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Biology - Cell Division/Mitosis

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james donahue

on 6 July 2016

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Transcript of Biology - Cell Division/Mitosis

Cell Division
Big Questions:
Make Sure You Can:
Why Divide?
The Cell Cycle
The "continuity of life"
In order to survive, the individual must replace damaged cells.
In order to grow, cell production must be greater than cell death.
In order to survive, the species must replace individuals.
Cell division accomplishes these purposes.
A dividing amoeba
A dividing bone marrow cell
A dividing sea urchin embryo
The phases of a cell's life
G1- growth
S- DNA replication
G2- preparation for division
M - Mitosis

G0- Non-dividing state (most cells in you)
Very tightly controlled (why?)
Tightly coiled pieces of DNA that condense prior to division
Prokaryotes only have one, circular chromosome.

Eukaryotes have many, linear chromosomes
Most eukaryotic cells have 2 copies of every chromosome.

They form in attached, identical pairs.

Chromatid: 1 member of the pair
Centromere: region where they are joined
S phase
Make sure you understand the chromosome, chromatid relationship

It can be confusing...
Haploid vs. Diploid
1 copy of every chromosome (n)
2 copies of every chromosome (2n)
Human cells have 23 pairs of chromosomes

How many chromatids are present during:
Chromosomes Condense
Nuclear envelope breaks down
mitotic spindle begins to form
Animal cells: centrioles divide.
Chromosomes begin to migrate to cell equator.
2 complete spindles at cell poles.
Chromosomes are at metaphase plate.
Spindle attaches to "kinetochore" of chromosomes at centromere
Chromatids split apart at centromere.
Migration of chromatids to cell poles mediated by the kinetochore.
Chromosomes decondense
Nuclear envelope reforms
Cytokinesis: cell membrane divides
Replication of DNA
Preparation for division

Most of a cells life cycle
Newt, Whitefish, Onion
Differences between plant-like and animal-like cells (Why?)
A "contractile ring" of microfillaments pinches the cell in 2
Vessicles from both cells deposit a new cell wall partition ("cell plate") in the middle of the cell.
Organelle apportionment is essentially random.
Mitosis at a Glance
Let's play "spot the phases"
(Xerox copy)
Eukaryotic Cell Division
Describe the roles that mitosis plays in eukaryotic organisms.

Explain how mitosis produces two genetically identical cells

Explain how interphase prepares a cell for mitosis.

Explain why many cells never divide.

Explain the function of each stage of mitosis

Compare the events of mitosis in plant-like and animal-like cells
Why do cells need to divide?

How does cell division provide for continuity of life processes in an individual and in a species?
"Binary Fission"
The splitting of
the cell into two.
DNA - Episode 4: Curing Cancer
So, what is CANCER?
Full transcript