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Parkinson's Disease

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by

Mandan Quinn

on 25 September 2013

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Transcript of Parkinson's Disease

Parkinson's Disease
Causes
Scientists believe PD is caused by lack of dopamine in a region of the brain called the SUBSTANTIA NIGRA.
Although they don't know why that certain part is targeted, or what targets it, at different times throughout history it was thought that chemicals like herbicides (agent orange,) or industrial toxins, insecticides, pesticides, petroleum wastes, well water and head trauma have caused PD.
Heredity may play a role.
Occupations like boxing ad welding have been associated with PD
Testing
Although there is no precise test for PD, CT scans are used to look for signs of it. And PET scans are used to assess activity and function of brain regions involved in movement.
Treatment
There is no getting rid of PD once you are diagnosed with it, but there are medications that you can take to ease the symptoms.
Tremors
Postural instability (lack of balance/unsteadiness while standing)
Difficulty walking
Loss of smell
Micrographia (a small, cramped handwriting)
Pain (dull ache, persistent nagging)
Leg cramping
Headaches
Difficulty speaking; Hyphonia; softness of voice)
Facial Masking (lack of expression) aka poker face
Symptoms worsen over time
Mostly common in older people
Mostly common in men.
Signs and Symptoms
Levodopa (L-dopa)
Entacapone (Comtan)
Pramipexole dihydrochloride (Mirapex)
Ropinirole (Requip)
Pergolide (Permax)
Outcome/Prognosis
People live 15-25 years from diagnoses, if they are taking medication; as apposed to 5-10 without it.
Complications with being bed-bound cause death. Such as bed sores becoming infected.
Not moving legs from being bed-bound cause blood clots in the legs, which then spread to the lungs.
Some develop difficulty swallowing which causes them to choke on their food.
Research
There are several different foundations trying to find a cure for Parkinson's
Why I Chose Parkinson's Disease
A recent Harvard study found that redheads have an almost 90 percent greater chance of developing the disease. Why? Possibly because of that same gene mutation: It influences another type of gene that, when also mutated, can be associated with Parkinson's.
Full transcript