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TISSUE ENGINEERING - ONLY FUTUREPLAN OR ALREADY AN ALTERNATIVE METHOD TO RECONSTRUCT BODY TISSUE ?

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olivia nagorski

on 5 April 2016

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Transcript of TISSUE ENGINEERING - ONLY FUTUREPLAN OR ALREADY AN ALTERNATIVE METHOD TO RECONSTRUCT BODY TISSUE ?

Technical University of Berlin , Institute of Biotechnology -

Prof. Dr. Ronald Lauster
and members of the Department of Biotechnology group


Photos of the place and the main theme photo of this presentation were taken by myself
Bibliography / SOURCES



PICTURES:

http://www.laborundmore.com/thumb/a0789f4f/Bildschirmfoto%202014-03-07%26nbsp%3Bum%26nbsp%3B08.48.54.png
https://woodyoubuyit.files.wordpress.com/2012/07/woodbackground.jpghttp://images.google.de/imgres?imgurl=https%3A%2F%2Fwww.berlin.de%2Fsen%2Fbildung%2Fschulverzeichnis_und_portraets%2Fanwendung%2Fbilder%2F05Y04.jpg&imgrefurl=https%3A%2F%2Fwww.berlin.de%2Fsen%2Fbildung%2Fschulverzeichnis_und_portraets%2Fanwendung%2FSchulportrait.aspx%3FIDSchulzweig%3D15389&h=320&w=640&tbnid=cAyhm0WyWGrNTM%3A&docid=I4blAY5u9P69FM&ei=5j0AV8XwIsKusQHbhY3QAw&tbm=isch&iact=rc&uact=3&page=1&start=0&ndsp=26&ved=0ahUKEwjF-52E9_DLAhVCVywKHdtCAzoQMwgdKAAwAA
http://image.slidesharecdn.com/tissueengineeringitsapplicationinoraland-140304232402-phpapp02/95/tissue-engineering-its-application-in-oral-and-maxillo-facial-surgery-certified-fixed-orthodontic-courses-by-indian-dental-academy-6-638.jpg?cb=1408754740
http://www.intechopen.com/source/html/41232/media/image4.jpeg
http://www.texasheart.org/Research/images/RMR_keystone_web180.jpg
http://si.wsj.net/public/resources/images/PJ-BJ704A_BIOPR_G_20120917175109.jpg
http://tissuescience-regenerativemedicine.conferenceseries.com/upload-images/tissuescience2016-16742.jpg
http://www.20min.ch/interaktiv/ersatz_mensch/haut_etc/pics/haut_artificial.jpg
http://images.fineartamerica.com/images-medium-large/1-jean-baptiste-lamarck-french-naturalist-science-source.jpg
http://images.google.de/imgres?imgurl=http%3A%2F%2Fmedfab.de%2Fwp-content%2Fuploads%2F2015%2F03%2FBioprinting-medfab-3D-Druck-520x245.jpg&imgrefurl=http%3A%2F%2Fmedfab.de%2Ftag%2Ftissue-engineering%2F&h=245&w=520&tbnid=iR5fOzD-nFZ7jM%3A&docid=NJb6-83yPfU_aM&ei=gDEBV_S5I4LRswHcsaPoAQ&tbm=isch&iact=rc&uact=3&dur=861&page=1&start=0&ndsp=28&ved=0ahUKEwj0-eCs3_LLAhWC6CwKHdzYCB0QMwgqKAcwBw
http://www.intechopen.com/source/html/45069/media/image1.png
http://images.google.de/imgres?imgurl=http%3A%2F%2Fwww.huangi.com%2Fimages%2Fr%2Fqpwqroptw_p.jpg&imgrefurl=http%3A%2F%2Fwww.huangi.com%2Farticle%2F12313651867%2F&h=332&w=318&tbnid=O-X7Mkk-MwO76M%3A&docid=cwN-SNOFuhZl2M&ei=hFcBV7DVBMbpsQHrw4yoDg&tbm=isch&iact=rc&uact=3&dur=448&page=1&start=0&ndsp=39&ved=0ahUKEwiwp4zNg_PLAhXGdCwKHeshA-UQMwgvKAkwCQ
http://images.google.de/imgres?imgurl=http%3A%2F%2Fwww.huangi.com%2Fimages%2Fr%2Fqpw
http://buechnerportal.de/files/cache/386ba3607388448921aa3eb83085689b_f50.jpg
qroptw_p.jpg&imgrefurl=http%3A%2F%2Fwww.huangi.com%2Farticle%2F12313651867%2F&h=332&w=318&tbnid=O-X7Mkk-MwO76M%3A&docid=cwN-SNOFuhZl2M&ei=hFcBV7DVBMbpsQHrw4yoDg&tbm=isch&iact=rc&uact=3&dur=448&page=1&start=0&ndsp=39&ved=0ahUKEwiwp4zNg_PLAhXGdCwKHeshA-UQMwgvKAkwCQ
http://www.vigyanprasar.gov.in/scientists/Hooke.jpghttp://www.vigyanprasar.gov.in/scientists/Hooke.jpg
https://d1o50x50snmhul.cloudfront.net/wp-content/uploads/2013/11/mg22029440.800-2_800.jpg
https://optn.transplant.hrsa.gov/media/1258/organshortage-new.png
http://bme240.eng.uci.edu/students/06s/cphuang/Img/Tissue%20engineering%20diagram.jpg
http://file1.npage.de/005957/27/bilder/virchow.jpg
http://research.uni-leipzig.de/agintern/uni600/bilder/thiersch2.jpg
https://cellbiology.med.unsw.edu.au/cellbiology/images/6/67/ZRoss_Granville_Harrison.jpg

