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Behandlung von posttraumatische Belastungstorung mit MDMA

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Philip Hartout

on 27 January 2017

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Transcript of Behandlung von posttraumatische Belastungstorung mit MDMA

Was ist posttraumatische Belastungsstörung?
- Verbindung präfrontale Kortex/Amygdala
MDMA als Therapiemöglichkeit für posttraumatische Belastungsstörung
Philip Hartout
Was ist posttraumatische Belastungsstörung?
Krieg

Alptraüme / Halluzinationen

Symptome ω ¬ k. Ursache.
Was ist MDMA?
MDMA = Psychadelika + Stimulans
+ Aktivität Amygdala
- Volumen Hippokampus
psychologische Symptome
Wie kann MDMA posttraumatische Belastungstörung behandeln?
Experiment:
20 traditionele Behandlung-resistente Teilnehmer
Psychotherapie + MDMA
Ergebnisse
4 Jahre
(Oehen et al. 2012)
Was passiert in den Hirnen?
Herstellung der Verbindung pK/A

- Aktivität der Amygdala
Quelle

Carhart-Harris, Robin L., et al. "The effects of acutely administered 3, 4-methylenedioxymethamphetamine on spontaneous brain function in healthy volunteers measured with arterial spin labeling and blood oxygen level–dependent resting state functional connectivity." Biological psychiatry 78.8 (2015): 554-562.

Selvaraj, Sudhakar, et al. "Presynaptic serotoninergic regulation of emotional processing: a multimodal brain imaging study." Biological psychiatry 78.8 (2015): 563-571.

Pitman, Roger K., et al. "Biological studies of post-traumatic stress disorder." Nature Reviews Neuroscience 13.11 (2012): 769-787.

Boccia, Maddalena, et al. "Different neural modifications underpin PTSD after different traumatic events: an fMRI meta-analytic study." Brain imaging and behavior 10.1 (2016): 226-237.

Cook, Fallon, et al. "Changes in long term neural connectivity following psychological trauma." Clinical Neurophysiology 120.2 (2009): 309-314

Oehen, Peter, et al. "A randomized, controlled pilot study of MDMA (±3, 4-Methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD)." Journal of Psychopharmacology (2012): 0269881112464827.
Effekten:
Euphorie ++ Soziale Verhaltung
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