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Amruta Mhashilkar

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This hypervariable region of an antibody has the greatest variability and contributes most to antigen binding.

Question 22:

Congenital
Combinatorial
Junctional
Nuclear

Q21 Answer:
What is …?

Diversity of antigen receptors (BcR complex/antibody) is generated through combinations of the V, D, & J gene segments.

This type of diversity is nearly unlimited, produced by 2 types of sequence changes, and maximizes variability in Fab region of antibodies.

Question 21:

B cells recognize antigen with their ______, which can distinguish between lipids, polysaccharides, & proteins unlike _______.

Question 20:

Diversity segment
Recognition phase
Somatic recombination
Somatic hypermutation

Q19 Answer:
What is …?

The increased frequency of this process selects for high affinity antibody to bind antigen.

Question 19:

Constant regions, identical
Variable regions, different
Antigenic determinants, identical
Antigenic determinants, different

Q18 Answer:
What are ____ & _____?

NK cells, largest epitopes
B cells, lowest antigenicity
T cells, highest antigenicity
Plasma cells, smallest epitopes

Q17 Answer:
What are ___ & ____?

Most antibodies and ___ ___ respond to the site of _______ ______ on a foreign molecule.

Question 17:

Affinity
Avidity
Hydrophobic interactions
van der Waals interactions

Q16 Answer:
What is ….?

IgA
IgM
IgG
IgE

Q15 Answer:
(choose 2)
What are ….?

Activation of the classical complement pathway is an important secondary effector function of these 2 antibody classes.

Question 15:

Antibody structures are perfectly suited to directly link
_______ to _______.

Question 9:

Classes of antibodies are named according to the _____ _____.

Question 8:

Disulfide bond
Hinge
Fab
Fc

Q7 Answer:
What is ….?

Disulfide bond
Hinge
Fab
Fc

Q6 Answer:
What is …?

The region of the antibody that is constant & biologically active.


Question 6:

Q5 Answer:
What is …..?

Allotype
Idiotype
Isotype
Immunoglobulin

Q4 Answer:
What is …..?

IgA
IgM
IgG
IgD

I am the only antibody class that is not secreted.

Question 4:

Blood Transfusion
Recent Infection
Old Infection

Q3 Answer:
What is a …..?

Q2 Answer:
(choose 2)
What are …. ?

IgA
IgM
IgG
IgD

These two antibody classes provide neonatal immunity.

Question 2:

IgA
IgM
IgG
IgE

Q1 Answer:
What is …. ?

Humoral
Neonatal
Mucosal
Cellular


Q25 Answer:
What is…?

Each day, a healthy adult produces nearly 3 grams of antibody. Approximately 70% of these antibodies are involved in ______ immunity.

Question 25:

NK cell
B cell
Neutrophil
Eosinophil

Q24 Answer:
What is…?

A special type of ADCC is needed to defend against helminths. These large organisms are opsonized with IgE antibodies and then destroyed by this cell type.

Question 24:

Appendix
Tonsils
Spleen
Kidney

Q23 Answer:
What is…?

This organ contains a large number of phagocytes and is important for clearance of opsonized bacteria. People who have this organ removed are at higher risk for disseminated infections by encapsulated bacteria.

Question 23:

CH2
CDR3
VL1
FAB4

Q22 Answer:
What is ….?

antibodies, macrophages
antibodies, NK cells
receptors, T cells
MHC I regions, T cells



Q20 Answer:
What are ___ & ____?

One antigen may have several
_____ _____ that ______ antibodies recognize, effectively multipying the immune response to the antigen.

Question 18:

The strength of a single Ag-Ab bond.

Question 16:

IgA
IgM
IgG
IgE

Q14 Answer:
What is….?

Mast cell degranulation is an important secondary function of which antibody class?

Question 14:

Intracellular, extracellularly
Extracellular, intracellularly

Q13 Answer:
What are ____ & _____?

Antibodies function to attack ______ pathogens, such as bacteria, because they cannot attack viruses, which live ________, until a secondary infxn.

Question 13:

Glycoprotein
Immunoglobulin
Gammaglobulin

Q12 Answer:
What is …?

This term implies a general function of antibodies.

Question 12:

Trigger complement
Recognize antigen
Improve opsonization
Phagocytosis

Q11 Answer:
What is …?

This is the primary function of an antibody.

Question 11:

constancy, antigen
recognition, B cell
specificity, antigen
specificity, B cell

Q10 Answer:
What is …?

This variable region gives an antibody ______ for an ______.

Question 10:

B cell, T cell
Antigen, immune cell
Antibody, T cell

Q9 Answer:
What are ____ & ____?

V regions
D regions
Light chains
Heavy chains

Q8 Answer:
What are ….?

This region of the antibody binds the epitope.

Question 7:

Another term for “class-y” antibodies.

Question 5:

Elevated levels of the IgM antibody class in your bloodstream indicates that you have had a ________ ________?

Question 3:

The secreted dimerized form of this antibody class is extremely important to mucosal immunity.

Question 1:

Answers
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