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Transcript of Zovirax
-Prophylaxis of Herpes Simplex infection in immune-compromised patients
-Treatment of Varicella infection
Properties -Acyclovir is partially absorbed from the gut and mean steady state peak plasma conc. following dose of 200 mg administered 4 hours
-Most of the drug is excreted un changed by the kidney
-Renal clearance of Acyclovir is greater than Creatinine clearance indicating that tubular secretion in addition to glomerular filtration contributes to renal elimination of the drug
-Acyclovir is a synthetic Purine nucleoside that interferes with viral DNA polymerase and inhibit Viral Replication that lead to termination of chain of virus
Side effects -Anemia, Leucopenia, headache and anaphylaxis
-Vomiting, nausea, diarrhea and fever
-Increase serum creatinine and blood urea nitrogen that leads to renal failure
Hypersensitivity of Acyclovir It must be used under control in case of renal impairment, elderly patients and patients with hydration status 200 mg taken 3:4 times daily THANK YOU :)