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Adjuvants and ANtigen Characteristics

Serology
by

mel ola

on 14 December 2014

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Transcript of Adjuvants and ANtigen Characteristics

Adjuvant and
Antigen Characteristics

By Group 1 BSMT 3-A
Macromolecule size
Antigens' Characteristics
Adjuvants
Chemical Composition and molecular complexity
Foreignness
Definition
Latin, adiuvare: to aid
substance administered with an immunogen that increases the Immune response
Examples
Aluminum salts
Hepatits B Vaccination
Freund's Complete Adjuvant
Adjuvants
enhance the immune response by :
prolonging the existence of immunogen in the area
increasing the effective size of the immunogen
increasing the number of macrophages
1. Macromolecule size
2. Chemical Composition and Molecular Complexity
3. Foreignness
4. The ability to be processed and presented with MHC molecules
Molecular weight:
at least10,000 daltons
over 100,000 daltons
Rule of thumb:
"The greater the MW, the more potent the molecule."
Proteins
Carbohydrates
B cells
T cells
A, B, H Blood Group Antigens
Rh, and Lewis Antigens
Note:
Pure Nucleic Acids and Lipids are not immunogenic by themselves.
Self
Nonself
Example

Plant Protein
ABILITY to be processed and presented with MHC molecules
Antigen processing
involves enzymatic digestion to create small peptides or pieces that can be complexed to MHC molecules to present to responsive lymphocytes.
Poor Immunogen
Full transcript