LAST ACCESS: 01.04.2016
PRIMARY SUBJECT : BIOLOGY
SECUNDARY SUBJECT : ENGLISH
OUTLINE OF MY PRESENTATION
Olivia Nagorski
T
issue ngineering
E
HISTORICAL BACKGROUND
PRESENT
PAST
Robert Hooke
1665
twenty first century
general methods of TE nowadays


1.) Re- and Decellularization
2.) Genetic modification of animal organs
3.) Organs from the 3D-Printer
Schleiden and Schwann
1.) Defying TISSUE ENGINEERING

7.) Discussing the topic of leading question
+

3.) Introducing the method
4.) Clarifying the neccesity of the procedure
5.) PROS and CONS

6.) Goals to achieve and a quick look in the future
Concluding : Tissue Engineering - Only a future plan or already a method to reconstruct body tissue ?
2.) Step to the past and future :
The historical background



abstract tissue replacement a common need in clinical medicine solution when there is too less tissue available
prolonging or saving thousands of lives every year
usage of own cells to avoid any repulsive reactions
individual implants
destruction of embryos not required - usage of adult stem cells or EST's from therapeutic cloning instead
still expanding field


even autologeously build tissues can be rejected by the host
remaining chance of hidden illnesses or diseases that were present in the base tissue
ethical considerations: usage of embryonic stem cells is only restricted in Germany, Ireland and France
no capillary network yet to provide the scaffolds with nutrition



vital tissue gets abstracted, cleaned from a patient and cut in tiny pieces in the operating room

with the help of protease's from its cell assembly, the cells get detached of their tissue

the vital tissue gets isolated from the other components through a filter

the cells expand through a specially adjusted culture medium

expanded cell culture gets seeded onto a
scaffold
that provides a biochemical environment

until the cells get to produce their own extracellular matrix, the biochemical environment drives down information of the required tissue to them

the tissues grow on a scaffold which will completely resorb as the new tissue grows

the new tissue get implanted
and has to be able to survive, restore normal function and integrate with the surrounding tissues
Tissue Engineers from
all over the world
1874
Clinical relevance


Dermatology
:
skin in the areas of neck, nose and ears


Plastic Surgery
:
cartilage for the creation of the external ear


Degenerative diseases
:
Heart diseases, Diabetes, Alzheimers


Traumatic injuries
:
burns, loss of limb, bone repair






one of the youngest fields of medicine

a part of the regenerative medicine

in vitro fertilization of human tissue

Integration of knowledge,methods and perceptions from
medicine,bio-and engineering
sciences
developing biological substitutes to

