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DPIM mutations' background

the lab's mutational strategy

data from literature

alpha fold predictions

What is Y2H?

Yeast two-hybrid screening system is a molecular biology technique used to discover and analyze protein-protein interactions and protein-DNA interactions by testing for physical interactions (ex.: binding) between two proteins or between a protein and a DNA molecule, respectively.

The mutations (Pol32 permutations for Y2H assays X Pol1) we are interested in are as following:

Pol32:AlphaFold predictions:

predicted aligned error plot

DPIM area:

DED GY:

confidence level of the residues according to AlphaFold:

D -> A CONFIDENT

E -> A CONFIDENT

D -> A VERY HIGH

G -> A CONFIDENT

Y -> A CONFIDENT

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