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Neutrophils - Lord of innate immunity system


Dominika Ostrowska

on 19 March 2013

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Transcript of Neutrophils - Lord of innate immunity system

Neutrophils - Lord of innate immune system
Dominika Ostrowska Neutrophils:
- the most abundant white blood cells
- key components of the innate immune response Terminally differentiated Short life in circulation The nucleus is split into three to five lobules Alternative name of
“polymorphonuclear” Granules specialized vesicles with a specific load Classified into :
gelatinase Neutrophils are released from the bone marrow These release is tightly regulated in healthy individuals Chemokines control the passage PMNs into circulation and maintain a pool of cells ready in case of infection Neutrophil activation This is process of transition, during which the neutrophil integrates a complex barrage of environmental cues and translates them into specific actions Neutrophil recruitment to sites of inflammation Elimination of microbes Kill microbes Do no harm to the host Neutrophil granules Antimicrobial Proteins Neutrophils produce many proteins and peptides that can kill microbes Reactive Oxygen Species ROS are produced in a process of respiratory burst Phagocytosis Mechanism to remove pathogens Active, receptor- mediated process Particles are internalized by cell membrane Neutrophil Extracellular Traps NETosis - an acitve form of cell death It leads to release of decondensed chromatin into extracellular space Respiratory burst is a rapid increase in oxygen consumption upon neutrophil activation NETs contain histones, antimicrobial granular and cytoplasmic proteins NETs trap microbes and kill them Thank you for your attention - Kumar, V., & Sharma, a. (2010). Neutrophils: Cinderella of innate immune system. International immunopharmacology, 10(11), 1325–34. doi:10.1016/j.intimp.2010.08.012
- Amulic, B., Cazalet, C., Hayes, G. L., Metzler, K. D., & Zychlinsky, A. (2012). Neutrophil function: from mechanisms to disease. Annual review of immunology, 30, 459–89. doi:10.1146/annurev-immunol-020711-074942
- Lee, W. L., Harrison, R. E., & Grinstein, S. (2003). Phagocytosis by neutrophils. Microbes and Infection, 5(14), 1299–1306. doi:10.1016/j.micinf.2003.09.014
- Panasiuk, A., Wysocka, J., Maciorkowska, E., Panasiuk, B., Prokopowicz, D., Zak, J., & Radomski, K. (2005). Phagocytic and oxidative burst activity of neutrophils in the end stage of liver cirrhosis. World journal of gastroenterology: WJG, 11(48), 7661–5. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/16437695 ;)
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