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Lipidomics

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by

Adina Levi

on 22 January 2014

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Transcript of Lipidomics

Lipidomics
Mass spectrometry is a method that allows for us to observe the many conditions of matter. It allows the viewing of the mass of the particles and molecules, and the chemical structure of molecules. Mass spectrometry measures the molecule’s mass to charge ratios.

Other technologies include nuclear magnetic resonance (NMR) which develops the magnetic properties of atomic nuclei, spectroscopy, which is the interactions between matter and radiated energy, fluorescence spectroscopy, which is analyzing the fluorescence of a material, and dual polarisation interferometry, which measures the change in proteins.
Lipidomics mass spectrometry can be used to reveal lipid changes that occur in metabolic disorders such as diabetes, obesity, hypertension, stroke, and atherosclerosis. It also enables the findings of 3D and time-based changes in lipids that occur with disease development or treatment.
Lipidomics--what is it?
It is the analysis of lipids and their pathways and networks in biological systems
Technologies used in lipidomics:

The QTRAP® 5500 System and other QTRAP® Systems deliver precise lipid measurements. The enhanced speed of the QTRAP® 5500 increases efficiency.

The 4000 QTRAP LC/MS/MS System is a mass spectrometer with a hybrid analyzer.
Lipid changes regulate the membrane structure and function, which causes the function of neurons at the cellular level.
Research Paper: Lipidomic Mass Spectrometry and its Application in Neuroscience (Enriquez-Algeciras)

Lipids are involved in most steps of critical function of nervous systems. Lipids are present in the brain, providing insulation for the transmission of signals that lets neurons stay in their environment. Until recently, lipidomics had two big disadvantages:

1. Hard to identify vast number of lipids
2. The matter had to be extremely pure in order to determine their structures.

These disadvantages have been overcome. Due to the recent advancements in mass spectrometry, it allows a level of straightforwardness while identifying lipids in the neuronal system.

Works Cited:

"CECAD Cologne: Technical Equipment." CECAD Cologne: Technical Equipment. N.p., n.d. Web. 21 Jan. 2014.

Enriquez-Algeciras, Mabel. "Result Filters." National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 21 Jan. 2014.

"Lipidomics Research." AB SCIEX. N.p., n.d. Web. 21 Jan. 2014.

"Lipidomics." Wikipedia. Wikimedia Foundation, 18 Aug. 2013. Web. 20 Jan. 2014.

The TripleTOF® 5600+ System displays accurate mass lipid detailing for lipidomics research at great speeds without compromising resolution or sensitivity. It results in a 3D chart of all lipid fragments.
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