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IP 141 REPORT - TINCTURES AND ELIXIR
Transcript of IP 141 REPORT - TINCTURES AND ELIXIR
*Alcohol-soluble and water-soluble ingredients are generally dissolved separately.
* Aqueous added to alcoholic to maintain alcoholic strength
* Talc as a frequent filter aid by absorbing excessive oils
* Glycerin, syrup, sorbitol and propylene glycol as contributors to the solvent effect and stabilizers
At the end of this report, the student should be able to:
* Define elixirs and tinctures
* Differentiate elixirs and tinctures from other liquid dosage forms
* Name the different forms of elixirs and tinctures, and differentiate each from one another.
* Describe the characteristics, advantages and limitations of tinctures and elixir.
* Describe the method and outline the steps used in preparing tinctures and elixir.
* Clear, sweetened hydroalcoholic solution intended for oral use and usually flavored to enhance palatability
* Usually less sweet and less viscous
* Better able than aqueous syrups to maintain both water-soluble and alcohol-soluble components in solution
* Preferred to syrups in manufacturing due to stability and ease of preparation
Tinctures and Elixirs * May be useful in the extemporaneous filling of prescription involving:
* The addition of a therapeutic agent to a pleasant-tasting vehicle
* Dilution of an existing medicated elixir
* In selection, solubility and stability of the drug substance in water and alcohol are concerned, as well as alcoholic concentration, flavor and color.
* Most commonly used: aromatic elixir, compound benzaldehyde elixir and isoalcoholic elixir
* Employed for the therapeutic benefit of the medicinal agent
* Most official and commercial elixirs contain a single therapeutic agent.
Tinctures are alcoholic or hydroalcoholic solutions prepared from vegetable materials or from chemical substances. (USP 30, 2007)
Elise Danielle Garcia
Chelsea Lyn D. Valdez
IP 141 Reporting
December 4, 2012 Antihistamine Elixir
- acidic in pH for the drugs to remain freely soluble in water
Barbiturate Sedative and Hypnotic Elixir
- the strength permits convenient adjustment of dosage
- generally employed for children
Characteristics, Advantages and Limitations Proportion of drug - not uniform but varies according to the established standards for each
Traditional – 10 g in 100 mL
Alcoholic content – tight containers, away from direct sunlight and excessive heat
Light-resistant containers – photochemical change
History and concurrent medicines (no to antabuse)
Drowsiness --> consult physician
Uses of Ingredients Alcohol - 15-80%; against microbes; keeps alcohol-soluble extractives in the solution.
Solvent should not be too diverse
Extracts - evaporation of all or nearly all of the solvent, and by adjustment of the residual masses or powders to the prescribed standards.
Fluidextracts - each mL contains the therapeutic constituents of 1 g of the standard drug that it represents.
Fluidextracts and Extracts Preparation Extraction (Digestion, Infusion, Percolation, Maceration, Decoction)
Mix for 15 minutes Percolator Maceration
Sample Formulas and Traditional Tinctures in the Philippines Black Walnut Tincture - restoring hormonal balance, and relieving pain and are non-FDA reviewed or approved, natural alternatives, to use for, Hot Flashes, and Menopause
Eclipta Tincture - internal hemorrhage (especially bleeding in the respiratory and gastrointestinal tracts) such as pulmonary tuberculosis, gastrointestinal hemorrhage.
- hydroalcoholic solution
- stable and easy preparation
- alcoholic or hydroalcoholic solutions prepared from vegetable materials or from chemical substances.
- Percolation and Maceration
References Allen, L. V., Ansel, H. C. & Popovich, N. G., 2011. Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems. 9th Edition. Philadelphia, U.S.A.: Lippincott Williams & Wilkins, pp. 353-357.
Beringer, P., DerMarderosian, A., Felton, L., Gelone, S., Genarro, A. R., Gupta, P. K., Hendrickson, R., Hoover, J. E., Popovick, N. G. & Reilly, W. J., 2006. Remington: The Science and Practice of Pharmacy. 21st Edition. New Delhi, India: Wolters Kluwer (India) Pvt. Ltd., p. 757.