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Doxorubicin presentation

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Samhita Kadiyala

on 14 March 2014

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Transcript of Doxorubicin presentation

"Radiation recall" (can bring back skin damage from previous radiation therapy)
decreased blood cell counts
increased risk of infection and bleeding
loss of appetite
stomatitis
alopecia (hair loss)
Nausea and vomiting
Mouth sores
Birth defects
liver toxicity
acute arrhythmia
darkening of nail beds and skin creases of hands A Chemotherapy Drug Presentation by: Doxorubicin About Cancer and Chemotherapy Chemical Properties of Doxorubicin Medical Properties of Doxorubicin Samhita Kadiyala What is Cancer? Cells grow out of control
Instead of dying, form abnormal cells
DNA damage
Cells invade tissue
Most cancerous cells form tumors
cancer cells get into the body’s bloodstream or lymph vessels.
tumors replace normal tissue. The process of cancer spreading is called metastasis.
Regardless where cancer spreads, named after place of origin What is Chemotherapy? Drugs that interfere with cancer cell's ability to grow or multiply (cancer cells multiply and divide quickly)
DNA-damaging agents. "Alkylating agents", damage the DNA so severely that the cancer cell is killed.
Antitumor antibiotics. Insert themselves into a cancer cell's DNA, prevent the DNA from functioning normally and often kill the cancer cell. (Doxorubicin)
Antimetabolites. Mimic the substances that the cancer cell needs to build DNA and RNA. When the cancer cell uses the antimetabolite instead of the natural substances, it can't produce normal DNA or RNA and the cell dies.
DNA-repair enzyme inhibitors. Repair of DNA damage is a normal and vital process in the cell. Without this repair process, the cancer cell is much more susceptible to damage and is prevented from growing. These agents attack the cancer cell proteins that normally repair DNA damage
Can harm healthy cells that divide quickly as well (mouth, intestine, hair growth cells, bone marrow) 1/2 all men, 1/3 all women have cancer
[American Cancer Society] 3D Chemical Structure Chemical Properties C27H29NO11
General group: Antineoplastics
anticancer drugs
Anthracycline antibiotic
slows or stops growth of cancer cell
Antitumor Antibiotic
Insert themselves into a cancer cell's DNA, prevent the DNA from functioning normally and often kill the cancer cell
Intercalating agent
wedges between the DNA, blocking DNA synthesis and transcription http://screencast.com/t/2puZWoVQX0v Trade names Doxil
Caelyx
Adriamycin
Rubex
Adriablastin What does it treat? Autoimmune deficiency syndrome (AIDS)–associated Kaposi's sarcoma (a type of cancer of the skin and mucous membranes that is more common in patients with AIDS)
Cancer of the adrenal cortex (the outside layer of the adrenal gland)
Cancer of the cervix
Cancer of the endometrium
Cancer of the esophagus
Cancers of the head and neck
Cancer of the liver Cancer of the pancreas
Cancer of the prostate
Cancer of the thymus (a small organ under the breast bone)
Carcinoid tumors
Chronic lymphocytic leukemia (cancer of the blood and lymph system)
Ewing's sarcoma (a type of cancer found in the bone)
Gestational trophoblastic tumors (tumors in the uterus or womb)
Hepatoblastoma (a certain type of liver cancer that occurs in children) What does it treat? Multiple myeloma (a certain type of cancer of the blood)
Non–small cell lung cancer (a certain type of lung cancer usually associated with prior smoking, passive smoking, or radon exposure)
Retinoblastoma (a type of eye cancer found primarily in children)
Tumors in the ovaries How is it given? Intravenous (IV)
15 minute dose
Anti-nausea medicine before and after
Blood count check before and after
comes as a solution (liquid) or as a powder to be mixed with liquid to be injected In a newer formulation, Doxil, the drug is surrounded by a lipid 'bubble' (membrane). This formulation is an attempt to reduce the toxicity of the drug by blocking its effects on normal tissues. Side Effects Chemobrain Cancer treatments such as chemotherapy and radiation therapy can cause problems with cognitive (mental) functions, such as concentration, memory and the ability to multitask. Most chemotherapy patients experience these effects to some degree. The effects are sometimes referred to as chemobrain or brain fog More Chemical Properties Melting Point: 229 - 231 degrees Celcius
pH: 7.3
molecular weight: 579.99
Prices
Doxorubicin 50 mg vial: 132.0 USD
Doxorubicin 10 mg vial: 44.4 USD Cardiomyopathy Cardiomyopathy is a disease that weakens and enlarges the heart muscle. There are three main types of cardiomyopathy — dilated, hypertrophic and restrictive. Cardiomyopathy makes it harder for the heart to pump blood and deliver it to the rest of the body. Cardiomyopathy can lead to heart failure. more than 100 types 1. Don't use tobacco
In 2004, 1.6 million of the 7.4 million cancer deaths were due to tobacco use. [WHO]
2. Eat a healthy diet
3. Maintain a healthy weight and be physically active
4. Protect yourself from the sun
5. Get immunized6. Avoid risky behaviors
7. Get regular medical care Sources 1. http://www.chemspider.com/Chemical-Structure.29400.html?rid=ca1ec72b-9bde-40b3-87f3-5415bf864dc5 (ChemSpider.com - chemical structure and chemical formula)
Usefulness: 8 ; Trustworthiness: 10; database with many trustworthy sources (including journals) Very Balanced POV
2. http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682221.html (MedlinePlus A service of the U.S. National Library of Medicine National Institutes of Health)
Usefulness: 10 ; Trustworthiness: 10; it is a .gov site
3. http://www.cancer.org/treatment/treatmentsandsideeffects/guidetocancerdrugs/doxorubicin (American Cancer Society)
Usefulness: 10 ; Trustworthiness: 10
-Has a hon code

