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Parkinson's

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by

Ryan Schultz

on 21 February 2013

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Transcript of Parkinson's

Summary of:Correction of a Rat Model of Parkinson’s Disease by Coexpression of Tyrosine Hydroxylase and Aromatic Amino Acid Decarboxylase from a Helper Virus-Free Herpes Simplex Virus Type-1 Vector Overview: Dopamine's biosynthetic pathway Caused by low Dopamine levels Various Treatment Options Types of Treatments for PD Goals: Correction of Rat Parkinson's disease Tyrosine Hydrolase (TH) expression
Rate limiting step in production of Dopamine
Aromatic L-amino acid Decarboxilase (AADC) expression
Becomes the rate limiting step when patients are administered L-Dopa Methods Plasmid Construction Vector
Packaging 6-OHDA Induced Lesions Gene Transfer Collect Results Results Expression of TH and AADC Drawbacks? Mutations Size Virulence Gene deactivation L-Dopa Stem Cells Vector Explore the behavioral and biochemical effects of Tyrosine Hydrolase and AADC plasmids in rats with PD Behavioral Correction of PD Biochemical correction of PD Sun, M., Zhang, G.-r., Kong, L., Holmes, C., Wang, X., Zhang, W., et al. (2003). Correction of a Rat Model of Parkinson’s Disease by Coexpression of Tyrosine Hydroxylase and Aromatic Amino Acid Decarboxylase from a Helper Virus-Free Herpes Simplex Virus Type-1 Vctor. Hum Gene Ther, 415–424. Bibliography Sun, M., Zhang, G.-r., Kong, L., Holmes, C., Wang, X., Zhang, W., et al. (2003). Correction of a Rat Model of Parkinson’s Disease by Coexpression of Tyrosine Hydroxylase and Aromatic Amino Acid Decarboxylase from a Helper Virus-Free Herpes Simplex Virus Type-1 Vctor. Hum Gene Ther, 415–424. Questions?
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