN
INSIGHT
INNOVATION
PERSISTANCE

HOW DO LIVING THING PASS ON TRAITS TO THEIR OFFSPRING?
NEW FINDINGS
DON'T COME OUT
OF NOWHERE
GREGOR MENDEL
DNA AND PROTEINS
FIRST ONE
HOW COULD DNA CARRY ALL THE INFORMATION NEEDED TO MAKE A NEW ORGANISM?
MOLECULAR COMPONENTS OF DNA
THE SECOND PIECE
THE THIRD PIECE THANKS TO WILLIAM ASTBURY
CHARGAFF GAVE ANOTHER PIECE
THE PUZZLE SO FAR
Maurice Wilkins
RAYMOND GOSLING, A Ph.D. STUDENT IN WILKIN'S LAB
CONFERENCE
SAMPLE DNA
NEW OBSERVATIONAL TECNIQUE CALLED X-RAY DIFFRACTION
WORKING BACKWARD FROM X-RAY DIFFRACTION PATTERNS TO RECONSTRUCT THE THREE-DIMENSIONAL STRUCTURE THAT PRODUCED THE SCATTERING
DNA DID HAVE
A REGULAR STRUCTURE
DNA MIGHT COME IN THE FORM OF A TWISTED SPIRAL
1951
WILKINS PRESENTED THE RESULTS AT A CONFERENCE IN ITALY
JAMES WATSON
FRANCIS CRICK
FIGURE OUT WHAT THE DNA STRUCTURE WAS
ROSALIND FRANKLIN BEGAN WORKING WITH GOSLING
THE DRY A FORM
HELD LESS WATER
IN THE WET B FORM WATER
MOLECULES CLING TO THE DNA
CAUSING IT TO STRECH OUT
ANOTHER PIECE
ANOTHER ONES
HYPHOTAHESES
AS
LINUS PAULING
WATSON WENT TO A FRANKLIN'S CONFERENCE TO OBTAIN MORE DATES
WATSON AND CRICK BUILT THEIR FIRST MODEL, BUT SOMETHING WAS WRONG...
MEANWHILE WATSON AND CRICK WERE BUILDING THIER MODELS, FRANKLIN WITH GOSLING CONTINUED TO WORK ON DNA BY X-RAY TECHNIQUE...
IMAGE A
IMAGE B 51
CONFIRMATION
AND NEW DISCOVERIES
THE PUZZLE SO FAR
FRANKLIN LEFT THE LAB
GOSLING SOUGHT ADVICE FROM WILKINS
WHO SHOWED THE IMAGE B51 TO WATSON
NEW HYPOTHESIS
TWO PHOSPHATE-SUGAR-BASE CHAINS LINKED TOGETHER
BASES TOWARDS THE CENTER
BUT THEY WEREN'T THE ONLY ONES THINKING ABOUT A DOUBLE HELIX...
AND ROSALIND FRANKLIN WAS THE ONLY WITH ALL THE DATA
WATSON AND CRICK MET SOMEONE AT MRC...
LAST QUESTIONS:
- HOW DID THE BASES FIT TOGETHER?
- HOW COULD THE BASES FIT INSIDE THE CHAINS WITHOUT TOUCHING OR REPELLING?
WATSON HYPOTHESIS: A-A , C-C , G-G, T-T
JERRY DONOHUE
PARTICULAR PLACEMENT OF HYDROGEN ON BASES
WATSON AND CRICK
PUBLISHED THEIR
PROPOSED STRUCTURE
SHARP SCATTER WITH
MANY DISTINCT SPOTS
CLEAR X SHAPE
THE CORRECT FORMS FOR BASES
Corleone Danilo V M 2014-2015
Full transcript