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Thyroid Hormones

Control of Metabolism
by

Bradley Vink

on 27 April 2010

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Transcript of Thyroid Hormones

Hormones that
affect metabolism Cellular Respiration Glucose + Oxygen CO2 + H2O + heat 60% of energy in glucose that is oxidized is released as heat 40% is transferred to ATP Thyroid Gland Located at the base of the neck Wraps around the trachea







Higher amounts of thyroid hormones result in higher metabolic rates Control of thyroid hormones involves negative feedback loops



TRH (Thyroid Releasing Hormone)
is released by the hypothalamus TRH




TSH TSH = Thyroid Stimulating Hormone To the thyroid TSH




T3 - Triiodothyroxine



T4 - Thyroxine Both T3 and T4 (thyroxine)
are based on the
amino acid tyrosine Negative feedback Thyroxine provides negative feedback to the hypothalamus to stop the secretion of TRH Thyroxine TSH Iodine is an important component of thyroid hormones Where do you get iodine in the diet? If iodine levels are too low..... ...secretion of thyroxine slows,... ...more TSH is produced,... ...thyroid continues to be stimulated ,... thyroid gland expands, and develops into a goiter. Thyroid also produces calcitonin Calcitonin acts on bone cells to lower blood calcium levels



Parathyroid Glands 4 small glands located on the posterior side of the thyroid gland






Parathyroid gland detects low blood calcium Produce PTH (Parathyroid hormone) releases PTH



PTH acts on
















Bones Kidneys Intestines to release Ca2+ to reabsorp Ca2+ from filtrate in nephron to reaborb Ca2+ from digestion Ca2+ levels increase Negative feedback on Parathyroid Gland






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