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Transcript of Parkinson's Disease
has 2 of the 4 main symptoms. They would have any 2 of
the following, trembles or shaking, slowness of movement, stiffness or rigidity in arms or legs, and loss of balance. Treatments? What is Parkinson's? The body suffers a damage on the dopamine part of the brain. From Understanding the Molecular Causes of Parkinson's disease by A. Wood-Kaczmar, S. Gandhi, N.W. Wood, (2006) "Parkinson's disease (PD) is a neurodegenerative disease that is both common and incurable" (Page 521). Dopamine supplies the central nervous system. When deficient in dopamine, the nerves have trouble functioning. The nerves affect the movement function. A Little History on
Parkinson's Disease. Parkinson's has been known since 5,000 B.C.
Then known as Shaking Palsy.
The first person to take an interest in the shaking palsy was British Doctor James Parkinson.
He wrote a paper in 1817 titled "An Essay on the Shaking Palsy." Symptoms Possible symptoms: Trembling in hands, arms, legs, jaw, and face. Then rigidity, or stiffness of limbs. Bradykinesia, or slowness of movement, and impaired balance and coordination. They could utter monosyllables, while they struggled, in a violent expiration, and a low voice and indistinct articulation, and was only understandable to few (Dr. James Parkinson, 1817, Page 40). cognitive and thinking problems, and dementia.
Final stages can cause Pneumonia, choking, and sometimes depression. Cause of Parkinson's The cause of Parkinson's Disease is, of this time, uncertain.
Some factors haven't been concluded yet. Although
Christian Nordqvist stated (2012) "Neurodegeneration was also identified in the substantia nigra six days after the mild
stroke - dopaminergic neurons had been destroyed" (para. 9) Many other theories have been considered causes of Parkinson's Disease. Obesity, hereditary, or stokes are all theories. Inheritance How people get Parkinson's is unclear.What we do know is that elder people are more likely to get Parkinson's. 1 of every 250 over 40 get Parkinson's and every 1 in 100 over 60. SNCA, LRRK2, Parkin, PINK1, DJ1, ATP13A2, PLA2G6, FBXO7, UCHL1, GIGYF2, HTRA2, and EIF4G1 are the 12 types of mutations. Claudia Schulte and Thomas Gasser declared, "However, replication studies have failed to demonstrate the pathogenicity of these mutations." (page 72). Showing that these mutations can't produce a real pathogen. Parkinson's has some medication, but each patient can react different to it. Nature Publishing (2010) “The patients had seemed to benefit for a time.” Referring to the patients that had dopamine implants. Their autopsies showed that the implants were still there, but ineffective after a certain time. They were embryonic dopamine trial patients. It is recommended for younger patients. Dr. James Parkinson Parkinson's is mainly affecting people aged over 50. An average 50,000 Americans are diagnosed each year and 7-10 million worldwide are living with it. Yet, could be more due to the fact that some think it is just an effect of aging. Men are known to be 1.5 times more likely to have Parkinson's. There are reports on races with Parkinson's, but each were unclear, had different results, and were from more than a decade ago. Schulte C., Gasser T. (2011). Neurodegenerative Diseases.
Genetic basis of Parkinson's disease: inheritance,
penetrance, and expression. Page 72.
Nordqvist C. (2012). Parkinson's Disease. Silent Stroke
Can Cause Parkinson's Disease. paragraph 9
Parkinson J. (1817). Shaking Palsy. An Essay on the
Shaking Palsy. Page 40.
Wood-Kaczmar A.,Gandhi S.,Wood N.W.(2006). Molecular
Causes of Parkinson's Disease. Understanding the Molecular Causes of Parkinson's Disease. Page 521.
http://www.ncbi.nlm.nih.gov/pubmed/17027339 Famous People
with Parkinson's Muhammad Ali
Michael J. Fox
Pope John Paul II
Antanas Mockus And many more. By Austin