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Caffeine

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by

Janet Lam

on 3 November 2014

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Transcript of Caffeine

What is Caffeine?
"most popular drug"
90% of the world consumes caffeine everyday
coffee
tea
chocolate
energy drinks
soft drinks
pills (ie. headache/weight loss pills)
Dosage
30 mg - noticeable stimulant effects
500 mg increases heart rate and breathing
more than 10 g-
lethal dose
Caffeine is a
diuretic

causes an increase in urine production
Mechanism of Action
Without Adenosine
Withdrawal
upset stomach
anxiety
headaches
fatigue
irritability
restlessness
sleeplessness
frequent urination
muscle pains

Adenosine
Agonist
Neurotransmitter
limits signals sent to release NE


Caffeine
adenosine receptor antagonist
exogeneous drug
increases signals to release NE
Kidneys
With Adenosine
With Adenosine&Caffeine
Overdose Potential
fatal overdose is
rare

Caffeine Poisoning:
panic attacks
tremors
nausea
vomiting
irregular or rapid heart rate
confusion
seizures
Addiction Potential
Caffeine
Hanan Ahmed
Janet Lam

Coffee
Works Cited
Discussion Questions
NE:
adrenaline
fight or flight mechanism:
faster breathing
faster heart rate
increased alertness
dilated pupils
muscles tighten
energy
decrease in appetite
dehydrates you?
causes sustain weight loss?
safe during pregnancy?
causes insomnia?
increase in
tolerance:
builds up depending on caffeine intake and how consistent the dosage is
Metabolism
speeds up metabolism
enzymes work harder
half-life of 5-7 hours
after 8-10 hours, caffeine is 75% metabolized

False!
False!
http://www.fda.gov/food/recallsoutbreaksemergencies/safetyalertsadvisories/ucm405787.htm
http://well.blogs.nytimes.com/2014/03/24/caffeinated-a-history-of-our-favorite-stimulant/
http://www.businessinsider.com/how-does-coffee-affect-your-brain-2014-8
http://www.sciencemuseum.org.uk/whoami/findoutmore/yourbrain/howdodrugsaffectyourbrain/whatarestimulants/howdoescaffeineaffectyou.aspx


http://time.com/64985/how-caffeine-affects-brain/
http://www.yourperformance.co.uk/caffeine-performance.html
http://www.webmd.com/migraines-headaches/guide/triggers-caffeine
http://www.webmd.com/balance/caffeine-myths-and-facts
http://abcnews.go.com/GMA/coffee-myths-busted-caffeine/story?id=5552790
http://visual.ly/caffeine-poster-how-much-caffeine-are-you-drinking
http://thebrain.mcgill.ca/flash/i/i_03/i_03_m/i_03_m_par/i_03_m_par_cafeine.html#drogues
Route of Administration: Oral
non polar

easily gets absorbed into cell membranes of stomach and intestines

effects within 30-60 minutes

Neurotransmitter Effects
caffeine in combination with other drugs is dangerous: blood pressure (ie. antidepressants)
stimulant that causes dependency
up regulation of adenosine receptors
down regulation of NE receptors
* Avoid intense withdrawal by decreasing intake and limiting dosage NOT by stopping abruptly
1) Have you ever worked out with caffeine? How did you feel?
2) Do you agree with Michaels in that caffeine pills are safer because the dose is more regulated? Why or why not ?
3) If caffeine is allowed on the “Biggest Loser” why do you think caffeine pills aren’t?
4) Should caffeine pills replace energy drinks when exercising?
Full transcript