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Thesis Defense Presentation
Transcript of Thesis Defense Presentation
13.2 million by 2050
Almost $200 billion annually
$80,000 per year for caregivers
Amyloid plaques- Beta-amyloid
Neurofibrillary Tangles (NFT)- tau protein
Tau and Tauopathies
Hyperphosphorylated in AD and related tauopathies
Mutations characterize different tauopathies
FTDP17 characterized by R406W mutation
(Morris et al., 2011)
elav-GAL4: neuron-specific driver
UAS-tau: gene of interest
Environmental Enrichment (EE)
Improves learning and memory in a mouse model of AD
Increases mating success in fruit flies
Higher concentration of Mushroom Body fibers in fruit flies
(Jankowski et al., 2005)
(Dukas & Mooers, 2003)
Transgenic Flies are Expressing Tau
Fruit Fly Enrichment
1. Standard Vial Housing
Does EE affect tau toxicity?
Does EE affect tau phosphorylation?
Hypothesis: Environmental Enrichment will ameliorate tau toxicity and phosphorylation in a fly model of tauopathy.
2. Empty Arena:
70x more vol./fly
3. EE Arena:
Visual and tactile stimulation
EE Extends Control and Tau Fly Lifespan
Female Tau and Phosphorylation Levels are Equivalent
Male Tau and Phosphorylation Levels are Elevated
EE extended control and tau fly lifespan
EE ameliorated tau toxicity
EE increased tau phosphorylation in males
Repeat lifespan experiments with separated sexes
Perform tau localization studies in Mushroom bodies
Address the effects of EE on heterochromatin relaxation
Thomas Liimatainen (MHC machinist)
MHC Department of Neuroscience
The fruit flies
May 1, 2014
Investigating the Effects of Environmental Enrichment on a
Model of Tau Toxicity