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Anatomy & Physiology: The Blood

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by

james donahue

on 3 November 2016

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Transcript of Anatomy & Physiology: The Blood

Be sure you can:
Blood
~55% plasma
~45% RBCs (hematocrit)
>1% WBCs and platelets (buffy coat)
Red Blood Cells (Erythrocytes)
~97% hemoglobin
heme - iron component
transports oxygen
globin - protein component
How does the RBC transport blood gases?
Reversible binding
Erythropoiesis
Formation of RBCs
Regulated by erythropoietin (EPO)
Anemias
- low oxygen carrying capacity
- not a disease, a symptom
Insufficient RBCs
hemorrhagic
hemolytic
aplastic
Low hemoglobin
iron deficiency
pernicious
Abnormal hemoglobin
thalassemia
sickle-cell
Polycythemia
White Blood Cells
(Leukocytes)

altitude
blood doping
Granulocytes - short life
basophils - blue
eosinophils - red
neutrophils - purple
Agranulocytes -long life
lymphocytes (T and B cells)
monocytes - macrophages
Never ~ 60%
Let ~ 20%
Minions ~ 8%
Eat ~ 2%
Bananas ~ <1%
Leukemia
myelocytic
lymphoid
Platelets
(Thrombocytes)

Fragments of the megakaryocyte
maintain hemostasis
formation of prothrombin activator
prothrombin
thrombin
fibrinogen
(soluble)
fibrin
(insoluble)
Thrombus v. Embolus
Blood Groups
four main blood types
Rh factor
SO...
WHAT COLOR IS BLOOD???
How many RBCs are there?
there are about 5 million RBCs/cubic mm
1 cubic cm = 1000 cubic mm
because
1 cubic cm = 1 ml
1 ml of blood = 5 billion RBCs
and since
1000 ml = 1L
with
5 L of blood/person
there are about
5 billion RBCs/ml x 5000 ml
which equals roughly
25 trillion RBCs/person

60, 20, 8, 2, 0
Never, Let, My, Engine, Blow
Neutrophils
Lymphocytes
Eosinophils
Basophils

No Reaction
Agglutination
(clumping of cells)
You are working with the police investigating a murder. An unknown sample of blood was left at the crime scene. Upon testing, you discover that the blood reacted with Anti-A serum, but not Anti-B nor Anti-Rh. What was the blood type of the unknown sample?
Anti-A
Anti-B
Anti-Rh
an exception (but not human)
http://goo.gl/sG8tbv
https://goo.gl/qeX1RL
If there is 5-6 L of blood in the body...
Plasma
www.youtube.com/watch?v=SzsQWIMYbN8&feature=youtu.be
Massive Pulmonary Embolism
Full transcript