Loading presentation...

Present Remotely

Send the link below via email or IM

Copy

Present to your audience

Start remote presentation

  • Invited audience members will follow you as you navigate and present
  • People invited to a presentation do not need a Prezi account
  • This link expires 10 minutes after you close the presentation
  • A maximum of 30 users can follow your presentation
  • Learn more about this feature in our knowledge base article

Do you really want to delete this prezi?

Neither you, nor the coeditors you shared it with will be able to recover it again.

DeleteCancel

Make your likes visible on Facebook?

Connect your Facebook account to Prezi and let your likes appear on your timeline.
You can change this under Settings & Account at any time.

No, thanks

Coronary Stents

No description
by

Mohanned El-Natour

on 3 June 2010

Comments (0)

Please log in to add your comment.

Report abuse

Transcript of Coronary Stents

Evaluating Coronary Stents
As a Viable Treatment for
Coronary Heart Disease BME 475 - Liu
S. Cho | M. El-Natour
T. Kennedy | E. Robinson Narrowing of the small vessels supplying blood and oxygen to the heart.
Coronary heart disease (CHD) is the leading cause of death in the United States for men and women
Complications include:
Heart Attack
Heart Failure
Unstable angina
Sudden Death Problem: Coronary Heart Disease Symptoms
Symptoms vary from case to case, some asymptomatic, some are very clear.
Chest pain or discomfort (angina)
Heavy heart,
squeezing, tension in your chest neck, arms, stomach, and back
Shortness of breath and fatigue Causes and Risk Factors Artheriosclerosis
Decreased blood flow to heart
Risk Factors:
Heredity
Age
Diabetes
High BP
Metabolic Syndrome
Smoking
Chronic Kidney disease Tests and Diagnosis ECG
Exercise Stress Test
Echocardiogram
Nuclear Scan
Electron Bean Computed Tomography
CT Angiography
MRI
Coronary Angiography/Arteriography Stent Design/Requirements For succesful interventional use, a stent should be
Non-allergenic
Non-Inflammatory
Radiopaque
Well resolved in MRI
Flexible with sustainable elasticity to be plastically deformed
Resistant to vessel recoil
Thin enough to minimize obstruction to blood flow
Biocompatible to avoid vessel reocclusion
Gas Cluster Ion beam to smooth micro roughness Current solution for coronary heart disease Lifestyle changes
Quit smoking
Healthy foods
Exercise
Drugs
Cholesterol-modifying medications
Aspirin
Beta blockers
Non-invasive method
Angioplasty
Stent placement
Minimally invasive
Heart surgery
Invasive
Coronary artery bypass surgery Palmaz-Schatz stent
Poly-l-lactic acid (PLLA)
Biodegradable
No stent thrombosis was detected
Minimal neointimal coverage
PDLLA
Local inflammatory response to polylactide--polymer resorption process
Reduce restenosis development


Stent Technology Progression Despite intervention restenosis remains key issue
Introduction of pharmacological agents to stent surface
Application to bare surface
Integration with biodegradable polymer Drug Eluting Stents (DES) Using biobeneficial coating polymers to treat site without drug release
A medical device comprising a plurality of capsules, said capsules comprising a therapeutic agent and a multilayer polyelectrolyte shell, wherein said medical device is adapted to apply a pressure to said capsules that is greater than or equal to the critical pressure of at least a portion of said capsules such that therapeutic agent is released from said capsules.
Using material that are non-allergenic, non-inflammatory
Coating with radiopaque polymers
A transmyocardial implant includes a hollow rigid conduit having a first portion and a second portion. The first portion is sized to be larger than an initial lumen diameter of a coronary vessel. The first portion is smaller than an enlarged lumen diameter. The second portion is sized to extend... Stent Processing Treatments Drawbacks Coating with radiopaque polymers
A transmyocardial implant includes a hollow rigid conduit having a first portion and a second portion. The first portion is sized to be larger than an initial lumen diameter of a coronary vessel. The first portion is smaller than an enlarged lumen diameter. The second portion is sized to extend... Restenosis
Thrombosis
Drug side effects
Certain drug interactions
Size and shape issues
Negative Effects Sources http://www.google.com/patents?id=21_KAAAAEBAJ&printsec=abstract&zoom=4&source=gbs_overview_r&cad=0#v=onepage&q&f=true
http://www.google.com/patents?id=P8zKAAAAEBAJ&printsec=abstract&zoom=4&source=gbs_overview_r&cad=0#v=onepage&q&f=false
http://www.google.com/patents/about?id=4snKAAAAEBAJ&dq=coronary+stent
http://www.google.com/patents?id=A6IDAAAAEBAJ&printsec=abstract&zoom=4&source=gbs_overview_r&cad=0#v=onepage&q&f=false
http://www.google.com/patents?id=rGwHAAAAEBAJ&printsec=abstract&zoom=4&source=gbs_overview_r&cad=0#v=onepage&q&f=false
http://www.google.com/patents?id=QbQYAAAAEBAJ&printsec=abstract&zoom=4&source=gbs_overview_r&cad=0#v=onepage&q&f=false
http://www.google.com/patents?id=Mx8RAAAAEBAJ&printsec=abstract&zoom=4&source=gbs_overview_r&cad=0#v=onepage&q&f=false
http://www.google.com/patents?id=Mx8RAAAAEBAJ&printsec=abstract&zoom=4&source=gbs_overview_r&cad=0#v=onepage&q&f=false
http://www3.interscience.wiley.com/journal/72508953/abstract?CRETRY=1&SRETRY=0

http://nejm.highwire.org/cgi/content/abstract/350/3/221
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1B-4DM1VYV-2G&_user=965532&_coverDate=10%2F29%2F2004&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1357090772&_rerunOrigin=scholar.google&_acct=C000049540&_version=1&_urlVersion=0&_userid=965532&md5=6648ad04635bfd2246ce618372a64fd4
http://content.nejm.org/cgi/content/abstract/339/23/1665
http://synapse.koreamed.org/Synapse/Data/PDFData/0054KCJ/kcj-38-393.pdf
http://www.touchcardiology.com/files/article_pdfs/asgar_0.pdf
http://www.cathlabdigest.com/fileas/imagecache/normal/photos/meyer3dtif.jpg
http://www.mayoclinic.com/health/coronary-artery-disease/ds00064/dsection=treatments-and-drugs
http://www.ptca.org/des.html
conclusion - combination therapy
- long term effectiveness
- social/economic motivation
- novel adaptations

>Future studies...
Full transcript