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Stem Cells

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Kareem Osman

on 31 July 2013

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Transcript of Stem Cells

Human Embryonic Stem Cells Bone Marrow
Stem Cells Valve replacement The obtaining of stem cells STEM CELLS Cardiac Bone Comparison Stem Cells Therapy Diseases Diseases Repairing
Heart Mr. Tala't 65 years old

Myocardial infarction

Angioplasty BUT... If we are able to Extract , Isolate , Culture & Inject stem cells into the heart successfully , The stem cells would divide into various cardiac cells and help in cardiac regeneration Embryonic bodies Problems The most common method to facilitate cardiomyocyte formation from hESCs is to initiate formation of embryonic bodies. differentiate into mesenchymal stem cells (MSCs) and hemangioblasts,

which can generate cardiomyocyte, hematopoietic and endothelial cells . As hESCs differentiate toward cardiomyocytes, there is a reduction in the expression of pluripotent transcription factors – OCT4, Nanog and SOX 2 – and a concomitant increase in the expression of cardiac transcription factors – NKx2.5, MEF2c and GATA4. Ethical Cancerous Tumors Cell Loss Ventricular
arrhythmias Human Umbilical Cord Blood Stem Cells - a source of hematopoietic, endothelial and MSCs. - development of vascular grafts and heart valves for the treatment of newborns with congenital heart defects - less CD3+, CD4+ and CD8+ immune cells than human adult blood cells, immunologically native - can be cryopreserved for periods of 15 years or more - limit the size of myocardial infarctions Angioplasty Vs Stem cells Therapy Heart Transplantation Vs Stem Cell Therapy Cardiac Bypass Surgery Vs Stem Cell Therapy WHY ! So , What do you think !? Stem Cells Therapy ...
HOPE or HYPE Repairing

Use a crutch Spontaneous healing Functional restoration without scarring So , Mesenchymal Stem Cells - Natural System of tissue repair - Clinically,MSCs can be used as cell suspension expanded by culture or just as bone marrow concentrate . But ... - Cell amplification by culture is not free from the dangers of bacterial contamination, or cellular transformation , influencing MSC’s differentiation capacities. WHY !? MSCs Therapy used in : Osteonecrosis Bone defect repair Osteogenesis imperfecta Osteoarthritis Heart Failure Indications Problems - expression of cardiac specific genes - troponin , myocardial heavy & light chain Trials - formation of artificial myocardial infarction in rats - Histopathological examination after the end of study - Differentiation into embryonic nodal like , atrial like & ventricular like cells - Adrenergic , cholinergic receptors - Lack of gap junction (connexin 43) , lack cell to cell communiction Biological pacemaker - Immuno-compromised pigs with complete A-V block

- regular sustained rhythm with a rate of 59 ± 11 b/min which maintained a stable COP - Bone marrow paracrine action.

- Release of biologically active proteins.

- Signaling the growth of new blood vessels and heart muscles. Cardiac progenitor cells
- less than 1 % of cardiac muscles
- ISL-1
- C-kit
- Sca-1 Chronic Ischemic
heart diseases Designed By : Kareem Osman Presented By : Mohammed Eid
Ahmed Mare'y
Kareem Osman Take Home Message Sharing is Caring
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