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Lassa Fever

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by

Regan Carley

on 3 March 2014

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Transcript of Lassa Fever

Transmission

The Lassa virus is transmitted by a certain kind of rodent called a multimammate rat or Mastomys rat
Infection is life lasting in rats
These rats live in the homes of people so it can be easily transmittable.
Transmitted through contact with rats’ urine, droppings, blood, or anything it touched
A person transmits it by coughing or touching their fluids
Treatment

Can be treated with an antiviral drug called Ribavirin
It's is helpful, but it’s not the best because of its risk of toxicity, it has to be highly administered, and it’s teratogenic (effect on embryo growth), and is expensive.
Researchers at the USAMRIID facility, where military biologists study infectious diseases, have a potential vaccine for the disease
Discovery of the Disease
Discovered by John Frame in Nigeria, Africa . He discovered it in 1969 when nurses in Africa had fallen to the illness.
Statistics
Averagely, 100,00- 500,000 people are infected a year and around 5,000 die
10 to 15 percent of people who are admitted to the hospital with a disease in Africa have the disease
95 percent of pregnant women die of this disease because of a more severe infection
Sources
"Lassa Fever." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, n.d. Web. 17 Feb. 2014.
<http://www.cdc.gov/ncidod/dvrd/spb/mnpages/dispages/lassaf.htm>.

"What Is Lassa Fever?" What Is Lassa Fever? News Medical, n.d. Web. 17 Feb. 2014.
<http://www.news-medical.net/health/What-is-Lassa-Fever.aspx>.

McCormick, J.B. "American Society for MicrobiologyJournal of Virology." Effective Vaccine for Lassa Fever. American Society for Microbiology, n.d. Web. 17 Feb. 2014.
<http://jvi.asm.org/content/74/15/6777.full>.

"Nigeria: Lassa Fever Outbreak (Situation as of 22 March, 2012)." World Health Organization. World Health Organization, n.d. Web. 17 Feb. 2014. <http://www.afro.who.int/en/clusters-a-programmes/dpc/epidemic-a-pandemic-alert-and-response/outbreak-news/3593-nigeria-lassa-fever-outbreak-situation-as-of-22-march-2012.html>.

Miller, Stephen. "John Frame, 90, Discovered Lassa Fever." - The New York Sun. The New York Sun, 22 Jan. 2008. Web. 17 Feb. 2014. <http://www.nysun.com/obituaries/john-frame-90-discovered-lassa-fever/69916/>.

Harper, Tara K. "TKH Virology Notes: Lassa Fever." Lassa Fever: Description, Vector, Mechanism, Symptoms, Mortality Rates, and so On... Tara K Harper, 2004. Web. 17 Feb. 2014. <http://tarakharper.com/v_lassa.htm#sympt>.

Baush, D.G. "American Society for MicrobiologyJournal of Clinical Microbiology." Diagnosis and Clinical Virology of Lassa Fever as Evaluated by Enzyme-Linked Immunosorbent Assay, Indirect Fluorescent-Antibody Test, and Virus Isolation. American Society for Microbiology, July 2000. Web. 17 Feb. 2014. <http://jcm.asm.org/content/38/7/2670.full>.
"Nephilim Giants • View Topic - Deadly Lassa Fever Outbreak Kills Seven in Nigeria‏." Nephilim Giants • View Topic - Deadly Lassa Fever Outbreak Kills Seven in Nigeria‏. N.p., n.d. Web. 03 Mar. 2014. <http://www.nephilimgiants.com/viewtopic.php?f=6&t=600>.
Kelley, Ronan. "Nigeria Epidemiology Reports 2013 - FluTrackers." Nigeria Epidemiology Reports 2013 - FluTrackers. N.p., 13 Dec. 2013. Web. 03 Mar. 2014. <http://www.flutrackers.com/forum/showthread.php?p=519544>.
"LASSA FEVER." LASSA FEVER. N.p., n.d. Web. 03 Mar. 2014. <http://g-influencemagazine.com/lasa-fever.html>.


Lassa Fever

Fever
Fatigue
Cough
Pain behind the sternum
Hemorrhaging in organs (i.e. stomach and intestines)
Bleeding in the Gums
Diarrhea
Abdominal Pain
People who most likely won't live develop shock, clouded mental status, pleural effusion, and grand mal seizures
Conjunctivitis (Red Eyes)
Deafness
mucosal bleeding
Prevention
avoiding contact with the rats by a cleaner home and storage of food in containers
What is Lassa Fever?
Lassa Fever is an acute viral disease caused by the Lassa virus from the Arenaviridae family
It's a single stranded RNA zoonotic virus
Is an airborne virus that displays many similar symptoms to Eboli.
Mostly found in animals
The word “Lassa” comes from a town in Nigeria, Africa, where it originated from
Incubation Period
Incubation period is around 10 days, but it can vary from 1 to 24 days
Infected people usually go seek treatment in the first 4 to 5 days, when they start displaying symptoms
By: Regan Carley
Symptoms
Epidemics
Between 1970 and 1972 many out breaks occurred in Nigeria.
28 deaths at a hospital, 13 deaths
the disease spread to Liberia, Seria, Mali, Guinea, and Gambia.
Epidemics
As of March 22nd, 2012, Lassa Fever has infected 623 people and killing 70
Has affected 19/36 states in Africa
The State and Federal Government, with the World Health Organization have taken action with better sanitation and disease surveillance.
Reproduction Process
First, the virus enters the bloodstream and then enters the lymph vessels, respiratory tract, and the digestive tract
It then multiplies in cells in the reticuloendothelial system (part of the immune system)
Outbreaks occurring of 2012
Current Outbreaks
Full transcript