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Free to try, no credit card requiredDPIM mutations' background
the lab's mutational strategy
data from literature
alpha fold predictions
What is Y2H?
Yeast two-hybrid screening system is a molecular biology technique used to discover and analyze protein-protein interactions and protein-DNA interactions by testing for physical interactions (ex.: binding) between two proteins or between a protein and a DNA molecule, respectively.
The mutations (Pol32 permutations for Y2H assays X Pol1) we are interested in are as following:
Pol32:AlphaFold predictions:
predicted aligned error plot
DPIM area:
DED GY:
confidence level of the residues according to AlphaFold:
D -> A CONFIDENT
E -> A CONFIDENT
D -> A VERY HIGH
G -> A CONFIDENT
Y -> A CONFIDENT
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