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Transcript of COAGULATION
When you cut or injure yourself, your body stops the bleeding by forming a blood clot, the Proteins and particles in your blood, called platelets, stick together to form the blood clot .the process of forming a clot is called coagulation. Normal coagulation is important during an injury, as it helps stop a cut from bleeding and starts the healing process. Hypercoagulated state !!! Causes of hypercoagulable states include medications, female hormones, (estrogens and birth control pills), after surgery (post- operative period, especially hip, knee, and urinary system procedures), pregnancy, phospholipid antibodies in blood (anticardiolipin antibodies, lupus anticoagulant), cancer (though most patients with a hypercoagulable state do not have cancer), elevated blood homocysteine levels, and inherited protein deficiencies (antithrombin III, factor V Leiden, protein S, protein C, and others). However, the blood shouldn’t clot when it’s just moving through the body. If blood tends to clot too much, it is referred to as a hypercoagulable state or thrombophilia However, the blood shouldn’t clot when it’s just moving through the body. If blood tends to clot too much, it is referred to as a hypercoagulable state or thrombophilia A hypercoagulable state is the medical term for a condition in which there is an abnormally increased tendency toward blood clotting (coagulation).A People with hypercoagulable states have an increased risk for blood clots developing in the arteries and veins . clot inside a blood vessel is also called a thrombus or an embolus. Most cases of hemophilia arise as an inherited disorder, which means that a person is born with hemophilia as determined by his genetic makeup. The condition is caused by a defect in one of the clotting factor genes that lies on the X chromosome Hemophilia almost always occurs in males since the gene can be passed from mother to son, and a son lacks a second X chromosome to make up for the defective gene. Girls, on the other hand, are likely to be carriers of hemophilia but unlikely to actually have the disorder. Another commonly known coagulation disorder is hemophilia, a condition in which patients bleed for long periods of time before clotting Another commonly known coagulational disorder is hemophilia, a condition in which patients bleed for long periods of time before clotting. Another type of coagulational disorder is THROMBOCYTOPENIA .Thrombocytopenia may be acquired or congenital. It represents a defective or decreased production of platelets. Symptoms include sudden onset of small spots of hemorrhage on the skin, or bleeding into mucous membranes .The disorder may also be evident as blood in vomit or stools, bleeding during surgery.Some patients show none of these symptoms, but complain of fatigue and general weakness. Thrombocytopenia Diagnosis:-
Several blood tests can be used to detect various coagulational disorders , including medical history and physical examination.
In the case of acquired coagulation disorders, information such as prior or current diseases and medications will be important in determining the cause of the blood disorder In mild cases, treatment may involve the use of drugs that stimulate the release of deficient clotting factors. In severe cases, bleeding may only stop if the clotting factor that is missing is replaced through infusion of donated human blood in the form of fresh frozen plasma or cryoprecipitate. PREVENTION !!!
Prevention of coagulation disorders varies. Acquired disorders may only be prevented by preventing onset of the underlying disorders .
Hereditary disorders can be predicted with prenatal testing and genetic counseling. Prevention of severe bleeding episodes may be accomplished by refraining from activities that could cause injury, such as contact sports . And so on !! AVOID!! OVERALL REVIEW ON COAGULATION Blood clotting !! COAGULATION COAGULATION