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DNA Viruses and Virus Structures
Transcript of DNA Viruses and Virus Structures
Fusion of viral envelope w/the host cell membrane. Uncoating: The removing of all or part of the capsid exposing nucleic acid. Macromolecular Synthesis: Production of proteins, nucleic acid, and other components. Some components are made in tremendous excess. Assembly: Structural proteins and genome assemble. Often viral enzymes assembled into virions. Release: Budding through membrane or lysis of membrane Adenoviridae Eye infections
Gastroentritis (in children) Adenovirus diseases: Papillomaviridae Skin & genital warts
Mucus membrane infections
Human Papilloma Virus (HPV)
Molecular Assays (PCR) Papillomavirus diseases Diagnosis Hepadnaviridae Hepatitis Hepadnavirus diseases: Transmission: Perinatal exposure, sexual contact, direct contact w/ body secretions, blood, and drug abuse Other info: Enveloped
Has two antigens: Surface Ag, Core Ag
Virus can be latent in the liver
90% of acute infection w/resolution
Chronic: Progressive liver damage and liver cancer
Not isolated in culture: Serologic tests, detection of antigens and molecular tests
Prevention: HBV vaccine
Partial Single Stranded DNA Herpesviridae Info: Has an envelope
Latency from years to decades w/no symptoms
Eight Herpes viruses in humans are known Alphaherpesvirinae Neurotropic: Infects nervous tissue
Short reproductive cycle Diseases: Herpes Simplex Virus 1 (HSV 1): Above waist - Facial, labial, ocular lesions, and cold sores Herpes Simplex Virus 2 (HSV 2): Below waist - Genital warts Varicella-Zoster Virus (VZV): Chickenpox -> latency -> Shingles Betaherpesvirinae Lymphotropic: infects cells - Cytomegaly or Reactive Lymph (infectious mononucleosis
Long reproductive cycle CMV - Reactive lymph
Rosela - In children Diseases: Gammaherpesvirinae Lymphotropic: Infects T and/or B Lymphocytes Diseases: EBV - Factor in cancer
Herpesvirus B - Factor in Karposi's and Sarcoma HSV 1
---------- Alpha Beta Gamma Got Herpes? Latent in WBC & various organs
Transmission: Contact, blood, and transplacental
Congenital disease in newborns
Like Infectious Mononucleosis (reactive lymphs)
Symptomatic: In immunocompromised will affect kidneys, eyes and lungs
Diagnosis: Blood, urine, and throat specimens
Culture: Shell vial culture
Serology: FAStain PCR Closer look at CMV Source: All information was taken off notes in class.
Instructor : Begum, Pathogenic Bacteriology 2/Virology section Prezi done by: Christopher Brewer
(Extra credit pending) Christopher Brewer 1: QUIZ 1: Name the 4 DNA viruses
2: How does a virus attach to a cell?
3: How do new virus leave a cell?
4: What are the virinae of Herpesviridae?
5: What's the inner most wall of a virus?
6: What's stuff inside a virus?
7: How is Hepadnaviridae different from the others?
8: What child disease does Adenoviridae cause?
9: What does HPV stand for?
10: What diseases does Gammaherpesvirinae cause? 10: EBV, Herpes Virus 8 1: Adenoviridae, Papillomaviridae, Hepadnaviridae, Herpesviridae 2: Glycoprotein Spikes and the cell's receptor 3: Budding from wall or lysis of cell 4: Alpha, Beta, and Gammaherpesvirinae 5: Caspid/protein coat 6: Nucleic Acid 7: It's partially single stranded 8: Gastroentritis 9: Human Papilloma virus Questions Answers