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Innovation in the OR

Timeline
by

Ty Dunn

on 26 January 2014

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Transcript of Innovation in the OR

Innovation in the OR

Pancreas Transplantation

1982
First Pancreas Transplant

Richard Lillehei
& Bill Kelly
1978
Lillelhei Series:
Is correction of the diabetic state required to perform successful kidney transplants?
Iterative Development
The Beginning
Coming of Age
Ty Dunn, MD MS
University of Minnesota

ASTS Winter Meeting
PreMeeting Symposium
Jan 23, 2014

June 29
1966
1966-1973
10 SPK
1 PTA on HD

3 PTA (non uremic)
(uremic)
ONE of 14
achieved 1 year
graft survival
1973
Islets
NONE
achieved
insulin independence
First Pancreas

Retransplant

U of CO - PAK
Cyclosporine A
1980
There's an app for that!
Identical twin series:
Recurrent Type 1 DM
Modern Era
Futurescape
1983
1981
1984
First successful Islet transplant
1990
1991
Tacrolimus
20 cases of
duodenocystostomy
Rob Corry & Dai Nghiem
1985
1987
1976
First
open-duct drainage
Bewick @ Guy's Hospital
Gliedman of
Montefiore

reports 4 cases
of
ureteral
drainage
1971
Lyon Meeting
only 105 transplants done worldwide
First report of the IPTR
10
bladder drained
SPKs
Starzl reintroduces
enteric drainage
1992
Portal Drainage
Rosenlof UVA
Shokou-Amri U Tenn
1979
First
living donor
segmental pancreas
1994
Preservation Solutions:
LR
Collin's
Silica gel filtered plasma
Belzer (UW)
HTK
generics
Gaber in 1992
CT guided pancreas biopsy
Gruessner in 1996
laparoscopic pancreas biopsy
1996
2004
MMF
Valgancyclovir
Spitzingsee Meetings
Allen - Mayo
transcystoscopic
pancreas biopsy
1988
split pancreas technique
Sutherland
Gruessner
Laparoscopic LD kidney & segmental pancreatectomy
2001
1st enteric conversion
Tom @ U Cincinnatti
Use of DCD pancreata among adult recipients
2010
2005
Boggi
retroperitoneal portal enteric
Boggi
robotic pancreas transplant
2003
2006
Rapid Discontinuation of Steroids in pancreas transplantation
Clinical Islet Transplant
Consortium
Miami
UCSF
Minnesota
Edmonton
Penn
Xeno and alloislet
Emory
Karolinska
Uppsala
Wisconsin
Northwestern
Oslo
MGH
U of IL
normothermic preservation?
molecular microscope?
I have no disclosures
PDRI
program builders
if we can diagnose rejection without a biopsy, can we abandon bladder drainage?
if we can avoid ischemia-reperfusion injury, can we further reduce thrombosis and rejection?
Full transcript