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Pedro Sanchezon 13 January 2015
Transcript of DNA Detectives
What is a
Small Beaker or cup
Zipper Lock Bag
1 salt pack
KEYS FOR A CAREER in
3C's & 2P's
Did you know that DNA is in
the food you eat? DNA is present in
every cell of all plants and animals and
determines the genetics of the individual
Strawberries are the perfect choice for a DNA extraction lab, because they yield more DNA than any other fruits, and they are octoploid, meaning that they have eight copies of each type of DNA chromosome. These special characteristics make strawberry DNA easy to extract and see.
To extract the DNA, each component plays a part. The soap helps to dissolve the cell membranes. The salt is added to break up protein chains that hold nucleic acids together, releasing the DNA strands. Finally, DNA does not dissolve in isopropyl alcohol. and even less so when
the alcohol is ice cold
Real life applications
- genetic engineering
- forensic science
Find your passion!!
Dr. Pedro. Sanchez, MD, MSCE, FAAP, FACMG
Dr. Laura Li, PhD, FACMG
UCLA 4 years
Major: Cell & Molecular
4 years Medical School
3 years Pediatrics
3 years Genetics
Where can I find the instructions to make a person?
Why are my eyes brown?
What carries the instructions or blue print to make a person?
What is 3,000,000,000
letters long using only a
4 letter alphabet A C T G?
What substance is found in the nucleus of plant and animal cells?
What substance can be found at a crime scene that would identify the culprit?
What can be used to identify a specific killer shark?
What can a doctor test to see if a medical problem is genetic?
If we ever caught an alien:
What would we test to prove that they are not from this planet?
Why are my eyes Brown?
Why do some dog breeds have more problems than others?
1965 Shelby Cobra Mustang
Pediatrician & Geneticist
What do these kids all have?
What Do These Kids Need?
To have fun
Thorough physical examination
A doctor that knows about their genetic condition
WHAT IS DNA?
4 years Undergraduate
5 1/2 year Ph.D. Training
4 years Post Graduate Fellowship
2 years Medical Genetics Training
Mr. van Breman
Coding & Programming
Pictures from flicker, google or or Presi
WHAT IS DNA?
Why do we have mutations?
Get in Groups of two
What is a "TRAIT"?
What features would you use to describe your partner?
10% of ALS is due to mutations in one of 8 genes
QUESTION: If there are 5000 new cases of ALS each year, how many will find a cause of their disease?
Clinical Genetic Molecular Biology Scientist Training
Amyotrophic Lateral Sclerosis (ALS)
Why do people need a diagnosis?
To give them answers
To help them find others
To help them live healthier
Who has DNA?
Who will go
What do you
love to study?