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SICKLE CELL ANEMIA

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Alex R

on 10 February 2014

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Transcript of SICKLE CELL ANEMIA

SICKLE CELL ANEMIA
What causes Sickle Cell Anemia?
How is it inherited?
How is it diagnosed?
What are the symptoms?
What are the current treatments?
What are the past treatments?
Who discovered the disorder?
Ethnic/gender-linked?
Legislation?
Future research?
Sickle cell control act (SCTA)
was first signed by president
Nixon in 1972. $10 million was
provided to the sickle cell anemia
programs.
Scientists think that blocking the production of BCL 11A protein is a cure. It works in mice but they are going to research more before human testing.
Sickle cell anemia shows up mostly in Africa, Greece, Turkey, Italy, Arabian peninsula, India, South America, Central America, and parts of the Caribbean. More commonly found where malaria is. This is not a gender-linked disease.
A dentist named James Bryan Herrick and his intern Ernest Edward Irons discovered the disorder in 1910. Sickle cell anemia is the proper name for sickle cell disease formerly known as Herrick's syndrome.
Blood transfusions, Iron Chelation: "Transfusion-dependent thalassemic patients and patients with sickle cell anemia maintained on transfusion for prophylactic purposes require 30 to 50 milligrams per kilogram per day of desferrioxamine infused subcutaneously by pump. One pump is required per patient. Regular assessment of body iron and assessment for complications are essential."-NCBI, stem cell transplantation.
Doctors use to use the Pneumococcal vaccination (which is commonly used to prevent a certain type of lung infection that is caused by pneumococcus bacterium) or blood transfusions to try to treat S.C.A.
Low red blood cell count, repeat infections, and periodic episodes of pain (also called crisis) that happen in your chest, abdomen and joints.
Its diagnosed by Gel electrophoresis or molecular diagnosis.
Must inherit 1 sickle cell trait from both parents.
A defective hemoglobin is the cause of sickle cell anemia. A person has an increased chance of
developing this disease
THANK YOU!
Mayo clinic.org
You tube
Medicine.net inc.
Wikipedia.org
On the top is how
normal blood flows.
On the bottom is
how sickle cell blood
flows.
sickle cell
normal cell
Here's an overview:
Normal
cell
Sickle
cell
Medicine.net
Flexible circular shape cell that
flows smoothly
through blood
vessels.
Inflexible crescent
shape cell that sticks
to the sides of the
blood vessels.
sickle cell disease.org
Information from:
Videos from:
Pictures from:
Sickle cell anemia
if they have the trait for
protection against malaria.
Is a genetic disorder affecting your
red blood cells.

-People with 1 the sickle cell trait can
not have it or develop it but can
pass it down.
Facts
-------
- June 19th is sickle cell world day
sumanasinc.com
http://www.sumanasinc.com/webcontent/animations/content/gelelectrophoresis.html
Want to learn what Gel electrophoresis
see link below.
Want to know more about
Molecular diagnosis watch
this video.
Full transcript