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what is the difference between autocrine, paracrine, endocri

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siobhan van der pool

on 22 October 2014

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Transcript of what is the difference between autocrine, paracrine, endocri

What is the difference between autocrine, paracrine, endocrine and exocrine?
Definitions
Endocrine: chemicals are secreted into the blood and carried by the blood and tissue fluids to the cells they act upon.
e.g. pancreas produce insulin and glucagon to regulate blood sugar levels

Exocrine: external secretion glands such as
sweat glands
that release a secretion through a duct to the surface of an organ. (the external environment)

What is the difference between Autocrine and Paracrine?
Autocrine molecules act on the same cell that produced them, however paracrine molecules act on nearby cells.
Autocrine signals include extracellular matrix molecules (provide structural and biochemical support to the cells )
e.g. chemical transmitted from nerve to muscle cells that causes the muscle cell to contract.
Definitions
Autocrine: mode of hormone action to which hormons bind to receptors on to the cell and affects the cell that produces it.
e.g.

growth factors that stimulate cell division.


Paracrine: describes hormone action where hormones are released from cells and bind to receptor on nearby cells and affects their function.
cytokines that cause inflammatory response / release of neurotransmitters of synapses in the nervous system.



Summary

Autocrine: hormones that act on the cell that produced them
Paracrine: local hormones diffuse a short distance to other cells
Endocrine: Hormones are secreted into the blood and acts at long distance , no ducts.
Exocrine: Non hormone secretion into ducts to external environment
Hormones produced by the Autocrine and Paracrine are restricted to working within the cytoplasm of the cell where exocrine and endocrine hormones move within the body of the organism.
What is the difference between endocrine and exocrine?
The main difference would be the use of a medium. Endocrine glands secrete hormones into the blood
Endocrine responses are slow and long because the hormone needs to be filtered out of the blood before it can take effect.

Exocrine glands have ducts which the secretion travels through to which the secretion takes action
e.g. sweat

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