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What is Polydopamine ?


on 24 May 2013

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Transcript of Polydopamine

Polydopamine Dopamine is considered a small molecule mimic of Mefp-5 in that it contains the catechol and primary amine functional groups found in the side chains of DOPA and Lys residues. Incubation of substrates in an alkaline dopamine solution resulted in oxidative polymerization of dopamine and formation of a heterogeneous polymer coating. A variety of secondary immobilization reactions using the polydopamine coating as a base or “primer” led to various functional coatings, including grafted polymer coatings, metal films, and self-assembled monolayers. Polydopamine 20091532 Kim, Houng-kyung
20124433 Baek, Jin-wook Mytilus edulis foot protein (Mefp) Mussel 1. Attachable to all type of inorganic and organic surfaces
2. Sets in wet environments
3. Non-toxic and bio-friendly classically adhesion-resistant materials such as poly(tetrafluoroethylene) (PTFE) A simple organic chemical in the catecholamine family that plays a number of important roles in the brains and bodies of animals. Dopamine amine group (NH2) dihydroxyphenethylamine dihydroxyphenylalanine (knwon as L-DOPA) Nitrogen Hydrogen Carbon Oxygen C 8 H 11 N O 2 What is special about mussel? or boiled. It is great steamed Then, how mussel stick to surfaces Clues may lie in the amino acid composition of proteins near the plaque-substrate interface ! Dopamine : bioinspird building
block for surface coatings Thin film deposition of polydopamine by dip-coating an object in an alkaline dopamine solution Thickness evolution of polydopamine coating on Si as measured by AFM of patterned surfaces. XPS characterization of 25 different polydopamine-coated surfaces. The bar graph represents the intensity of characteristic substrate signal before (hatched) and after (solid) coating by polydopamine. The intensity of the unmodified substrate signal is in each case normalized to 100%. Substrates with characteristic XPS signals indistinguishable from the polydopamine signal are marked by “N.A.” The blue circles represent the N/C after polydopamine coating N/C = 0.125 -(theoretical value) 25 diverse materials coated for 3 hours (10 nm or more thickness)
Little variation in the atomic composition of coating (blue circle)
=> composition of the polymer coating was independent of the substrate composition
N/C signal 0.1 to 0.13 is similar to theoretical value for dopamine (N/C)
=> The coating is derived from dopamine polymerization Actually the exact polymerization mechanism is unknown at this time, it is likely to involve oxidation of the catechol to a quinone, followed by polymerization in a manner reminiscent of melanin formation, which occurs through polymerization of structurally similar compounds
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