DEFINITION
CONCLUSION
1805
1838-1839
1858
1907
1897
1980


DISCOVERY OF THE CELL
UNDERSTANDING :
LIVE BEEING BASED
ON INDIVIDUAL CELLS
CELL THEORY - CELL AS A UNIT
UNDERSTANDING :
CELLS ARISE FROM
PRE-EXISTING CELLS
GROWING CELLS OUTSIDE
THE BODY FOR THE
VERY FIRST TIME
ATTEMPT: GROWING SKIN CELLS
INTO GRANULATING WOUNDS
IN VITRO GROWN
CELLS IN A FROG
DEVELOPEMENT AND
CLINICAL USE OF
SKIN REPLACEMENTS
1981
1990
1993
FIRST SKIN REPLACEMENT EVER
SUBSTITUTE TISSUES FOR SKIN :
GROWN OUTSIDE THE BODY
IMPLANTING TUMOR CELLS INTO A PIG
Lorenz Oken
Robert Virchow
Leo Loeb
Ross G. Harrison
Hermann Thiersch
Neccesity
not enough required tissue or substitudes in clinic everyday life
ALTERNATIVE TO SKIN GRAFTING
©

TU BERLIN
METHOD
FUTURE PLANS
SIGNIFICANT
MARKET POTENTIAL



manufacturing of a functioning human heart not possible yet due the complex structure not integrating into the surrounding tissues and having any potential for regeneration or growth yet beyond reach for even the most sophisticated machines


understanding of physical properties of native tissues they aim to replace
understanding effects of stimulations of Physics and Chemics in cell function,cell growth and other differentiations
ultimating the use of medical therapies
improvement in general
bringing the method to middle class society
FUTURE PLANS

functions of the tissue
RECOVER
PRESERVE
IMPROVE



FUTURE PLAN REMAINING FOR :
hearts ,livers and kidneys




- still in research
- very different stages of developement all around
the world due competitive
yet possible: heart valves or small parts of organs are printed for almost 20 years now (Charité Berlin)
achievements of the last years
might have a major influence and impact on
future health care practice

wide range of commercially available products
C:\Users\Olivia\Desktop\txchnologist tumblr.gif 2.gif
file:///C:/Users/Olivia/Desktop/txchnologist%20tumblr.gif
Kidney like organoids
from Australia and Netherlands
EXAMPLE
NOT USEFULL FOR IMPLANTATION BUT
FOR
DRUG AND PHARMA SCREENING
Tissue Engineered kidneys
react just like normal do
TEMPORARY
NEW USE FOR TISSUE ENGINEERING
no need for
animal testing
in far future
TISSUE ENGINEERING
-
A SOON COMING ALTERNATIVE FOR
FULL RECONSTRUCTION OF BODY TISSUE
ONLY A FUTURE PLAN
OR ALREADY A METHOD TO RECONSTRUCT BODY TISSUE
?

PRIMARY SUBJECT : BIOLOGY
SECUNDARY SUBJECT : ENGLISCH
BOOKS:

http://www.amazon.de/Zukunftstechnologie-Tissue-Engineering-Zellbiologie-nstlichen-ebook/dp/B0096QYPFA
http://eu.wiley.com/WileyCDA/WileyTitle/productCd-3527659803.html
http://www.amazon.de/Zukunftstechnologie-Tissue-Engineering-Zellbiologie-k%C3%BCnstlichen/dp/3527307931

LAST ACCESS: 29.02.2016


INFORMATION:

http://bioegrad.berkeley.edu/faculty/tissue
http://www.wiley-vch.de/publish/dt/books/bySubjectLS00/ISBN3-527-30793-1/?sID=l0jchu4drejvoejork0rhlt084
https://www.uni-hannover.de/fileadmin/luh/content/alumni/unimagazin/2010/32-34__boeer_internet.pdf
http://www.uni-leipzig.de/~pharm/phatech/content/Forschung/
http://www.chirurgie2.ukw.de/forschung/experimentelle-forschung/tissue-engineering.html
https://books.google.de/books?id=ret-E8tMWxEC&pg=PT194&lpg=PT194&dq=tissue+engineering+forschung+zukunftstechnologie&source=bl&ots=D
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http://rheumatologie.charite.de/forschung/forschungslabore/ag_sittinger/
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https://www.uniklinik-freiburg.de/plastischechirurgie/forschung.html
http://www.klinikum.uni-muenchen.de/Herzchirurgische-Klinik-und-Poliklinik/de/Forschung/Arbeitsgruppe-Tissue-Engineering/Tissue-Engineering/index.html
http://www.springermedizin.de/kardiovaskulaeres-tissue-engineering/5968544.html
https://www.klinikum.uni-heidelberg.de/Tissue-Engineering.107665.0.html
http://flexikon.doccheck.com/de/Tissue_Engineering
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http://www.nature.com/nbt/journal/v18/n10s/full/nbt1000_IT56.html

LAST ACCESS: 28.03.2016
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