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Fatty Liver Disease

Exploring how Fatty Liver Disease effects the human organism's ability to maintain homeostasis.
by

Amanda Wolfe

on 29 April 2011

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Transcript of Fatty Liver Disease

Non-alcoholic Fatty Liver Disease Non-alcoholic Fatty Liver Disease (NAFLD)
develops due to fat deposition in the liver (steatosis) which can lead to inflamation of the liver (hepatitis). If inflamation occurs scar tissue may form and can lead to cirrosis of the liver (fibrous scare tissue formed). Image retrieved from: http://www.ehow.co.uk/about_5114031_symptoms-
nonalcoholic-fatty-liver-disease.html Normal Healthy Liver
(view of liver cells- Hepatocytes)
play an important role in:
* Carbohydrate, protein,
and lipid metabolism
* Production of bile
* Production of hormones
* Glucose storage (in the form of glycogen)
*Filtration of toxins from blood
*conversion of ammonia to urea Cells of a liver with NAFLD Note fat deposits and damage to liver
cells Cirrohsis of the liver - damage to liver tissue due to fibrous scars and nodules Images retrieved from: http://en.wikipedia.org Occurence of NAFLD is closely linked with
diabetes, insulin resistance, and obesity.
Image retrieved from: http://www.digestive.niddk.nih.gov/ddiseases/pubs/nash/images/liver_damage.gif Symptoms of NAFLD:
Early symptoms may include; fatigue, weight loss, and weakness
If the disease persists and inflamation of the liver leads to cirrohsis the person will present signs of liver failure
- Ascites - fluid retention in abdomen and legs
- Dark stool indicating bleeding in the intestines
- Jaundice
- Confusion and memory loss Image retrieved from:
http://meded.ucsd.edu/clinicalimg/abdomen_ascites6.jpg Homeostasis:
If NAFLD continues to the more severe steatohepatitis and then to cirrohsis the ability of the body to maintain homeostasis is compromised.
- High levels of toxic substances in blood
(i.e. Jaundice - build up of bilirubin in blood
part of the break down of hemoglobin
which is normally excreted through bile
and urine) Image retrieved from:http://upload.wikimedia.org/wikipedia/commons/thumb/1/19/Jaundice08.jpg/190px-Jaundice08.jpg build up of bilirubin causes
yellow discoloration of skin and
whites of the eyes
Muscle wasting due to the
inability to metabolize protiens Internal bleeding: The liver normally filters blood coming from the stomach. With cirrohsis the pathways for blood flow are blocked and resistance causes blood to flow more heavily through other areas like the esophagus. Image retrieved from: http://upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Esophageal_varices_-_wale.jpg/230px-Esophageal_varices_-_wale.jpg Hepatic Encephalopathy
* Loss of mental functions
*thought to be due to the
accumulation of ammonia
Treatments for NAFLD Reduce weight
healthy diet and exercise
avoid alcohol and medications

***Some trials have been started to test the efficacy of antidiabetic drugs - although the understanding of how insulin resistance contributes to Steatohepatitis is still not fully understood.

*** If cirrohsis occurs the only treatment is to secure a liver transplant. Steatosis occurs when the rate of fat from plasma is absorbed
faster than the rate of oxidation and export of fatty acids in the liver. 2-5% of Americans
are affected by NAFLD There is a strong correlation between
obesity and NAFLD. More cases are
occuring along with the rise in obesity in the
United States Image Retrieved From: Centers for Disease Control and Prevention
http://www.cdc.gov/obesity/data/trends.html Reference Page:





Adams, Leon A.. Paul Angulo, and Keith D. Lindor Nonalcoholic fatty liver disease, Web. 15 April 2011. “Nonalcoholic fatty liver disease.” Division of Gastroenterology and Hepatology, Mayo Clinic and College of Medicine, Rochester, Minn. Web. 15 April 2011
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC554876/?tool=pmcentrez

Lee, Dennis. MD. Jay W. Marks, MD. “Body Fat, the Silent Killer.” medicinenet.com. medicinet, Web. 15 April 2011.
http://www.medicinenet.com/script/main/art.asp?articlekey=46582&page=2

“Non-alcoholic fatty liver disease” 2011.Wikimedia Foundation Inc. 15 April 2011 .http://en.wikipedia.org/wiki/Non-alcoholic_fatty_liver_disease

“Non-Alcoholic Fatty Liver Disease.” UCSF Medical Center. December 1, 2010. Web 15 April 2011.
http://www.ucsfhealth.org/conditions/non-alcoholic_fatty_liver_disease/

Diagnosis blood tests -> elevated liver enzymes
liver ultrasound
Computed Tomography (CT)
Liver biopsy
Full transcript