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Endocrine System Overview

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by

David Lapetino

on 19 December 2014

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Transcript of Endocrine System Overview

Endocrine
System

Conclusion
Receptors are the lock...
Hormones are the key...
Both local and global...
- Facilitates communication
Responds to environment (both internal and external)
Development
Growth
Danger/stress
Metabolism
Fight infection
Reproduction...
Basically, everything!
2 types...
Coordinates far-flung
elements
Helps regulate everything!
Functions via glands
Exocrine
Endocrine
Deposits into body cavities, surface of skin
Think "Ducts"
Think "bloodstream"
How?
Intracellular communication
Responding
to signals
Environmental
or
Cellular
Via
Hormones!
(and glands)
More on Glands...
Manufacture secretions (2 types)...
Exocrine
Endocrine
Deposited into body cavities
(through ducts)
Sent directly into bloodstream
10 glands
Hormones released throughout...
Why don't all cells respond?
Receptors!
Special surface molecule
(Often protein)
Target cell
(has sensitive receptor)
Ligand
When bound...
Changes in cellular activity occur
Receptors can be on surface or internal...
Proteins bind to surface... (can't pass through membrane... hydrophilic, but lipophobic)
Lipids pass through membrane (lipophilic, but hydrophobic)
Autocrine vs. Paracrine
Interacts w/ cell that created it
(Cell controls its own activity)
Secretion travels short distance
to target cells
Coordinates cells within an organ
Phermone?
Leave body, signal cells of other organisms
Feedback
Acts as "on/off" switch
Negative Feedback
Hormone prevents its own production... works in opposite direction of the disturbance
Example: Thermostat
Positive Feedback
Hormone promotes the disturbance occurring to the body...
Example: Childbirth, lactation
Hormone binds to
membrane receptor
Activated receptor sets off
cascade
that activates an enzyme
Enzyme catalyzes reactions, creating
second-messenger molecules
(cAMP)
Causes changes that
promote cellular response
Full transcript