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Borrelia burdorferi

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by

Brett Ralston

on 21 February 2017

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Transcript of Borrelia burdorferi

Spirochete
Undefined Gram Stain
Tick-borne
Three strains of disease causing Bacteria
Borrelia burgdorferi sensu stricto
Borrelia garinii
Borrelia afzelii
Linear Chromosome
Epidemiology
Blacklegged Tick most common in North America
30,000 cases per year in US
Rate is increasing
The Tick gets the bacteria from natural reservoir
White-footed mouse
7% of cases are asymptomatic
Virulence Factors/ Pathogenicity
ospC
Production begins in feeding nymph Ticks salivary gland
In mammalian host amount decreases after early infection
vlsE gene
Up regulated in mammalian host
Allows for host immune evasion
antigenic variation
Alters surface proteins
General Information
Disease
Diagnosis
Two-tiered Testing
Enzyme immunoassay (ELISA)
Then IgM and IgG Western Blot
Tests for antibodies
Borrelia burgdorferi can be grown on Barbour-Stoenner-Kelly (BSK) medium.
13 different ingredients
Rabbit serum
Treatment
Antibiotic treatment
Doxycycline, amoxicillin, or cefuroxime axeti
LYMErix
Taken off market in 2002
Was only available Vaccine
Targeted ospA
Low demand
Borrelia burgdorferi
by: Brett Ralston

Early (3-30 Days)
"Bulls eye" Rash
Facial Palsy
Stiff joints
Late (Months After infection)
Multiple Bulls eye rashes
Severe arthritis
Shooting pains
Nerve pain
Meningitis
Post Treatment Lyme Disease Syndrome
Cause unknown
Symptoms persist for months after treatment
Mortality Rate
Very Low (144 in 1999-2001)
Prevention
During tick season wear clothes that cover your arms and legs when outside
When you get home check for ticks and remove any as soon as possible
Wear DEET sprays
References
Tilly, K., Rosa, P. A., & Stewart, P. E. (2008). Biology of Infection with Borrelia burgdorferi. Infectious Disease Clinics of North America, 22(2), 217–234. http://doi.org/10.1016/j.idc.2007.12.013
Lyme Disease. (n.d.). Retrieved February 19, 2017, from http://textbookofbacteriology.net/Lyme.html
Wagner, B., Freer, H., Rollins, A., Garcia-Tapia, D., Erb, H. N., Earnhart, C., … Meeus, P. (2012). Antibodies to Borrelia burgdorferi OspA, OspC, OspF, and C6 Antigens as Markers for Early and Late Infection in Dogs. Clinical and Vaccine Immunology : CVI, 19(4), 527–535. http://doi.org/10.1128/CVI.05653-11
The surface lipoprotein E (VlsE) of the Lyme disease spirochete bacterium. (n.d.). Retrieved February 19, 2017, from http://www.proteopedia.org/wiki/index.php/The_surface_lipoprotein_E_(VlsE)_of_the_Lyme_disease_spirochete_bacterium
Borrelia burgdorferi. (n.d.). Retrieved February 19, 2017, from http://web.uconn.edu/mcbstaff/graf/Student%20presentations/Bburgdorferi/bburgdorferi.html
Highlighted Proteins of Lyme Disease. (2016, February 8). Retrieved February 19, 2017, from http://www.proteopedia.org/wiki/index.php/Highlighted_Proteins_of_Lyme_Disease#VlsE_and_Lyme_Disease
Kugeler, K. J., Griffith, K. S., Gould, L. H., Kochanek, K., Delorey, M. J., Biggerstaff, B. J., & Mead, P. S. (2011, February 01). A Review of Death Certificates Listing Lyme Disease as a Cause of Death in the United States. Retrieved February 19, 2017, from https://academic.oup.com/cid/article/52/3/364/307928/A-Review-of-Death-Certificates-Listing-Lyme
(2016, August 19). Retrieved February 19, 2017, from https://www.cdc.gov/lyme/index.html
Gonzalez, L. (2016, June 13). Resurrecting A Vaccine For Lyme Disease. Retrieved February 19, 2017, from http://www.medicalnewstoday.com/articles/260471.php
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