4. http://www.mayoclinic.com/health/drug-information/DR600581 (The Mayo Clinic)
Usefulness: 10 ; Trustworthiness: 10

5. http://www.lls.org/#/diseaseinformation/managingyourcancer/treatmentnextsteps/typesoftreatment/chemotherapyotherdrugtherapies/chemotherapy/ (The Leukemia and Lymphoma Society)
Usefulness: 10 Trustworthiness: 10
-HONcode

6. http://www.cancer.org/cancer/cancerbasics/what-is-cancer (The American Cancer Society)
Usefulness: 9 Trustworthiness: 10

*7. Texas Heart Institute Journal; 2012, Vol. 39 Issue 3, p424-427, 4p, 1 Black and White Photograph, 1 Diagram (Library Source)
Usefulness: 6 Trustworthiness: 10 Hard to understand (many medical terms)

*8. Patrick Burns, Daniel A. Vaena, "Chemotherapy and other antineoplastic drugs," in AccessScience, ©McGraw-Hill Education, LLC, 2012, http://www.accessscience.com.rpa.santaclaracountylib.org (Library Source)
Usefulness: 5 Trustworthiness: 10
Good information, well organized, hard to understand 9.www.fda.gov%252Fohrms%252Fdockets%252Fac%252F99%252Fslides%252F3521S2_01_ALZA.ppt%26ei%3DWvATUdbQHoa5igKz7IEQ%26usg%3DAFQjCNH8PjHgxug47EvX0Trelbjtk225rQ%26sig2%3DXBrnR3CbCQKQ_S9pcWOsIA&ei=WvATUdbQHoa5igKz7IEQ&usg=AFQjCNH8PjHgxug47EvX0Trelbjtk225rQ&sig2=XBrnR3CbCQKQ_S9pcWOsIA
Usefulness: 6 Trustworthiness: 10 Balanced POV, completely factual presentation

10. http://www.doxil.com/ovarian-cancer/about-doxil
Usefulness: 7 Trustworthiness: 8
-Managed by Janssen Biotech, a Branch of Janssen Pharmaceuticals, a branch of Johnsson & Johnsson
-Balanced point of view, listed dangers, warnings and good info.

11. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=31703#x27 National Center for Biotechnology Information
Usefulness: 3 Trustworthiness: 10 (.gov site) Research and factual information; great for in-depth research

12. http://www.drugbank.ca/drugs/DB00997 DrugBank
Usefulness: 9 Trustworthiness:10 (Federal Government sponsored)

13. http://www.netdoctor.co.uk/cancer/medicines/caelyx.html NetDoctor (UK)
Usefulness:9 Trustworthiness: 10 (HonCode)

14. http://chemocare.com/chemotherapy/drug-info/doxorubicin.aspx (The Scott Hamilton CARES Initiative)
Usefulness: 9 Trustworthiness: 6 Not a reliable source; Not very balanced info

15. http://www.cancerquest.org/drugs/doxorubicin.html (CancerQuest)
Usefulness: 8 Trustworthiness: 10
-HONcode
-cancer education and outreach program at Emory University
16. http://www.cancer.gov/cancertopics/cancerlibrary/what-is-cancer (National Cancer Institute)
Usefulness: 9 Trustworthiness: 10
-.gov site
-balanced info and diagrams
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