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Carbapenemasas

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by

Rodrigo Valenzuela

on 11 June 2013

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Transcript of Carbapenemasas

Antibioticos Antibioticos Betalactamicos Penicilinas

ampiciclinas

Cefalosporinas

Monobactámicos Betalactamasas Betalactamasas de
espectro ampliado
( BLEA) Carbapenems Resistente a las betalactamasas Carbapenemasas a excepcion de Infecciones por bacilos gram negativos
con amplio espectro de actividad bactericida y son sumamente resistentes a las betalactamasas Anillo betalactamico anillo químico compuesto de 3 átomos
de carbono, un átomo de nitrógeno y uno
de Oxígeno. Inhiben la síntesis de la pared celular
en bacterias Gram Positivas ENZIMAS http://www.ispch.cl/sites/default/files/documento/2012/04/reporte_kpc_sochinf.pdf Clases de carbapenemasas: •Clase A: Hidroliza a todos los antibióticos b-lactámicos y son parcialmente inhibidos por ác. Clavulanico •Clase B: Hidroliza todos los b –lactámicos excepto aztreonam, podría ser inhibido por ác. Clavulánico, requiere zinc para la actividad enzimática y es inhibido por EDTA •Clase D: Hidroliza oxacilina, menos probable de hidrolizar carbapenems.
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