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Transcript of Hibernation overview
80 beats/min torpor
8 beats/min arousal
15 beats/min 240 beats/min BHB, beta-hydroxybutyrate;
MCT1, monocarboxylic acid transporter 1;
PDK4, pyruvate dehydrogenase kinase 4;
SCOT, succinyl CoA transferase;
TCA cycle, tricarboxylic acid cycle. Andrews M T et al. (2009) Model showing the mechanism of β-hydroxybutyrate utilization and glucose conservation
in the heart and brain during hibernation. reducing excitotoxicity preventing oxidative stress reducing post-ischemic inflammation Maintenance and regeneration
of synapses Resistance to ichemia and reperfusion Resistance to cardiac arrest Maintenance of bone density during torpor Thank you!