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Hibernation overview

membrane project Spring 2013

Carla Frare

on 30 April 2013

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Transcript of Hibernation overview

Torpor bout and IAB Oxygen consumption Hibernation Torpor and Interbout Arousal (IBA) Annual cycle Spring Metabolism Carbohydrate Hibernation in the Drew lab Hypothermia protect brain against ischemic injury Adaptive strategy HIBERNATION Summer Fall Winter Arctic Ground Squirrel Lipid-based metabolism Heart rate entrance
in torpor
80 beats/min torpor
8 beats/min arousal
15 beats/min 240 beats/min BHB, beta-hydroxybutyrate;
MCT1, monocarboxylic acid transporter 1;
PDK4, pyruvate dehydrogenase kinase 4;
SCOT, succinyl CoA transferase;
TCA cycle, tricarboxylic acid cycle. Andrews M T et al. (2009) Model showing the mechanism of β-hydroxybutyrate utilization and glucose conservation
in the heart and brain during hibernation. reducing excitotoxicity preventing oxidative stress reducing post-ischemic inflammation Maintenance and regeneration
of synapses Resistance to ichemia and reperfusion Resistance to cardiac arrest Maintenance of bone density during torpor Thank you!
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