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Proteins and Gene Expression

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Elizabeth Tomlin

on 13 August 2014

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Transcript of Proteins and Gene Expression

The function of proteins depends mainly on their 3-dimensional structure or shape
What alters protein structure and function?
The Law of Mass Action allows us to predict which way a reversible reaction will proceed
Go to Mastering A&P!
Make sure to read the relevant sections in the text

Make sure to do your homework assignments on time!
Gene expression and

The primary structure is the sequence of amino acids
The secondary structure is the first degree of folding
Enzymes catalyze reactions
Proteins include enzymes, transporters, receptors, hormones and other signals, and structural and contractile proteins
Proteins can be embedded in the plasma membrane
Proteins can act as signals
Proteins form the "scaffolding" of cells
(What determines this sequence?)
Amino acids are held together by covalent (peptide) bonds
Secondary structure is held together by hydrogen bonds
Tertiary structure is the 3rd level of folding.
The "shape" of the protein is held by mostly weaker bonds - hydrogen, ionic, van der Waals
Quaternary structure occurs when more than one protein is linked together
Hemoglobin has 4 subunits
Mutations in DNA can alter the primary structure
eg. sickle cell disease
Weaker bonds can be broken by heat, chemicals, changes in pH
from Silverthorn,D. 2013.
Human Physiology. An Integrated Approach
The effect of sickle
cell disease on hemoglobin.
Full transcript