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Mostafa Mo'men

on 18 October 2012

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Transcript of sulphonamide

sulphonamide Synthetic antimicrobial agents
,contain sulfonamide group Mech. of action Uses Side Effects Cases Products Drug-Drug Interactions -sulfonamide inhibt this enzyme as they are structural analogs and competitive antagonists of PABA

-so the microorganism
will be "starved"
of folate and die -Gastrointestinal upset.

-Allergies to sulfa-based medications
typically cause skin rashes,
hives, trouble breathing
or swallowing and warrant. -Sulfamethoxazole enhance the blood-thinning effects
of warfarin (Coumadin), possibly leading to bleeding.

-Sulfamethoxazole increase the metabolism of cyclosporine (causing loss of effectiveness of cyclosporine)

-All sulfonamides can crystallize in urine when
the urine is acidic. -female at 29 years old
-with dysuria and poly uria and fever
- by laboratary diagnosis to nitrite it
is positive and there was E-coli
-the female was suffer
from urinary tract infection and
-treated by
trimethoprim +sulphamethaxzole -septazol

-treat a wide variety of bacterial infections
(e.g., middle ear, urine, respiratory and
intestinal infections).

- prevent and treat a certain type of
pneumonia (pneumocystis-type)

-It won't work for viral infections (e.g., flu) -Sulfonamides have many functions
some of them used as diuretics like "Furosemide"
-others used as Anticonvulsants like "Acetazolamide"
-and alot of them used as Antibacterial Drugs like
"short acting Sulfamethoxazole" -folic a is important for bacteria as it's an important metabolite in DNA synthesis folic acid synthesized from
the reaction between
para-aminobenzoic acid (PABA)
and di hydro petorate di phosphates in the
presence of the enzyme
dihydropteroate synthetase (DHPS)
Full transcript